BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

191 related articles for article (PubMed ID: 30914376)

  • 1. Evaluation of a TGN1412 analogue using in vitro assays and two immune humanized mouse models.
    Yan H; Bhagwat B; Sanden D; Willingham A; Tan A; Knapton AD; Weaver JL; Howard KE
    Toxicol Appl Pharmacol; 2019 Jun; 372():57-69. PubMed ID: 30914376
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bone marrow-liver-thymus (BLT) immune humanized mice as a model to predict cytokine release syndrome.
    Yan H; Semple KM; Gonzaléz CM; Howard KE
    Transl Res; 2019 Aug; 210():43-56. PubMed ID: 31082370
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28.
    Poirier N; Mary C; Le Bas-Bernardet S; Daguin V; Belarif L; Chevalier M; Hervouet J; Minault D; Ville S; Charpy V; Blancho G; Vanhove B
    MAbs; 2014; 6(3):697-707. PubMed ID: 24598534
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human Fcγ receptors compete for TGN1412 binding that determines the antibody's effector function.
    Dudek S; Weißmüller S; Anzaghe M; Miller L; Sterr S; Hoffmann K; Hengel H; Waibler Z
    Eur J Immunol; 2019 Jul; 49(7):1117-1126. PubMed ID: 31002172
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells.
    Eastwood D; Findlay L; Poole S; Bird C; Wadhwa M; Moore M; Burns C; Thorpe R; Stebbings R
    Br J Pharmacol; 2010 Oct; 161(3):512-26. PubMed ID: 20880392
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412.
    Römer PS; Berr S; Avota E; Na SY; Battaglia M; ten Berge I; Einsele H; Hünig T
    Blood; 2011 Dec; 118(26):6772-82. PubMed ID: 21931118
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
    Ye C; Yang H; Cheng M; Shultz LD; Greiner DL; Brehm MA; Keck JG
    FASEB J; 2020 Sep; 34(9):12963-12975. PubMed ID: 32772418
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm.
    Panoskaltsis N; McCarthy NE; Stagg AJ; Mummery CJ; Husni M; Arebi N; Greenstein D; Price CL; Al-Hassi HO; Koutinas M; Mantalaris A; Knight SC
    Cancer Immunol Immunother; 2021 Apr; 70(4):1127-1142. PubMed ID: 33033851
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies.
    Dhir V; Fort M; Mahmood A; Higbee R; Warren W; Narayanan P; Wittman V
    J Immunotoxicol; 2012; 9(1):34-42. PubMed ID: 22074378
    [TBL] [Abstract][Full Text] [Related]  

  • 10. TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model.
    Weißmüller S; Kronhart S; Kreuz D; Schnierle B; Kalinke U; Kirberg J; Hanschmann KM; Waibler Z
    PLoS One; 2016; 11(3):e0149093. PubMed ID: 26959227
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Systemic human T cell developmental processes in humanized mice cotransplanted with human fetal thymus/liver tissue and hematopoietic stem cells.
    Joo SY; Chung YS; Choi B; Kim M; Kim JH; Jun TG; Chang J; Sprent J; Surh CD; Joh JW; Kim SJ
    Transplantation; 2012 Dec; 94(11):1095-102. PubMed ID: 23222735
    [TBL] [Abstract][Full Text] [Related]  

  • 12. After TGN1412: recent developments in cytokine release assays.
    Stebbings R; Eastwood D; Poole S; Thorpe R
    J Immunotoxicol; 2013; 10(1):75-82. PubMed ID: 22967038
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A whole blood in vitro cytokine release assay with aqueous monoclonal antibody presentation for the prediction of therapeutic protein induced cytokine release syndrome in humans.
    Wolf B; Morgan H; Krieg J; Gani Z; Milicov A; Warncke M; Brennan F; Jones S; Sims J; Kiessling A
    Cytokine; 2012 Dec; 60(3):828-37. PubMed ID: 22986013
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals?
    Iwata Y; Harada A; Hara T; Kubo C; Inoue T; Tabo M; Ploix C; Manigold T; Hinton H; Mishima M
    J Toxicol Sci; 2016; 41(4):523-31. PubMed ID: 27432238
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Co-transplantation of human fetal thymus, bone and CD34(+) cells into young adult immunodeficient NOD/SCID IL2Rγ(null) mice optimizes humanized mice that mount adaptive antibody responses.
    Chung YS; Son JK; Choi B; Joo SY; Lee YS; Park JB; Moon H; Kim TJ; Kim SH; Hong S; Chang J; Kang MS; Kim SJ
    Clin Immunol; 2015 Apr; 157(2):156-65. PubMed ID: 25725428
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy?
    Sandilands GP; Wilson M; Huser C; Jolly L; Sands WA; McSharry C
    Clin Exp Immunol; 2010 Dec; 162(3):516-27. PubMed ID: 20964641
    [TBL] [Abstract][Full Text] [Related]  

  • 17. BLT-Immune Humanized Mice as a Model for Nivolumab-Induced Immune-Mediated Adverse Events: Comparison of the NOG and NOG-EXL Strains.
    Weaver JL; Zadrozny LM; Gabrielson K; Semple KM; Shea KI; Howard KE
    Toxicol Sci; 2019 May; 169(1):194-208. PubMed ID: 30850839
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A simple whole blood bioassay detects cytokine responses to anti-CD28SA and anti-CD52 antibodies.
    Bailey L; Moreno L; Manigold T; Krasniqi S; Kropshofer H; Hinton H; Singer T; Suter L; Hansel TT; Mitchell JA
    J Pharmacol Toxicol Methods; 2013; 68(2):231-239. PubMed ID: 23280407
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Generation of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties.
    Elsayed A; Pellegrino C; Plüss L; Peissert F; Benz R; Ulrich F; Thorhallsdottir G; Plaza SD; Villa A; Mock J; Puca E; De Luca R; Manz MG; Halin C; Neri D
    MAbs; 2023; 15(1):2220839. PubMed ID: 37288872
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Using the BLT humanized mouse as a stem cell based gene therapy tumor model.
    Vatakis DN; Bristol GC; Kim SG; Levin B; Liu W; Radu CG; Kitchen SG; Zack JA
    J Vis Exp; 2012 Dec; (70):e4181. PubMed ID: 23271478
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.