BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

113 related articles for article (PubMed ID: 30928196)

  • 1. Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors.
    Jaikhan P; Buranrat B; Itoh Y; Chotitumnavee J; Kurohara T; Suzuki T
    Bioorg Med Chem Lett; 2019 May; 29(10):1173-1176. PubMed ID: 30928196
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy.
    Miyake Y; Itoh Y; Hatanaka A; Suzuma Y; Suzuki M; Kodama H; Arai Y; Suzuki T
    Bioorg Med Chem; 2019 Mar; 27(6):1119-1129. PubMed ID: 30745098
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
    Horton JR; Liu X; Gale M; Wu L; Shanks JR; Zhang X; Webber PJ; Bell JSK; Kales SC; Mott BT; Rai G; Jansen DJ; Henderson MJ; Urban DJ; Hall MD; Simeonov A; Maloney DJ; Johns MA; Fu H; Jadhav A; Vertino PM; Yan Q; Cheng X
    Cell Chem Biol; 2016 Jul; 23(7):769-781. PubMed ID: 27427228
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
    Horton JR; Woodcock CB; Chen Q; Liu X; Zhang X; Shanks J; Rai G; Mott BT; Jansen DJ; Kales SC; Henderson MJ; Cyr M; Pohida K; Hu X; Shah P; Xu X; Jadhav A; Maloney DJ; Hall MD; Simeonov A; Fu H; Vertino PM; Cheng X
    J Med Chem; 2018 Dec; 61(23):10588-10601. PubMed ID: 30392349
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-based design and discovery of potent and selective KDM5 inhibitors.
    Nie Z; Shi L; Lai C; O'Connell SM; Xu J; Stansfield RK; Hosfield DJ; Veal JM; Stafford JA
    Bioorg Med Chem Lett; 2018 May; 28(9):1490-1494. PubMed ID: 29627262
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The KDM5 family of histone demethylases as targets in oncology drug discovery.
    Rasmussen PB; Staller P
    Epigenomics; 2014 Jun; 6(3):277-86. PubMed ID: 25111482
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.
    Gale M; Sayegh J; Cao J; Norcia M; Gareiss P; Hoyer D; Merkel JS; Yan Q
    Oncotarget; 2016 Jun; 7(26):39931-39944. PubMed ID: 27224921
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of potent, selective KDM5 inhibitors.
    Gehling VS; Bellon SF; Harmange JC; LeBlanc Y; Poy F; Odate S; Buker S; Lan F; Arora S; Williamson KE; Sandy P; Cummings RT; Bailey CM; Bergeron L; Mao W; Gustafson A; Liu Y; VanderPorten E; Audia JE; Trojer P; Albrecht BK
    Bioorg Med Chem Lett; 2016 Sep; 26(17):4350-4. PubMed ID: 27476424
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The emerging role of KDM5A in human cancer.
    Yang GJ; Zhu MH; Lu XJ; Liu YJ; Lu JF; Leung CH; Ma DL; Chen J
    J Hematol Oncol; 2021 Feb; 14(1):30. PubMed ID: 33596982
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.
    Vinogradova M; Gehling VS; Gustafson A; Arora S; Tindell CA; Wilson C; Williamson KE; Guler GD; Gangurde P; Manieri W; Busby J; Flynn EM; Lan F; Kim HJ; Odate S; Cochran AG; Liu Y; Wongchenko M; Yang Y; Cheung TK; Maile TM; Lau T; Costa M; Hegde GV; Jackson E; Pitti R; Arnott D; Bailey C; Bellon S; Cummings RT; Albrecht BK; Harmange JC; Kiefer JR; Trojer P; Classon M
    Nat Chem Biol; 2016 Jul; 12(7):531-8. PubMed ID: 27214401
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacological inhibition of KDM5A for cancer treatment.
    Yang GJ; Wu J; Miao L; Zhu MH; Zhou QJ; Lu XJ; Lu JF; Leung CH; Ma DL; Chen J
    Eur J Med Chem; 2021 Dec; 226():113855. PubMed ID: 34555614
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase.
    Zhou X; Sun H; Chen H; Zavadil J; Kluz T; Arita A; Costa M
    Cancer Res; 2010 May; 70(10):4214-21. PubMed ID: 20406991
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling.
    Longbotham JE; Chio CM; Dharmarajan V; Trnka MJ; Torres IO; Goswami D; Ruiz K; Burlingame AL; Griffin PR; Fujimori DG
    Nat Commun; 2019 Jan; 10(1):94. PubMed ID: 30626866
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy.
    Yang GJ; Wang W; Mok SWF; Wu C; Law BYK; Miao XM; Wu KJ; Zhong HJ; Wong CY; Wong VKW; Ma DL; Leung CH
    Angew Chem Int Ed Engl; 2018 Oct; 57(40):13091-13095. PubMed ID: 29968419
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.
    Petronikolou N; Longbotham JE; Fujimori DG
    Biochemistry; 2020 Feb; 59(5):647-651. PubMed ID: 31985200
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of in vitro JMJD lysine demethylase candidate substrates via systematic determination of substrate preference.
    Hoekstra M; Biggar KK
    Anal Biochem; 2021 Nov; 633():114429. PubMed ID: 34678252
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
    Tumber A; Nuzzi A; Hookway ES; Hatch SB; Velupillai S; Johansson C; Kawamura A; Savitsky P; Yapp C; Szykowska A; Wu N; Bountra C; Strain-Damerell C; Burgess-Brown NA; Ruda GF; Fedorov O; Munro S; England KS; Nowak RP; Schofield CJ; La Thangue NB; Pawlyn C; Davies F; Morgan G; Athanasou N; Müller S; Oppermann U; Brennan PE
    Cell Chem Biol; 2017 Mar; 24(3):371-380. PubMed ID: 28262558
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hypoxia induces rapid changes to histone methylation and reprograms chromatin.
    Batie M; Frost J; Frost M; Wilson JW; Schofield P; Rocha S
    Science; 2019 Mar; 363(6432):1222-1226. PubMed ID: 30872526
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.
    Labadie SS; Dragovich PS; Cummings RT; Deshmukh G; Gustafson A; Han N; Harmange JC; Kiefer JR; Li Y; Liang J; Liederer BM; Liu Y; Manieri W; Mao W; Murray L; Ortwine DF; Trojer P; VanderPorten E; Vinogradova M; Wen L
    Bioorg Med Chem Lett; 2016 Sep; 26(18):4492-4496. PubMed ID: 27499454
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells.
    Banelli B; Daga A; Forlani A; Allemanni G; Marubbi D; Pistillo MP; Profumo A; Romani M
    Oncotarget; 2017 May; 8(21):34896-34910. PubMed ID: 28432280
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.