BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

182 related articles for article (PubMed ID: 30930162)

  • 1. Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.
    Hajian B; Scocchera E; Shoen C; Krucinska J; Viswanathan K; G-Dayanandan N; Erlandsen H; Estrada A; Mikušová K; Korduláková J; Cynamon M; Wright D
    Cell Chem Biol; 2019 Jun; 26(6):781-791.e6. PubMed ID: 30930162
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Dual-Targeting Activity of the Metabolite Substrate of Para-amino Salicyclic Acid in the Mycobacterial Folate Pathway: Atomistic and Structural Perspectives.
    Agoni C; Ramharack P; Salifu EY; Soliman MES
    Protein J; 2020 Apr; 39(2):106-117. PubMed ID: 32086691
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
    Cheng YS; Sacchettini JC
    Biochemistry; 2016 Feb; 55(7):1107-19. PubMed ID: 26848874
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Methionine Antagonizes
    Howe MD; Kordus SL; Cole MS; Bauman AA; Aldrich CC; Baughn AD; Minato Y
    Front Cell Infect Microbiol; 2018; 8():399. PubMed ID: 30483484
    [No Abstract]   [Full Text] [Related]  

  • 5. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.
    Zheng J; Rubin EJ; Bifani P; Mathys V; Lim V; Au M; Jang J; Nam J; Dick T; Walker JR; Pethe K; Camacho LR
    J Biol Chem; 2013 Aug; 288(32):23447-56. PubMed ID: 23779105
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.
    Nixon MR; Saionz KW; Koo MS; Szymonifka MJ; Jung H; Roberts JP; Nandakumar M; Kumar A; Liao R; Rustad T; Sacchettini JC; Rhee KY; Freundlich JS; Sherman DR
    Chem Biol; 2014 Jul; 21(7):819-30. PubMed ID: 24954008
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.
    Chakraborty S; Gruber T; Barry CE; Boshoff HI; Rhee KY
    Science; 2013 Jan; 339(6115):88-91. PubMed ID: 23118010
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.
    Minato Y; Thiede JM; Kordus SL; McKlveen EJ; Turman BJ; Baughn AD
    Antimicrob Agents Chemother; 2015 Sep; 59(9):5097-106. PubMed ID: 26033719
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Deletion of
    Yang SS; Hu YB; Wang XD; Gao YR; Li K; Zhang XE; Chen SY; Zhang TY; Gu J; Deng JY
    Antimicrob Agents Chemother; 2017 Oct; 61(10):. PubMed ID: 28717039
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates.
    Thiede JM; Kordus SL; Turman BJ; Buonomo JA; Aldrich CC; Minato Y; Baughn AD
    Sci Rep; 2016 Dec; 6():38083. PubMed ID: 27905500
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors.
    Shelke RU; Degani MS; Raju A; Ray MK; Rajan MG
    Arch Pharm (Weinheim); 2016 Aug; 349(8):602-13. PubMed ID: 27320965
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potency boost of a
    Aragaw WW; Lee BM; Yang X; Zimmerman MD; Gengenbacher M; Dartois V; Chui WK; Jackson CJ; Dick T
    Proc Natl Acad Sci U S A; 2021 Jun; 118(25):. PubMed ID: 34161270
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis.
    Urban M; Šlachtová V; Brulíková L
    Eur J Med Chem; 2021 Feb; 212():113139. PubMed ID: 33422979
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of novel selective Mtb-DHFR inhibitors as antitubercular agents through structure-based computational techniques.
    Sharma K; Neshat N; Sharma S; Giri N; Srivastava A; Almalki F; Saifullah K; Alam MM; Shaquiquzzaman M; Akhter M
    Arch Pharm (Weinheim); 2020 Feb; 353(2):e1900287. PubMed ID: 31867798
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Folate Pathway Inhibitors, An Underestimated and Underexplored Molecular Target for New Anti-tuberculosis Agents.
    Vassiliades SV; Borges LG; Giarolla J; Parise-Filho R
    Mini Rev Med Chem; 2023; 23(17):1711-1732. PubMed ID: 36744693
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria.
    Rengarajan J; Sassetti CM; Naroditskaya V; Sloutsky A; Bloom BR; Rubin EJ
    Mol Microbiol; 2004 Jul; 53(1):275-82. PubMed ID: 15225321
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparum.
    Wang P; Nirmalan N; Wang Q; Sims PF; Hyde JE
    Mol Biochem Parasitol; 2004 May; 135(1):77-87. PubMed ID: 15287589
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents.
    Sharma K; Tanwar O; Deora GS; Ali S; Alam MM; Zaman MS; Krishna VS; Sriram D; Akhter M
    Bioorg Med Chem; 2019 Apr; 27(7):1421-1429. PubMed ID: 30827867
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacological validation of dihydrofolate reductase as a drug target in
    Aragaw WW; Negatu DA; Bungard CJ; Dartois VA; Marrouni AE; Nickbarg EB; Olsen DB; Warrass R; Dick T
    Antimicrob Agents Chemother; 2024 Jan; 68(1):e0071723. PubMed ID: 38018963
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Editorial: Current status and perspective on drug targets in tubercle bacilli and drug design of antituberculous agents based on structure-activity relationship.
    Tomioka H
    Curr Pharm Des; 2014; 20(27):4305-6. PubMed ID: 24245755
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.