142 related articles for article (PubMed ID: 30931859)
1. Potentiation of PBD Dimers by Lipophilicity Manipulation.
Cailleau T; Adams LR; Arora N; Kang GD; Masterson L; Patel N; Hartley JA; Mao S; Harper J; Howard PW
Curr Top Med Chem; 2019; 19(9):741-752. PubMed ID: 30931859
[TBL] [Abstract][Full Text] [Related]
2. Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads.
Donnell AF; Zhang Y; Stang EM; Wei DD; Tebben AJ; Perez HL; Schroeder GM; Pan C; Rao C; Borzilleri RM; Vite GD; Gangwar S
Bioorg Med Chem Lett; 2017 Dec; 27(23):5267-5271. PubMed ID: 29102228
[TBL] [Abstract][Full Text] [Related]
3. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.
Hartley JA; Flynn MJ; Bingham JP; Corbett S; Reinert H; Tiberghien A; Masterson LA; Antonow D; Adams L; Chowdhury S; Williams DG; Mao S; Harper J; Havenith CEG; Zammarchi F; Chivers S; van Berkel PH; Howard PW
Sci Rep; 2018 Jul; 8(1):10479. PubMed ID: 29992976
[TBL] [Abstract][Full Text] [Related]
4. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers.
Gregson SJ; Barrett AM; Patel NV; Kang GD; Schiavone D; Sult E; Barry CS; Vijayakrishnan B; Adams LR; Masterson LA; D'Hooge F; Snaith M; Harper J; Hartley JA; Howard PW
Eur J Med Chem; 2019 Oct; 179():591-607. PubMed ID: 31279293
[TBL] [Abstract][Full Text] [Related]
6. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
Gregson SJ; Masterson LA; Wei B; Pillow TH; Spencer SD; Kang GD; Yu SF; Raab H; Lau J; Li G; Lewis Phillips GD; Gunzner-Toste J; Safina BS; Ohri R; Darwish M; Kozak KR; Dela Cruz-Chuh J; Polson A; Flygare JA; Howard PW
J Med Chem; 2017 Dec; 60(23):9490-9507. PubMed ID: 29112410
[TBL] [Abstract][Full Text] [Related]
7. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
Mantaj J; Jackson PJ; Rahman KM; Thurston DE
Angew Chem Int Ed Engl; 2017 Jan; 56(2):462-488. PubMed ID: 27862776
[TBL] [Abstract][Full Text] [Related]
8. Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity.
Kamal A; Shankaraiah N; Devaiah V; Laxma Reddy K; Juvekar A; Sen S; Kurian N; Zingde S
Bioorg Med Chem Lett; 2008 Feb; 18(4):1468-73. PubMed ID: 18207392
[TBL] [Abstract][Full Text] [Related]
9. ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.
Flynn MJ; Zammarchi F; Tyrer PC; Akarca AU; Janghra N; Britten CE; Havenith CE; Levy JN; Tiberghien A; Masterson LA; Barry C; D'Hooge F; Marafioti T; Parren PW; Williams DG; Howard PW; van Berkel PH; Hartley JA
Mol Cancer Ther; 2016 Nov; 15(11):2709-2721. PubMed ID: 27535974
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
Wells G; Martin CR; Howard PW; Sands ZA; Laughton CA; Tiberghien A; Woo CK; Masterson LA; Stephenson MJ; Hartley JA; Jenkins TC; Shnyder SD; Loadman PM; Waring MJ; Thurston DE
J Med Chem; 2006 Sep; 49(18):5442-61. PubMed ID: 16942018
[TBL] [Abstract][Full Text] [Related]
11. Recent developments in novel pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis and biological evaluation.
Kumar R; Lown JW
Mini Rev Med Chem; 2003 Jun; 3(4):323-39. PubMed ID: 12678826
[TBL] [Abstract][Full Text] [Related]
12. Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters.
Kaliszczak M; Antonow D; Patel KI; Howard P; Jodrell DI; Thurston DE; Guichard SM
AAPS J; 2010 Dec; 12(4):617-27. PubMed ID: 20703960
[TBL] [Abstract][Full Text] [Related]
13. Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
Kamal A; Ramulu P; Srinivas O; Ramesh G; Kumar PP
Bioorg Med Chem Lett; 2004 Sep; 14(18):4791-4. PubMed ID: 15324909
[TBL] [Abstract][Full Text] [Related]
14. Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents.
Kamal A; Vijaya Bharathi E; Janaki Ramaiah M; Dastagiri D; Surendranadha Reddy J; Viswanath A; Sultana F; Pushpavalli SN; Pal-Bhadra M; Srivastava HK; Narahari Sastry G; Juvekar A; Sen S; Zingde S
Bioorg Med Chem; 2010 Jan; 18(2):526-42. PubMed ID: 20031423
[TBL] [Abstract][Full Text] [Related]
15. Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) dimers for cancer therapy.
Hartley JA
Expert Opin Biol Ther; 2021 Jul; 21(7):931-943. PubMed ID: 32543981
[TBL] [Abstract][Full Text] [Related]
16. Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
White JB; Fleming R; Masterson L; Ruddle BT; Zhong H; Fazenbaker C; Strout P; Rosenthal K; Reed M; Muniz-Medina V; Howard P; Dixit R; Wu H; Hinrichs MJ; Gao C; Dimasi N
MAbs; 2019 Apr; 11(3):500-515. PubMed ID: 30835621
[TBL] [Abstract][Full Text] [Related]
17. The use of molecular dynamics simulations to evaluate the DNA sequence-selectivity of G-A cross-linking PBD-duocarmycin dimers.
Jackson PJM; Rahman KM; Thurston DE
Bioorg Med Chem Lett; 2017 Jan; 27(1):102-108. PubMed ID: 27889454
[TBL] [Abstract][Full Text] [Related]
18. Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates.
Staben LR; Chen J; Cruz-Chuh JD; Del Rosario G; Go MA; Guo J; Khojasteh SC; Kozak KR; Li G; Ng C; Lewis Phillips GD; Pillow TH; Rowntree RK; Wai J; Wei B; Xu K; Xu Z; Yu SF; Zhang D; Dragovich PS
J Med Chem; 2020 Sep; 63(17):9603-9622. PubMed ID: 32787101
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity.
Kamal A; Ramesh G; Laxman N; Ramulu P; Srinivas O; Neelima K; Kondapi AK; Sreenu VB; Nagarajaram HA
J Med Chem; 2002 Oct; 45(21):4679-88. PubMed ID: 12361394
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.
Berry JM; Howard PW; Kelland LR; Thurston DE
Bioorg Med Chem Lett; 2002 May; 12(10):1413-6. PubMed ID: 11992788
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
