BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

346 related articles for article (PubMed ID: 30940908)

  • 1. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
    Christian S; Merz C; Evans L; Gradl S; Seidel H; Friberg A; Eheim A; Lejeune P; Brzezinka K; Zimmermann K; Ferrara S; Meyer H; Lesche R; Stoeckigt D; Bauser M; Haegebarth A; Sykes DB; Scadden DT; Losman JA; Janzer A
    Leukemia; 2019 Oct; 33(10):2403-2415. PubMed ID: 30940908
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
    Sykes DB; Kfoury YS; Mercier FE; Wawer MJ; Law JM; Haynes MK; Lewis TA; Schajnovitz A; Jain E; Lee D; Meyer H; Pierce KA; Tolliday NJ; Waller A; Ferrara SJ; Eheim AL; Stoeckigt D; Maxcy KL; Cobert JM; Bachand J; Szekely BA; Mukherjee S; Sklar LA; Kotz JD; Clish CB; Sadreyev RI; Clemons PA; Janzer A; Schreiber SL; Scadden DT
    Cell; 2016 Sep; 167(1):171-186.e15. PubMed ID: 27641501
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.
    Wu D; Wang W; Chen W; Lian F; Lang L; Huang Y; Xu Y; Zhang N; Chen Y; Liu M; Nussinov R; Cheng F; Lu W; Huang J
    Haematologica; 2018 Sep; 103(9):1472-1483. PubMed ID: 29880605
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia.
    Sykes DB
    Expert Opin Ther Targets; 2018 Nov; 22(11):893-898. PubMed ID: 30318938
    [No Abstract]   [Full Text] [Related]  

  • 5. Inhibition of mitochondrial complex III induces differentiation in acute myeloid leukemia.
    Zhang Y; Luo T; Ding X; Chang Y; Liu C; Zhang Y; Hao S; Yin Q; Jiang B
    Biochem Biophys Res Commun; 2021 Apr; 547():162-168. PubMed ID: 33610916
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
    Yang T; Shi X; Li S; Zhao Z; Wang J; Yu P; Li H; Wang R; Chen Z
    Biomed Pharmacother; 2023 Oct; 166():115314. PubMed ID: 37579695
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Knockdown of SALL4 Protein Enhances All-trans Retinoic Acid-induced Cellular Differentiation in Acute Myeloid Leukemia Cells.
    Liu L; Liu L; Leung LH; Cooney AJ; Chen C; Rosengart TK; Ma Y; Yang J
    J Biol Chem; 2015 Apr; 290(17):10599-609. PubMed ID: 25737450
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia.
    So J; Lewis AC; Smith LK; Stanley K; Franich R; Yoannidis D; Pijpers L; Dominguez P; Hogg SJ; Vervoort SJ; Brown FC; Johnstone RW; McDonald G; Ulanet DB; Murtie J; Gruber E; Kats LM
    EMBO Mol Med; 2022 Jul; 14(7):e15203. PubMed ID: 35514210
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
    Schenk T; Chen WC; Göllner S; Howell L; Jin L; Hebestreit K; Klein HU; Popescu AC; Burnett A; Mills K; Casero RA; Marton L; Woster P; Minden MD; Dugas M; Wang JC; Dick JE; Müller-Tidow C; Petrie K; Zelent A
    Nat Med; 2012 Mar; 18(4):605-11. PubMed ID: 22406747
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity.
    Hu S; Ueda M; Stetson L; Ignatz-Hoover J; Moreton S; Chakrabarti A; Xia Z; Karan G; de Lima M; Agrawal MK; Wald DN
    Mol Cancer Ther; 2016 Jul; 15(7):1485-1494. PubMed ID: 27196775
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts.
    Dembitz V; Lalic H; Kodvanj I; Tomic B; Batinic J; Dubravcic K; Batinic D; Bedalov A; Visnjic D
    BMC Cancer; 2020 Nov; 20(1):1090. PubMed ID: 33176741
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
    DeRatt LG; Christine Pietsch E; Tanner A; Shaffer P; Jacoby E; Wang W; Kazmi F; Zhang X; Attar RM; Edwards JP; Kuduk SD
    Bioorg Med Chem Lett; 2020 Nov; 30(22):127589. PubMed ID: 33007394
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia.
    Zhou J; Yiying Quah J; Ng Y; Chooi JY; Hui-Min Toh S; Lin B; Zea Tan T; Hosoi H; Osato M; Seet Q; Ooi LAG; Lindmark B; McHale M; Chng WJ
    Haematologica; 2020 Sep; 105(9):2286-2297. PubMed ID: 33054053
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells.
    Wang R; Xia L; Gabrilove J; Waxman S; Jing Y
    Clin Cancer Res; 2016 Mar; 22(5):1211-21. PubMed ID: 26459180
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting the SUMO Pathway Primes All-
    Baik H; Boulanger M; Hosseini M; Kowalczyk J; Zaghdoudi S; Salem T; Sarry JE; Hicheri Y; Cartron G; Piechaczyk M; Bossis G
    Cancer Res; 2018 May; 78(10):2601-2613. PubMed ID: 29487199
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CDK2 suppression synergizes with all-trans-retinoic acid to overcome the myeloid differentiation blockade of AML cells.
    Shao X; Xiang S; Fu H; Chen Y; Xu A; Liu Y; Qi X; Cao J; Zhu H; Yang B; He Q; Ying M
    Pharmacol Res; 2020 Jan; 151():104545. PubMed ID: 31740384
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia.
    Cai X; Shen YL; Zhu Q; Jia PM; Yu Y; Zhou L; Huang Y; Zhang JW; Xiong SM; Chen SJ; Wang ZY; Chen Z; Chen GQ
    Leukemia; 2000 Feb; 14(2):262-70. PubMed ID: 10673743
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A Combined Chemical, Computational, and In Vitro Approach Identifies SBL-105 as Novel DHODH Inhibitor in Acute Myeloid Leukemia Cells.
    Kamli H; Zaman GS; Shaikh A; Mobarki AA; Rajagopalan P
    Oncol Res; 2022 Jan; 28(9):899-911. PubMed ID: 34353411
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia.
    Niitsu N; Higashihara M; Honma Y
    Exp Hematol; 2002 Nov; 30(11):1273-82. PubMed ID: 12423680
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation.
    Orfali N; O'Donovan TR; Nyhan MJ; Britschgi A; Tschan MP; Cahill MR; Mongan NP; Gudas LJ; McKenna SL
    Exp Hematol; 2015 Sep; 43(9):781-93.e2. PubMed ID: 25986473
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.