BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

242 related articles for article (PubMed ID: 30964290)

  • 1. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated.
    Géraldy M; Morgen M; Sehr P; Steimbach RR; Moi D; Ridinger J; Oehme I; Witt O; Malz M; Nogueira MS; Koch O; Gunkel N; Miller AK
    J Med Chem; 2019 May; 62(9):4426-4443. PubMed ID: 30964290
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis and evaluation of novel N-hydroxybenzamides/N-hydroxypropenamides incorporating quinazolin-4(3H)-ones as histone deacetylase inhibitors and antitumor agents.
    Hieu DT; Anh DT; Tuan NM; Hai PT; Huong LT; Kim J; Kang JS; Vu TK; Dung PTP; Han SB; Nam NH; Hoa ND
    Bioorg Chem; 2018 Feb; 76():258-267. PubMed ID: 29223029
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.
    Zeyen P; Zeyn Y; Herp D; Mahmoudi F; Yesiloglu TZ; Erdmann F; Schmidt M; Robaa D; Romier C; Ridinger J; Herbst-Gervasoni CJ; Christianson DW; Oehme I; Jung M; Krämer OH; Sippl W
    Eur J Med Chem; 2022 Apr; 234():114272. PubMed ID: 35306288
    [TBL] [Abstract][Full Text] [Related]  

  • 4. PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia.
    Gawel JM; Shouksmith AE; Raouf YS; Nawar N; Toutah K; Bukhari S; Manaswiyoungkul P; Olaoye OO; Israelian J; Radu TB; Cabral AD; Sina D; Sedighi A; de Araujo ED; Gunning PT
    Eur J Med Chem; 2020 Sep; 201():112411. PubMed ID: 32615502
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.
    Morgen M; Steimbach RR; Géraldy M; Hellweg L; Sehr P; Ridinger J; Witt O; Oehme I; Herbst-Gervasoni CJ; Osko JD; Porter NJ; Christianson DW; Gunkel N; Miller AK
    ChemMedChem; 2020 Jul; 15(13):1163-1174. PubMed ID: 32348628
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of the first histone deacetylase 6/8 dual inhibitors.
    Olson DE; Wagner FF; Kaya T; Gale JP; Aidoud N; Davoine EL; Lazzaro F; Weïwer M; Zhang YL; Holson EB
    J Med Chem; 2013 Jun; 56(11):4816-20. PubMed ID: 23672185
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases.
    Christianson DW
    Acc Chem Res; 2024 Apr; 57(8):1135-1148. PubMed ID: 38530703
    [TBL] [Abstract][Full Text] [Related]  

  • 8. [New synthesis of highly selective inhibitor of histone deacetylase 6--N-hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3b]indol-5-ylmethyl)benzamide--Tubastatin A].
    Kozlov MV; Kleĭmenova AA; Konduktorov KA; Kochetkov SN
    Bioorg Khim; 2013; 39(1):117-20. PubMed ID: 23844513
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A Computational Approach to Investigate the HDAC6 and HDAC10 Binding Propensity of Psidium guajava-derived Compounds as Potential Anticancer Agents.
    Adewole KE; Ishola AA
    Curr Drug Discov Technol; 2021; 18(3):423-436. PubMed ID: 32357815
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors.
    Ibrahim Uba A; Yelekçi K
    J Biomol Struct Dyn; 2019 Sep; 37(14):3627-3636. PubMed ID: 30204052
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase.
    Herbst-Gervasoni CJ; Steimbach RR; Morgen M; Miller AK; Christianson DW
    ACS Chem Biol; 2020 Aug; 15(8):2154-2163. PubMed ID: 32659072
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6.
    Osko JD; Porter NJ; Narayana Reddy PA; Xiao YC; Rokka J; Jung M; Hooker JM; Salvino JM; Christianson DW
    J Med Chem; 2020 Jan; 63(1):295-308. PubMed ID: 31793776
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.
    Wagner FF; Olson DE; Gale JP; Kaya T; Weïwer M; Aidoud N; Thomas M; Davoine EL; Lemercier BC; Zhang YL; Holson EB
    J Med Chem; 2013 Feb; 56(4):1772-6. PubMed ID: 23368884
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A.
    De Vreese R; Verhaeghe T; Desmet T; D'hooghe M
    Chem Commun (Camb); 2013 May; 49(36):3775-7. PubMed ID: 23538448
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.
    Choi SE; Pflum MK
    Bioorg Med Chem Lett; 2012 Dec; 22(23):7084-6. PubMed ID: 23089527
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.
    Negmeldin AT; Knoff JR; Pflum MKH
    Eur J Med Chem; 2018 Jan; 143():1790-1806. PubMed ID: 29150330
    [TBL] [Abstract][Full Text] [Related]  

  • 17. HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates.
    Mak JYW; Wu KC; Gupta PK; Barbero S; McLaughlin MG; Lucke AJ; Tng J; Lim J; Loh Z; Sweet MJ; Reid RC; Liu L; Fairlie DP
    J Med Chem; 2021 Feb; 64(4):2186-2204. PubMed ID: 33570940
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
    Steimbach RR; Herbst-Gervasoni CJ; Lechner S; Stewart TM; Klinke G; Ridinger J; Géraldy MNE; Tihanyi G; Foley JR; Uhrig U; Kuster B; Poschet G; Casero RA; Médard G; Oehme I; Christianson DW; Gunkel N; Miller AK
    J Am Chem Soc; 2022 Oct; 144(41):18861-18875. PubMed ID: 36200994
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.
    Kolbinger FR; Koeneke E; Ridinger J; Heimburg T; Müller M; Bayer T; Sippl W; Jung M; Gunkel N; Miller AK; Westermann F; Witt O; Oehme I
    Arch Toxicol; 2018 Aug; 92(8):2649-2664. PubMed ID: 29947893
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages.
    Cao F; Zwinderman MRH; van Merkerk R; Ettema PE; Quax WJ; Dekker FJ
    Eur J Med Chem; 2019 Sep; 177():457-466. PubMed ID: 31181405
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.