212 related articles for article (PubMed ID: 30971495)
1. Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Morgan GJ; Yan NL; Mortenson DE; Rennella E; Blundon JM; Gwin RM; Lin CY; Stanfield RL; Brown SJ; Rosen H; Spicer TP; Fernandez-Vega V; Merlini G; Kay LE; Wilson IA; Kelly JW
Proc Natl Acad Sci U S A; 2019 Apr; 116(17):8360-8369. PubMed ID: 30971495
[TBL] [Abstract][Full Text] [Related]
2. The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains.
Morgan GJ; Kelly JW
J Mol Biol; 2016 Oct; 428(21):4280-4297. PubMed ID: 27569045
[TBL] [Abstract][Full Text] [Related]
3. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.
Yan NL; Santos-Martins D; Rennella E; Sanchez BB; Chen JS; Kay LE; Wilson IA; Morgan GJ; Forli S; Kelly JW
Bioorg Med Chem Lett; 2020 Aug; 30(16):127356. PubMed ID: 32631553
[TBL] [Abstract][Full Text] [Related]
4. Heat-induced native dimerization prevents amyloid formation by variable domain from immunoglobulin light-chain REI.
Nawata M; Tsutsumi H; Kobayashi Y; Unzai S; Mine S; Nakamura T; Uegaki K; Kamikubo H; Kataoka M; Hamada D
FEBS J; 2017 Sep; 284(18):3114-3127. PubMed ID: 28736891
[TBL] [Abstract][Full Text] [Related]
5. Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
Yan NL; Santos-Martins D; Nair R; Chu A; Wilson IA; Johnson KA; Forli S; Morgan GJ; Petrassi HM; Kelly JW
J Med Chem; 2021 May; 64(9):6273-6299. PubMed ID: 33939422
[TBL] [Abstract][Full Text] [Related]
6. Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Oberti L; Rognoni P; Barbiroli A; Lavatelli F; Russo R; Maritan M; Palladini G; Bolognesi M; Merlini G; Ricagno S
Sci Rep; 2017 Dec; 7(1):16809. PubMed ID: 29196671
[TBL] [Abstract][Full Text] [Related]
7. Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients?
Morgan GJ; Usher GA; Kelly JW
Biochemistry; 2017 Dec; 56(50):6597-6614. PubMed ID: 29200282
[TBL] [Abstract][Full Text] [Related]
8. Immunoglobulin light chain amyloid aggregation.
Blancas-Mejia LM; Misra P; Dick CJ; Cooper SA; Redhage KR; Bergman MR; Jordan TL; Maar K; Ramirez-Alvarado M
Chem Commun (Camb); 2018 Sep; 54(76):10664-10674. PubMed ID: 30087961
[TBL] [Abstract][Full Text] [Related]
9. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site.
Yan NL; Nair R; Chu A; Wilson IA; Johnson KA; Morgan GJ; Kelly JW
Bioorg Med Chem Lett; 2022 Mar; 60():128571. PubMed ID: 35065233
[TBL] [Abstract][Full Text] [Related]
10. Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis.
Yan NL; Morgan GJ; Petrassi HM; Wilson IA; Kelly JW
Curr Opin Chem Biol; 2023 Aug; 75():102319. PubMed ID: 37279624
[TBL] [Abstract][Full Text] [Related]
11. Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity.
Martin EB; Williams A; Wooliver C; Heidel RE; Adams S; Dunlap J; Ramirez-Alvarado M; Blancas-Mejia LM; Lands RH; Kennel SJ; Wall JS
PLoS One; 2017; 12(3):e0174152. PubMed ID: 28350808
[TBL] [Abstract][Full Text] [Related]
12. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain.
Cooley CB; Ryno LM; Plate L; Morgan GJ; Hulleman JD; Kelly JW; Wiseman RL
Proc Natl Acad Sci U S A; 2014 Sep; 111(36):13046-51. PubMed ID: 25157167
[TBL] [Abstract][Full Text] [Related]
13. Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains.
Maritan M; Romeo M; Oberti L; Sormanni P; Tasaki M; Russo R; Ambrosetti A; Motta P; Rognoni P; Mazzini G; Barbiroli A; Palladini G; Vendruscolo M; Diomede L; Bolognesi M; Merlini G; Lavatelli F; Ricagno S
J Mol Biol; 2020 Feb; 432(4):845-860. PubMed ID: 31874151
[TBL] [Abstract][Full Text] [Related]
14. Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis.
Poshusta TL; Sikkink LA; Leung N; Clark RJ; Dispenzieri A; Ramirez-Alvarado M
PLoS One; 2009; 4(4):e5169. PubMed ID: 19365555
[TBL] [Abstract][Full Text] [Related]
15. Decreased amyloidogenicity caused by mutational modulation of surface properties of the immunoglobulin light chain BRE variable domain.
Kobayashi Y; Tsutsumi H; Abe T; Ikeda K; Tashiro Y; Unzai S; Kamikubo H; Kataoka M; Hiroaki H; Hamada D
Biochemistry; 2014 Aug; 53(31):5162-73. PubMed ID: 25062800
[TBL] [Abstract][Full Text] [Related]
16. Role of domain interactions in the aggregation of full-length immunoglobulin light chains.
Rennella E; Morgan GJ; Kelly JW; Kay LE
Proc Natl Acad Sci U S A; 2019 Jan; 116(3):854-863. PubMed ID: 30598439
[TBL] [Abstract][Full Text] [Related]
17. The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain.
Klimtchuk ES; Gursky O; Patel RS; Laporte KL; Connors LH; Skinner M; Seldin DC
Biochemistry; 2010 Nov; 49(45):9848-57. PubMed ID: 20936823
[TBL] [Abstract][Full Text] [Related]
18. Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation.
Mazzini G; Ricagno S; Caminito S; Rognoni P; Milani P; Nuvolone M; Basset M; Foli A; Russo R; Merlini G; Palladini G; Lavatelli F
FEBS J; 2022 Jan; 289(2):494-506. PubMed ID: 34482629
[TBL] [Abstract][Full Text] [Related]
19. A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis.
Rottenaicher GJ; Absmeier RM; Meier L; Zacharias M; Buchner J
Commun Biol; 2023 Feb; 6(1):209. PubMed ID: 36823438
[TBL] [Abstract][Full Text] [Related]
20. Truncation of the constant domain drives amyloid formation by immunoglobulin light chains.
Lavatelli F; Natalello A; Marchese L; Ami D; Corazza A; Raimondi S; Mimmi MC; Malinverni S; Mangione PP; Palmer MT; Lampis A; Concardi M; Verona G; Canetti D; Arbustini E; Bellotti V; Giorgetti S
J Biol Chem; 2024 Apr; 300(4):107174. PubMed ID: 38499153
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]