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10. PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability. Tejwani V; Carroll T; Macartney T; Bandau S; Alabert C; Saredi G; Toth R; Rouse J Sci Rep; 2024 Sep; 14(1):20824. PubMed ID: 39242638 [TBL] [Abstract][Full Text] [Related]
11. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability. Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487 [TBL] [Abstract][Full Text] [Related]
12. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy. Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ; Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064 [TBL] [Abstract][Full Text] [Related]
13. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability. Kategaya L; Perumal SK; Hager JH; Belmont LD iScience; 2019 Mar; 13():488-497. PubMed ID: 30898619 [TBL] [Abstract][Full Text] [Related]
14. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR. Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A Genes Dev; 2023 Oct; 37(19-20):913-928. PubMed ID: 37932011 [TBL] [Abstract][Full Text] [Related]
15. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751 [TBL] [Abstract][Full Text] [Related]
16. WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency. Sobol RW Proc Natl Acad Sci U S A; 2023 Jan; 120(2):e2219963120. PubMed ID: 36598947 [No Abstract] [Full Text] [Related]
17. Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Newman JA; Gavard AE; Lieb S; Ravichandran MC; Hauer K; Werni P; Geist L; Böttcher J; Engen JR; Rumpel K; Samwer M; Petronczki M; Gileadi O Life Sci Alliance; 2021 Jan; 4(1):. PubMed ID: 33199508 [TBL] [Abstract][Full Text] [Related]
18. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Behan FM; Iorio F; Picco G; Gonçalves E; Beaver CM; Migliardi G; Santos R; Rao Y; Sassi F; Pinnelli M; Ansari R; Harper S; Jackson DA; McRae R; Pooley R; Wilkinson P; van der Meer D; Dow D; Buser-Doepner C; Bertotti A; Trusolino L; Stronach EA; Saez-Rodriguez J; Yusa K; Garnett MJ Nature; 2019 Apr; 568(7753):511-516. PubMed ID: 30971826 [TBL] [Abstract][Full Text] [Related]
19. WRN Helicase: Is There More to MSI-H than Immunotherapy? Wainberg ZA Cancer Discov; 2024 Aug; 14(8):1369-1371. PubMed ID: 39091203 [TBL] [Abstract][Full Text] [Related]
20. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay. Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]