These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

213 related articles for article (PubMed ID: 30974126)

  • 1. Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication.
    Chen S; Ding S; Yin Y; Xu L; Li P; Peppelenbosch MP; Pan Q; Wang W
    Antiviral Res; 2019 Jul; 167():35-44. PubMed ID: 30974126
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibiting pyrimidine biosynthesis impairs Peste des Petits Ruminants Virus replication through depletion of nucleoside pools and activation of cellular immunity.
    Jin L; Li Y; Pu F; Wang H; Zhang D; Bai J; Shang Y; Ma Z; Ma XX
    Vet Microbiol; 2021 Sep; 260():109186. PubMed ID: 34333402
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of canine distemper virus replication by blocking pyrimidine nucleotide synthesis with A77 1726, the active metabolite of the anti-inflammatory drug leflunomide.
    Li Y; Yi L; Cheng S; Wang Y; Wang J; Sun J; Zhang Q; Xu X
    J Gen Virol; 2021 Mar; 102(3):. PubMed ID: 33416466
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of dengue virus through suppression of host pyrimidine biosynthesis.
    Wang QY; Bushell S; Qing M; Xu HY; Bonavia A; Nunes S; Zhou J; Poh MK; Florez de Sessions P; Niyomrattanakit P; Dong H; Hoffmaster K; Goh A; Nilar S; Schul W; Jones S; Kramer L; Compton T; Shi PY
    J Virol; 2011 Jul; 85(13):6548-56. PubMed ID: 21507975
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture.
    Schnellrath LC; Damaso CR
    Int J Antimicrob Agents; 2011 Nov; 38(5):435-41. PubMed ID: 21840180
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses.
    Luthra P; Naidoo J; Pietzsch CA; De S; Khadka S; Anantpadma M; Williams CG; Edwards MR; Davey RA; Bukreyev A; Ready JM; Basler CF
    Antiviral Res; 2018 Oct; 158():288-302. PubMed ID: 30144461
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors "leflunomide" and "teriflunomide" in Covid-19: A narrative review.
    Kaur H; Sarma P; Bhattacharyya A; Sharma S; Chhimpa N; Prajapat M; Prakash A; Kumar S; Singh A; Singh R; Avti P; Thota P; Medhi B
    Eur J Pharmacol; 2021 Sep; 906():174233. PubMed ID: 34111397
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells.
    Lafita-Navarro MC; Venkateswaran N; Kilgore JA; Kanji S; Han J; Barnes S; Williams NS; Buszczak M; Burma S; Conacci-Sorrell M
    PLoS Genet; 2020 Nov; 16(11):e1009117. PubMed ID: 33201894
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors.
    Vyas VK; Ghate M
    Mini Rev Med Chem; 2011 Oct; 11(12):1039-55. PubMed ID: 21861807
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis.
    Yang CF; Gopula B; Liang JJ; Li JK; Chen SY; Lee YL; Chen CS; Lin YL
    Emerg Microbes Infect; 2018 Nov; 7(1):187. PubMed ID: 30459406
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
    Hurt DE; Sutton AE; Clardy J
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1610-5. PubMed ID: 16406782
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer.
    Madak JT; Bankhead A; Cuthbertson CR; Showalter HD; Neamati N
    Pharmacol Ther; 2019 Mar; 195():111-131. PubMed ID: 30347213
    [TBL] [Abstract][Full Text] [Related]  

  • 13. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation.
    Mullen NJ; Shukla SK; Thakur R; Kollala SS; Wang D; Chaika N; Santana JF; Miklavcic WR; LaBreck DA; Mallareddy JR; Price DH; Natarajan A; Mehla K; Sykes DB; Hollingsworth MA; Singh PK
    Elife; 2024 Jul; 12():. PubMed ID: 38973593
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
    Boschi D; Pippione AC; Sainas S; Lolli ML
    Eur J Med Chem; 2019 Dec; 183():111681. PubMed ID: 31557612
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis.
    Hoffmann HH; Kunz A; Simon VA; Palese P; Shaw ML
    Proc Natl Acad Sci U S A; 2011 Apr; 108(14):5777-82. PubMed ID: 21436031
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro.
    Kim YJ; Cubitt B; Cai Y; Kuhn JH; Vitt D; Kohlhof H; de la Torre JC
    Viruses; 2020 Jul; 12(8):. PubMed ID: 32751087
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
    Zeng T; Zuo Z; Luo Y; Zhao Y; Yu Y; Chen Q
    FEBS Open Bio; 2019 Aug; 9(8):1348-1354. PubMed ID: 31087527
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis.
    Marschall M; Niemann I; Kosulin K; Bootz A; Wagner S; Dobner T; Herz T; Kramer B; Leban J; Vitt D; Stamminger T; Hutterer C; Strobl S
    Antiviral Res; 2013 Dec; 100(3):640-8. PubMed ID: 24149002
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antiviral effects of selected IMPDH and DHODH inhibitors against foot and mouth disease virus.
    Mei-Jiao G; Shi-Fang L; Yan-Yan C; Jun-Jun S; Yue-Feng S; Ting-Ting R; Yong-Guang Z; Hui-Yun C
    Biomed Pharmacother; 2019 Oct; 118():109305. PubMed ID: 31545264
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo.
    Zameitat E; Freymark G; Dietz CD; Löffler M; Bölker M
    Appl Environ Microbiol; 2007 May; 73(10):3371-9. PubMed ID: 17369345
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.