BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

383 related articles for article (PubMed ID: 30981631)

  • 1. C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function.
    White MR; Mitrea DM; Zhang P; Stanley CB; Cassidy DE; Nourse A; Phillips AH; Tolbert M; Taylor JP; Kriwacki RW
    Mol Cell; 2019 May; 74(4):713-728.e6. PubMed ID: 30981631
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.
    Andrade NS; Ramic M; Esanov R; Liu W; Rybin MJ; Gaidosh G; Abdallah A; Del'Olio S; Huff TC; Chee NT; Anatha S; Gendron TF; Wahlestedt C; Zhang Y; Benatar M; Mueller C; Zeier Z
    Mol Neurodegener; 2020 Feb; 15(1):13. PubMed ID: 32093728
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
    Saberi S; Stauffer JE; Jiang J; Garcia SD; Taylor AE; Schulte D; Ohkubo T; Schloffman CL; Maldonado M; Baughn M; Rodriguez MJ; Pizzo D; Cleveland D; Ravits J
    Acta Neuropathol; 2018 Mar; 135(3):459-474. PubMed ID: 29196813
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins.
    Darling AL; Breydo L; Rivas EG; Gebru NT; Zheng D; Baker JD; Blair LJ; Dickey CA; Koren J; Uversky VN
    Int J Biol Macromol; 2019 Apr; 127():136-145. PubMed ID: 30639592
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine.
    Chen C; Yamanaka Y; Ueda K; Li P; Miyagi T; Harada Y; Tezuka S; Narumi S; Sugimoto M; Kuroda M; Hayamizu Y; Kanekura K
    J Cell Biol; 2021 Nov; 220(11):. PubMed ID: 34499080
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
    Farg MA; Konopka A; Soo KY; Ito D; Atkin JD
    Hum Mol Genet; 2017 Aug; 26(15):2882-2896. PubMed ID: 28481984
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phase Separation of Toxic Dipeptide Repeat Proteins Related to C9orf72 ALS/FTD.
    Jafarinia H; van der Giessen E; Onck PR
    Biophys J; 2020 Aug; 119(4):843-851. PubMed ID: 32730793
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTD.
    Odeh HM; Shorter J
    Emerg Top Life Sci; 2020 Dec; 4(3):293-305. PubMed ID: 32639008
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity.
    Bennett CL; Dastidar S; Arnold FJ; McKinstry SU; Stockford C; Freibaum BD; Sopher BL; Wu M; Seidner G; Joiner W; Taylor JP; West RJH; La Spada AR
    Acta Neuropathol Commun; 2023 Oct; 11(1):164. PubMed ID: 37845749
    [TBL] [Abstract][Full Text] [Related]  

  • 10. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
    Lee KH; Zhang P; Kim HJ; Mitrea DM; Sarkar M; Freibaum BD; Cika J; Coughlin M; Messing J; Molliex A; Maxwell BA; Kim NC; Temirov J; Moore J; Kolaitis RM; Shaw TI; Bai B; Peng J; Kriwacki RW; Taylor JP
    Cell; 2016 Oct; 167(3):774-788.e17. PubMed ID: 27768896
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity.
    Quaegebeur A; Glaria I; Lashley T; Isaacs AM
    Acta Neuropathol Commun; 2020 Nov; 8(1):184. PubMed ID: 33168090
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis.
    Suzuki H; Shibagaki Y; Hattori S; Matsuoka M
    Cell Death Dis; 2018 Sep; 9(10):975. PubMed ID: 30250194
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA.
    Suzuki H; Matsuoka M
    J Neurochem; 2021 Aug; 158(3):753-765. PubMed ID: 34081786
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats.
    Corman A; Jung B; Häggblad M; Bräutigam L; Lafarga V; Lidemalm L; Hühn D; Carreras-Puigvert J; Fernandez-Capetillo O
    Cell Chem Biol; 2019 Feb; 26(2):235-243.e5. PubMed ID: 30527999
    [TBL] [Abstract][Full Text] [Related]  

  • 15. C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in
    Xu W; Xu J
    J Neurosci; 2018 Aug; 38(35):7741-7752. PubMed ID: 30037833
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients.
    Yin S; Lopez-Gonzalez R; Kunz RC; Gangopadhyay J; Borufka C; Gygi SP; Gao FB; Reed R
    Cell Rep; 2017 Jun; 19(11):2244-2256. PubMed ID: 28614712
    [TBL] [Abstract][Full Text] [Related]  

  • 17. C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.
    Lee YB; Baskaran P; Gomez-Deza J; Chen HJ; Nishimura AL; Smith BN; Troakes C; Adachi Y; Stepto A; Petrucelli L; Gallo JM; Hirth F; Rogelj B; Guthrie S; Shaw CE
    Hum Mol Genet; 2017 Dec; 26(24):4765-4777. PubMed ID: 28973350
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration.
    Mizielinska S; Ridler CE; Balendra R; Thoeng A; Woodling NS; Grässer FA; Plagnol V; Lashley T; Partridge L; Isaacs AM
    Acta Neuropathol Commun; 2017 Apr; 5(1):29. PubMed ID: 28420437
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pathogenesis underlying hexanucleotide repeat expansions in
    Chong ZZ; Menkes DL; Souayah N
    Rev Neurosci; 2024 Jan; 35(1):85-97. PubMed ID: 37525497
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Poly-GP in cerebrospinal fluid links
    Lehmer C; Oeckl P; Weishaupt JH; Volk AE; Diehl-Schmid J; Schroeter ML; Lauer M; Kornhuber J; Levin J; Fassbender K; Landwehrmeyer B; ; Schludi MH; Arzberger T; Kremmer E; Flatley A; Feederle R; Steinacker P; Weydt P; Ludolph AC; Edbauer D; Otto M
    EMBO Mol Med; 2017 Jul; 9(7):859-868. PubMed ID: 28408402
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.