BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

211 related articles for article (PubMed ID: 30991803)

  • 1. Hybrid QM/MM vs Pure MM Molecular Dynamics for Evaluating Water Distribution within p21
    Tichauer RH; Favre G; Cabantous S; Brut M
    J Phys Chem B; 2019 May; 123(18):3935-3944. PubMed ID: 30991803
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Water Distribution within Wild-Type NRas Protein and Q61 Mutants during Unrestrained QM/MM Dynamics.
    Tichauer RH; Favre G; Cabantous S; Landa G; Hemeryck A; Brut M
    Biophys J; 2018 Oct; 115(8):1417-1430. PubMed ID: 30224050
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics.
    Mello LV; van Aalten DM; Findlay JB
    Protein Eng; 1997 Apr; 10(4):381-7. PubMed ID: 9194162
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanisms of guanosine triphosphate hydrolysis by Ras and Ras-GAP proteins as rationalized by ab initio QM/MM simulations.
    Grigorenko BL; Nemukhin AV; Shadrina MS; Topol IA; Burt SK
    Proteins; 2007 Feb; 66(2):456-66. PubMed ID: 17094109
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials.
    Khrenova MG; Bulavko ES; Mulashkin FD; Nemukhin AV
    Molecules; 2021 Jun; 26(13):. PubMed ID: 34208932
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Revisiting the structural flexibility of the complex p21(ras)-GTP: the catalytic conformation of the molecular switch II.
    Soares TA; Miller JH; Straatsma TP
    Proteins; 2001 Dec; 45(4):297-312. PubMed ID: 11746677
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dissection of the GTPase mechanism of Ras protein by MD analysis of Ras mutants.
    Friedman ZY; Devary Y
    Proteins; 2005 May; 59(3):528-33. PubMed ID: 15789417
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The hydration of Ras p21 in solution during GTP hydrolysis based on solution X-ray scattering profile.
    Fujisawa T; Uruga T; Yamaizumi Z; Inoko Y; Nishimura S; Ueki T
    J Biochem; 1994 May; 115(5):875-80. PubMed ID: 7961601
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Role of Gln61 in HRas GTP hydrolysis: a quantum mechanics/molecular mechanics study.
    Martín-García F; Mendieta-Moreno JI; López-Viñas E; Gómez-Puertas P; Mendieta J
    Biophys J; 2012 Jan; 102(1):152-7. PubMed ID: 22225809
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Modeling the role of G12V and G13V Ras mutations in the Ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate.
    Khrenova MG; Mironov VA; Grigorenko BL; Nemukhin AV
    Biochemistry; 2014 Nov; 53(45):7093-9. PubMed ID: 25339142
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Quantitative Measurement of Intrinsic GTP Hydrolysis for Carcinogenic Glutamine 61 Mutants in H-Ras.
    Novelli ET; First JT; Webb LJ
    Biochemistry; 2018 Nov; 57(44):6356-6366. PubMed ID: 30339365
    [TBL] [Abstract][Full Text] [Related]  

  • 12. QM/MM modeling the Ras-GAP catalyzed hydrolysis of guanosine triphosphate.
    Grigorenko BL; Nemukhin AV; Topol IA; Cachau RE; Burt SK
    Proteins; 2005 Aug; 60(3):495-503. PubMed ID: 15906320
    [TBL] [Abstract][Full Text] [Related]  

  • 13. On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins.
    Langen R; Schweins T; Warshel A
    Biochemistry; 1992 Sep; 31(37):8691-6. PubMed ID: 1390653
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Theoretical IR spectroscopy based on QM/MM calculations provides changes in charge distribution, bond lengths, and bond angles of the GTP ligand induced by the Ras-protein.
    Klähn M; Schlitter J; Gerwert K
    Biophys J; 2005 Jun; 88(6):3829-44. PubMed ID: 15805169
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.
    Frech M; Darden TA; Pedersen LG; Foley CK; Charifson PS; Anderson MW; Wittinghofer A
    Biochemistry; 1994 Mar; 33(11):3237-44. PubMed ID: 8136358
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism.
    Futatsugi N; Tsuda M
    Biophys J; 2001 Dec; 81(6):3483-8. PubMed ID: 11721009
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.
    Resat H; Straatsma TP; Dixon DA; Miller JH
    Proc Natl Acad Sci U S A; 2001 May; 98(11):6033-8. PubMed ID: 11371635
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of magnesium for geometry and charge in GTP hydrolysis, revealed by quantum mechanics/molecular mechanics simulations.
    Rudack T; Xia F; Schlitter J; Kötting C; Gerwert K
    Biophys J; 2012 Jul; 103(2):293-302. PubMed ID: 22853907
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21.
    Futatsugi N; Hata M; Hoshino T; Tsuda M
    Biophys J; 1999 Dec; 77(6):3287-92. PubMed ID: 10585950
    [TBL] [Abstract][Full Text] [Related]  

  • 20. X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.
    Privé GG; Milburn MV; Tong L; de Vos AM; Yamaizumi Z; Nishimura S; Kim SH
    Proc Natl Acad Sci U S A; 1992 Apr; 89(8):3649-53. PubMed ID: 1565661
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.