BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

390 related articles for article (PubMed ID: 30992500)

  • 1. Analysis of tractable allosteric sites in G protein-coupled receptors.
    Wakefield AE; Mason JS; Vajda S; Keserű GM
    Sci Rep; 2019 Apr; 9(1):6180. PubMed ID: 30992500
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors.
    Wakefield AE; Bajusz D; Kozakov D; Keserű GM; Vajda S
    J Chem Inf Model; 2022 Oct; 62(20):4937-4954. PubMed ID: 36195573
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu
    Orgován Z; Ferenczy GG; Keserű GM
    J Comput Aided Mol Des; 2019 Sep; 33(9):787-797. PubMed ID: 31542869
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Strategies for the identification of allosteric modulators of G-protein-coupled receptors.
    Burford NT; Watson J; Bertekap R; Alt A
    Biochem Pharmacol; 2011 Mar; 81(6):691-702. PubMed ID: 21184747
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel Allosteric Modulators of G Protein-coupled Receptors.
    Gentry PR; Sexton PM; Christopoulos A
    J Biol Chem; 2015 Aug; 290(32):19478-88. PubMed ID: 26100627
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions.
    Lu S; Zhang J
    J Med Chem; 2019 Jan; 62(1):24-45. PubMed ID: 29457894
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Emerging opportunities for allosteric modulation of G-protein coupled receptors.
    Wang CI; Lewis RJ
    Biochem Pharmacol; 2013 Jan; 85(2):153-62. PubMed ID: 22975406
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors.
    Zhang L; Mobbs JI; May LT; Glukhova A; Thal DM
    Curr Opin Struct Biol; 2023 Apr; 79():102560. PubMed ID: 36848776
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Intracellular Receptor Modulation: Novel Approach to Target GPCRs.
    Ortiz Zacarías NV; Lenselink EB; IJzerman AP; Handel TM; Heitman LH
    Trends Pharmacol Sci; 2018 Jun; 39(6):547-559. PubMed ID: 29653834
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Allosteric modulation of G protein-coupled receptors.
    May LT; Leach K; Sexton PM; Christopoulos A
    Annu Rev Pharmacol Toxicol; 2007; 47():1-51. PubMed ID: 17009927
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Molecular Basis of G Protein-Coupled Receptor Activation.
    Weis WI; Kobilka BK
    Annu Rev Biochem; 2018 Jun; 87():897-919. PubMed ID: 29925258
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry.
    Fronik P; Gaiser BI; Sejer Pedersen D
    J Med Chem; 2017 May; 60(10):4126-4134. PubMed ID: 28140580
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Allosteric modulation of G-protein coupled receptors.
    Jensen AA; Spalding TA
    Eur J Pharm Sci; 2004 Mar; 21(4):407-20. PubMed ID: 14998571
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Peptide recognition, signaling and modulation of class B G protein-coupled receptors.
    Cao C; Zhang H; Yang Z; Wu B
    Curr Opin Struct Biol; 2018 Aug; 51():53-60. PubMed ID: 29567494
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Application of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein-Coupled Receptors.
    Chan WKB; Carlson HA; Traynor JR
    Mol Pharmacol; 2023 May; 103(5):274-285. PubMed ID: 36868791
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Allosteric Modulators of the Class A G Protein Coupled Receptors.
    Tschammer N
    Adv Exp Med Biol; 2016; 917():185-207. PubMed ID: 27236557
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Is there a common allosteric binding site for G-protein coupled receptors?
    Malik F; Li Z
    J Comput Aided Mol Des; 2022 Jun; 36(6):405-413. PubMed ID: 35507106
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Potential for the Rational Design of Allosteric Modulators of Class C GPCRs.
    Christopher JA; Doré AS; Tehan BG
    Curr Top Med Chem; 2017; 17(1):71-78. PubMed ID: 27448651
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors.
    Valant C; Robert Lane J; Sexton PM; Christopoulos A
    Annu Rev Pharmacol Toxicol; 2012; 52():153-78. PubMed ID: 21910627
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacologically targeting intracellular allosteric sites of GPCRs for drug discovery.
    Zhang M; Lan X; Li X; Lu S
    Drug Discov Today; 2023 Dec; 28(12):103803. PubMed ID: 37852356
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.