BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

917 related articles for article (PubMed ID: 31035491)

  • 1. Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
    Strowitzki MJ; Cummins EP; Taylor CT
    Cells; 2019 Apr; 8(5):. PubMed ID: 31035491
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.
    Koivunen P; Hirsilä M; Günzler V; Kivirikko KI; Myllyharju J
    J Biol Chem; 2004 Mar; 279(11):9899-904. PubMed ID: 14701857
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.
    Tarhonskaya H; Hardy AP; Howe EA; Loik ND; Kramer HB; McCullagh JS; Schofield CJ; Flashman E
    J Biol Chem; 2015 Aug; 290(32):19726-42. PubMed ID: 26112411
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
    Wu Y; Li Z; McDonough MA; Schofield CJ; Zhang X
    J Med Chem; 2021 Jun; 64(11):7189-7209. PubMed ID: 34029087
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
    Flashman E; Davies SL; Yeoh KK; Schofield CJ
    Biochem J; 2010 Mar; 427(1):135-42. PubMed ID: 20055761
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.
    Chan MC; Ilott NE; Schödel J; Sims D; Tumber A; Lippl K; Mole DR; Pugh CW; Ratcliffe PJ; Ponting CP; Schofield CJ
    J Biol Chem; 2016 Sep; 291(39):20661-73. PubMed ID: 27502280
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The non-canonical functions of HIF prolyl hydroxylases and their dual roles in cancer.
    Yu M; Lun J; Zhang H; Zhu L; Zhang G; Fang J
    Int J Biochem Cell Biol; 2021 Jun; 135():105982. PubMed ID: 33894356
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
    Foxler DE; Bridge KS; James V; Webb TM; Mee M; Wong SC; Feng Y; Constantin-Teodosiu D; Petursdottir TE; Bjornsson J; Ingvarsson S; Ratcliffe PJ; Longmore GD; Sharp TV
    Nat Cell Biol; 2012 Jan; 14(2):201-8. PubMed ID: 22286099
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH; Stengel P; Doege K; Heikkinen P; Jokilehto T; Wagner T; Jelkmann W; Jaakkola P; Metzen E
    Biochem J; 2004 Aug; 381(Pt 3):761-7. PubMed ID: 15104534
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.
    Sang N; Fang J; Srinivas V; Leshchinsky I; Caro J
    Mol Cell Biol; 2002 May; 22(9):2984-92. PubMed ID: 11940656
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
    Hewitson KS; Schofield CJ; Ratcliffe PJ
    Methods Enzymol; 2007; 435():25-42. PubMed ID: 17998047
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biochemistry of the hypoxia-inducible factor hydroxylases.
    Fiorini G; Schofield CJ
    Curr Opin Chem Biol; 2024 Apr; 79():102428. PubMed ID: 38330792
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
    Stolze IP; Tian YM; Appelhoff RJ; Turley H; Wykoff CC; Gleadle JM; Ratcliffe PJ
    J Biol Chem; 2004 Oct; 279(41):42719-25. PubMed ID: 15302861
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.
    Pappalardi MB; McNulty DE; Martin JD; Fisher KE; Jiang Y; Burns MC; Zhao H; Ho T; Sweitzer S; Schwartz B; Annan RS; Copeland RA; Tummino PJ; Luo L
    Biochem J; 2011 Jun; 436(2):363-9. PubMed ID: 21410436
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel Dioxygenases, HIF-α Specific Prolyl-hydroxylase and Asparanginyl-hydroxylase: O
    Park H
    Toxicol Res; 2008 Jun; 24(2):101-107. PubMed ID: 32038783
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model.
    Schmierer B; Novák B; Schofield CJ
    BMC Syst Biol; 2010 Oct; 4():139. PubMed ID: 20955552
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway.
    Chen DY; Fabrizio JA; Wilkins SE; Dave KA; Gorman JJ; Gleadle JM; Fleming SB; Peet DJ; Mercer AA
    J Virol; 2017 Jan; 91(1):. PubMed ID: 27795413
    [TBL] [Abstract][Full Text] [Related]  

  • 18. HIF hydroxylase pathways in cardiovascular physiology and medicine.
    Bishop T; Ratcliffe PJ
    Circ Res; 2015 Jun; 117(1):65-79. PubMed ID: 26089364
    [TBL] [Abstract][Full Text] [Related]  

  • 19. NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1α stabilization by inhibiting prolyl hydroxylases activity.
    Li YN; Xi MM; Guo Y; Hai CX; Yang WL; Qin XJ
    Toxicol Lett; 2014 Jan; 224(2):165-74. PubMed ID: 24188932
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.
    Kiriakidis S; Hoer SS; Burrows N; Biddlecome G; Khan MN; Thinnes CC; Schofield CJ; Rogers N; Botto M; Paleolog E; Maxwell PH
    Kidney Int; 2017 Oct; 92(4):900-908. PubMed ID: 28506759
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 46.