BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

278 related articles for article (PubMed ID: 31039129)

  • 1. Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
    Duan W; Guo M; Yi L; Zhang J; Bi Y; Liu Y; Li Y; Li Z; Ma Y; Zhang G; Liu Y; Song X; Li C
    Aging (Albany NY); 2019 Apr; 11(8):2457-2476. PubMed ID: 31039129
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.
    Gerbino V; Kaunga E; Ye J; Canzio D; O'Keeffe S; Rudnick ND; Guarnieri P; Lutz CM; Maniatis T
    Neuron; 2020 Jun; 106(5):789-805.e5. PubMed ID: 32220666
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration.
    Duan W; Yi L; Tian Y; Huang HP; Li Z; Bi Y; Guo M; Li Y; Liu Y; Ma Y; Song X; Liu Y; Li C
    Mol Neurobiol; 2021 May; 58(5):2435-2446. PubMed ID: 33439438
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.
    Catanese A; Olde Heuvel F; Mulaw M; Demestre M; Higelin J; Barbi G; Freischmidt A; Weishaupt JH; Ludolph AC; Roselli F; Boeckers TM
    Autophagy; 2019 Oct; 15(10):1719-1737. PubMed ID: 30939964
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway.
    Ciura S; Sellier C; Campanari ML; Charlet-Berguerand N; Kabashi E
    Autophagy; 2016 Aug; 12(8):1406-8. PubMed ID: 27245636
    [TBL] [Abstract][Full Text] [Related]  

  • 6. TBK1: a new player in ALS linking autophagy and neuroinflammation.
    Oakes JA; Davies MC; Collins MO
    Mol Brain; 2017 Feb; 10(1):5. PubMed ID: 28148298
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
    Brenner D; Sieverding K; Srinidhi J; Zellner S; Secker C; Yilmaz R; Dyckow J; Amr S; Ponomarenko A; Tunaboylu E; Douahem Y; Schlag JS; Rodríguez Martínez L; Kislinger G; Niemann C; Nalbach K; Ruf WP; Uhl J; Hollenbeck J; Schirmer L; Catanese A; Lobsiger CS; Danzer KM; Yilmazer-Hanke D; Münch C; Koch P; Freischmidt A; Fetting M; Behrends C; Parlato R; Weishaupt JH
    J Exp Med; 2024 May; 221(5):. PubMed ID: 38517332
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43
    Sieverding K; Ulmer J; Bruno C; Satoh T; Tsao W; Freischmidt A; Akira S; Wong PC; Ludolph AC; Danzer KM; Lobsiger CS; Brenner D; Weishaupt JH
    Exp Neurol; 2021 Jan; 335():113496. PubMed ID: 33038415
    [TBL] [Abstract][Full Text] [Related]  

  • 9. TBK1 mutation frequencies in French frontotemporal dementia and amyotrophic lateral sclerosis cohorts.
    Le Ber I; De Septenville A; Millecamps S; Camuzat A; Caroppo P; Couratier P; Blanc F; Lacomblez L; Sellal F; Fleury MC; Meininger V; Cazeneuve C; Clot F; Flabeau O; LeGuern E; Brice A;
    Neurobiol Aging; 2015 Nov; 36(11):3116.e5-3116.e8. PubMed ID: 26476236
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Association between TBK1 mutations and risk of amyotrophic lateral sclerosis/frontotemporal dementia spectrum: a meta-analysis.
    Cui R; Tuo M; Li P; Zhou C
    Neurol Sci; 2018 May; 39(5):811-820. PubMed ID: 29349657
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional and structural consequences of TBK1 missense variants in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
    Gurfinkel Y; Polain N; Sonar K; Nice P; Mancera RL; Rea SL
    Neurobiol Dis; 2022 Nov; 174():105859. PubMed ID: 36113750
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD.
    Higgins NR; Greenslade JE; Wu JJ; Miranda E; Galliciotti G; Monteiro MJ
    Brain Pathol; 2021 Sep; 31(5):e12948. PubMed ID: 33780087
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation.
    Foster AD; Downing P; Figredo E; Polain N; Stott A; Layfield R; Rea SL
    Mol Cell Neurosci; 2020 Oct; 108():103539. PubMed ID: 32835772
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Heterozygous
    Brenner D; Sieverding K; Bruno C; Lüningschrör P; Buck E; Mungwa S; Fischer L; Brockmann SJ; Ulmer J; Bliederhäuser C; Philibert CE; Satoh T; Akira S; Boillée S; Mayer B; Sendtner M; Ludolph AC; Danzer KM; Lobsiger CS; Freischmidt A; Weishaupt JH
    J Exp Med; 2019 Feb; 216(2):267-278. PubMed ID: 30635357
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
    Weishaupt JH; Hyman T; Dikic I
    Trends Mol Med; 2016 Sep; 22(9):769-783. PubMed ID: 27498188
    [TBL] [Abstract][Full Text] [Related]  

  • 16. TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
    van der Zee J; Gijselinck I; Van Mossevelde S; Perrone F; Dillen L; Heeman B; Bäumer V; Engelborghs S; De Bleecker J; Baets J; Gelpi E; Rojas-García R; Clarimón J; Lleó A; Diehl-Schmid J; Alexopoulos P; Perneczky R; Synofzik M; Just J; Schöls L; Graff C; Thonberg H; Borroni B; Padovani A; Jordanova A; Sarafov S; Tournev I; de Mendonça A; Miltenberger-Miltényi G; Simões do Couto F; Ramirez A; Jessen F; Heneka MT; Gómez-Tortosa E; Danek A; Cras P; Vandenberghe R; De Jonghe P; De Deyn PP; Sleegers K; Cruts M; Van Broeckhoven C; Goeman J; Nuytten D; Smets K; Robberecht W; Damme PV; Bleecker J; Santens P; Dermaut B; Versijpt J; Michotte A; Ivanoiu A; Deryck O; Bergmans B; Delbeck J; Bruyland M; Willems C; Salmon E; Pastor P; Ortega-Cubero S; Benussi L; Ghidoni R; Binetti G; Hernández I; Boada M; Ruiz A; Sorbi S; Nacmias B; Bagnoli S; Sorbi S; Sanchez-Valle R; Llado A; Santana I; Rosário Almeida M; Frisoni GB; Maetzler W; Matej R; Fraidakis MJ; Kovacs GG; Fabrizi GM; Testi S
    Hum Mutat; 2017 Mar; 38(3):297-309. PubMed ID: 28008748
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review.
    Yu H; Yu W; Luo SS; Yang YJ; Liu FT; Zhang Y; Chen Y; Sun YM; Wu JJ
    Mol Genet Genomic Med; 2019 Mar; 7(3):e547. PubMed ID: 30672142
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Human TBK1: A Gatekeeper of Neuroinflammation.
    Ahmad L; Zhang SY; Casanova JL; Sancho-Shimizu V
    Trends Mol Med; 2016 Jun; 22(6):511-527. PubMed ID: 27211305
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?
    Deng Z; Sheehan P; Chen S; Yue Z
    Mol Neurodegener; 2017 Dec; 12(1):90. PubMed ID: 29282133
    [TBL] [Abstract][Full Text] [Related]  

  • 20. OPTN gene therapy increases autophagy and protects mitochondria in SOD1-G93A-expressing transgenic mice and cells.
    Wen D; Ji Y; Li Y; Duan W; Wang Y; Li Z; Tao M; Liu Y
    FEBS J; 2024 Feb; 291(4):795-813. PubMed ID: 37983563
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.