These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 31044597)

  • 1. HIV Transcription Is Independent of Mediator Kinases.
    Cary DC; Rheinberger M; Rojc A; Peterlin BM
    AIDS Res Hum Retroviruses; 2019 Aug; 35(8):710-717. PubMed ID: 31044597
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.
    Audetat KA; Galbraith MD; Odell AT; Lee T; Pandey A; Espinosa JM; Dowell RD; Taatjes DJ
    Mol Cell Biol; 2017 Jul; 37(13):. PubMed ID: 28416637
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of target genes for the CDK subunits of the Mediator complex.
    Tsutsui T; Fukasawa R; Tanaka A; Hirose Y; Ohkuma Y
    Genes Cells; 2011 Dec; 16(12):1208-18. PubMed ID: 22117896
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.
    Steinparzer I; Sedlyarov V; Rubin JD; Eislmayr K; Galbraith MD; Levandowski CB; Vcelkova T; Sneezum L; Wascher F; Amman F; Kleinova R; Bender H; Andrysik Z; Espinosa JM; Superti-Furga G; Dowell RD; Taatjes DJ; Kovarik P
    Mol Cell; 2019 Nov; 76(3):485-499.e8. PubMed ID: 31495563
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    Park MJ; Shen H; Spaeth JM; Tolvanen JH; Failor C; Knudtson JF; McLaughlin J; Halder SK; Yang Q; Bulun SE; Al-Hendy A; Schenken RS; Aaltonen LA; Boyer TG
    J Biol Chem; 2018 Mar; 293(13):4870-4882. PubMed ID: 29440396
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.
    Butler M; Chotiwan N; Brewster CD; DiLisio JE; Ackart DF; Podell BK; Basaraba RJ; Perera R; Quackenbush SL; Rovnak J
    Viruses; 2020 Jun; 12(6):. PubMed ID: 32560467
    [TBL] [Abstract][Full Text] [Related]  

  • 7. CDK8 Kinase Activity Promotes Glycolysis.
    Galbraith MD; Andrysik Z; Pandey A; Hoh M; Bonner EA; Hill AA; Sullivan KD; Espinosa JM
    Cell Rep; 2017 Nov; 21(6):1495-1506. PubMed ID: 29117556
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
    Pelish HE; Liau BB; Nitulescu II; Tangpeerachaikul A; Poss ZC; Da Silva DH; Caruso BT; Arefolov A; Fadeyi O; Christie AL; Du K; Banka D; Schneider EV; Jestel A; Zou G; Si C; Ebmeier CC; Bronson RT; Krivtsov AV; Myers AG; Kohl NE; Kung AL; Armstrong SA; Lemieux ME; Taatjes DJ; Shair MD
    Nature; 2015 Oct; 526(7572):273-276. PubMed ID: 26416749
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.
    Tsutsui T; Fukasawa R; Shinmyouzu K; Nakagawa R; Tobe K; Tanaka A; Ohkuma Y
    J Biol Chem; 2013 Jul; 288(29):20955-20965. PubMed ID: 23749998
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
    Dale T; Clarke PA; Esdar C; Waalboer D; Adeniji-Popoola O; Ortiz-Ruiz MJ; Mallinger A; Samant RS; Czodrowski P; Musil D; Schwarz D; Schneider K; Stubbs M; Ewan K; Fraser E; TePoele R; Court W; Box G; Valenti M; de Haven Brandon A; Gowan S; Rohdich F; Raynaud F; Schneider R; Poeschke O; Blaukat A; Workman P; Schiemann K; Eccles SA; Wienke D; Blagg J
    Nat Chem Biol; 2015 Dec; 11(12):973-980. PubMed ID: 26502155
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition.
    Chen M; Li J; Liang J; Thompson ZS; Kathrein K; Broude EV; Roninson IB
    Cells; 2019 Nov; 8(11):. PubMed ID: 31717492
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.
    Chen M; Liang J; Ji H; Yang Z; Altilia S; Hu B; Schronce A; McDermott MSJ; Schools GP; Lim CU; Oliver D; Shtutman MS; Lu T; Stark GR; Porter DC; Broude EV; Roninson IB
    Proc Natl Acad Sci U S A; 2017 Sep; 114(38):10208-10213. PubMed ID: 28855340
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mediator kinase inhibition reverses castration resistance of advanced prostate cancer.
    Li J; Hilimire TA; Liu Y; Wang L; Liang J; Gyorffy B; Sikirzhytski V; Ji H; Zhang L; Cheng C; Ding X; Kerr KR; Dowling CE; Chumanevich AA; Mack ZT; Schools GP; Lim CU; Ellis L; Zi X; Porter DC; Broude EV; McInnes C; Wilding G; Lilly MB; Roninson IB; Chen M
    J Clin Invest; 2024 Mar; 134(10):. PubMed ID: 38546787
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting "block and lock" treatment strategies.
    Horvath RM; Brumme ZL; Sadowski I
    Antimicrob Agents Chemother; 2024 Mar; 68(3):e0107223. PubMed ID: 38319085
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay.
    Li J; Ji H; Porter DC; Broude EV; Roninson IB; Chen M
    Cells; 2019 Oct; 8(10):. PubMed ID: 31590445
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.
    Fukasawa R; Iida S; Tsutsui T; Hirose Y; Ohkuma Y
    J Biochem; 2015 Nov; 158(5):373-84. PubMed ID: 26002960
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
    Brägelmann J; Klümper N; Offermann A; von Mässenhausen A; Böhm D; Deng M; Queisser A; Sanders C; Syring I; Merseburger AS; Vogel W; Sievers E; Vlasic I; Carlsson J; Andrén O; Brossart P; Duensing S; Svensson MA; Adler D; Kirfel J; Perner S
    Clin Cancer Res; 2017 Apr; 23(7):1829-1840. PubMed ID: 27678455
    [No Abstract]   [Full Text] [Related]  

  • 18. Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.
    Lynch CJ; Bernad R; Martínez-Val A; Shahbazi MN; Nóbrega-Pereira S; Calvo I; Blanco-Aparicio C; Tarantino C; Garreta E; Richart-Ginés L; Alcazar N; Graña-Castro O; Gómez-Lopez G; Aksoy I; Muñoz-Martín M; Martinez S; Ortega S; Prieto S; Simboeck E; Camasses A; Stephan-Otto Attolini C; Fernandez AF; Sierra MI; Fraga MF; Pastor J; Fisher D; Montserrat N; Savatier P; Muñoz J; Zernicka-Goetz M; Serrano M
    Nat Cell Biol; 2020 Oct; 22(10):1223-1238. PubMed ID: 32989249
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.
    Yamamoto S; Hagihara T; Horiuchi Y; Okui A; Wani S; Yoshida T; Inoue T; Tanaka A; Ito T; Hirose Y; Ohkuma Y
    Genes Cells; 2017 Mar; 22(3):265-276. PubMed ID: 28151579
    [TBL] [Abstract][Full Text] [Related]  

  • 20. CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.
    Dannappel MV; Zhu D; Sun X; Chua HK; Poppelaars M; Suehiro M; Khadka S; Lim Kam Sian TC; Sooraj D; Loi M; Gao H; Croagh D; Daly RJ; Faridi P; Boyer TG; Firestein R
    J Clin Invest; 2022 Oct; 132(20):. PubMed ID: 36006697
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.