151 related articles for article (PubMed ID: 31056264)
1. A novel mechanism of irinotecan targeting MDM2 and Bcl-xL.
Lee B; Min JA; Nashed A; Lee SO; Yoo JC; Chi SW; Yi GS
Biochem Biophys Res Commun; 2019 Jun; 514(2):518-523. PubMed ID: 31056264
[TBL] [Abstract][Full Text] [Related]
2. Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.
Kojima K; Konopleva M; Samudio IJ; Schober WD; Bornmann WG; Andreeff M
Cell Cycle; 2006 Dec; 5(23):2778-86. PubMed ID: 17172851
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosis.
Bhattacharya S; Ray RM; Chaum E; Johnson DA; Johnson LR
Invest Ophthalmol Vis Sci; 2011 May; 52(6):3368-80. PubMed ID: 21345989
[TBL] [Abstract][Full Text] [Related]
4. Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins.
Lee MS; Ha JH; Yoon HS; Lee CK; Chi SW
Biochem Biophys Res Commun; 2014 Feb; 445(1):120-5. PubMed ID: 24491548
[TBL] [Abstract][Full Text] [Related]
5. Targeting of p53 peptide analogues to anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy.
Shin JS; Ha JH; Chi SW
Biochem Biophys Res Commun; 2014 Jan; 443(3):882-7. PubMed ID: 24342622
[TBL] [Abstract][Full Text] [Related]
6. Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.
Zhang J; Huang K; O'Neill KL; Pang X; Luo X
Cell Death Dis; 2016 Jun; 7(6):e2266. PubMed ID: 27310874
[TBL] [Abstract][Full Text] [Related]
7. PI3K/mTOR dual inhibitor NVP-BEZ235 decreases Mcl-1 expression and sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies, provided that Bim expression is induced.
Jebahi A; Villedieu M; Pétigny-Lechartier C; Brotin E; Louis MH; Abeilard E; Giffard F; Guercio M; Briand M; Gauduchon P; Lheureux S; Poulain L
Cancer Lett; 2014 Jun; 348(1-2):38-49. PubMed ID: 24650799
[TBL] [Abstract][Full Text] [Related]
8. Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells.
Rigatti MJ; Verma R; Belinsky GS; Rosenberg DW; Giardina C
Mol Carcinog; 2012 May; 51(5):363-78. PubMed ID: 21557332
[TBL] [Abstract][Full Text] [Related]
9. Wilms' tumor gene 1 enhances nutlin-3-induced apoptosis.
Lee SY; Choe YJ; Park JY; Lee SS; Kim YH; Shin SJ; Chung YJ; Kim HS
Oncol Rep; 2014 Jan; 31(1):131-6. PubMed ID: 24190574
[TBL] [Abstract][Full Text] [Related]
10. Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis.
Pujals A; Renouf B; Robert A; Chelouah S; Hollville E; Wiels J
Cell Death Dis; 2011 Jul; 2(7):e184. PubMed ID: 21796156
[TBL] [Abstract][Full Text] [Related]
11. Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL.
Hari Y; Harashima N; Tajima Y; Harada M
Oncotarget; 2015 Dec; 6(39):41902-15. PubMed ID: 26506422
[TBL] [Abstract][Full Text] [Related]
12. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.
Yosef R; Pilpel N; Tokarsky-Amiel R; Biran A; Ovadya Y; Cohen S; Vadai E; Dassa L; Shahar E; Condiotti R; Ben-Porath I; Krizhanovsky V
Nat Commun; 2016 Apr; 7():11190. PubMed ID: 27048913
[TBL] [Abstract][Full Text] [Related]
13. Structural insights into the dual-targeting mechanism of Nutlin-3.
Shin JS; Ha JH; He F; Muto Y; Ryu KS; Yoon HS; Kang S; Park SG; Park BC; Choi SU; Chi SW
Biochem Biophys Res Commun; 2012 Mar; 420(1):48-53. PubMed ID: 22402281
[TBL] [Abstract][Full Text] [Related]
14. The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib.
Hikita H; Takehara T; Shimizu S; Kodama T; Shigekawa M; Iwase K; Hosui A; Miyagi T; Tatsumi T; Ishida H; Li W; Kanto T; Hiramatsu N; Hayashi N
Hepatology; 2010 Oct; 52(4):1310-21. PubMed ID: 20799354
[TBL] [Abstract][Full Text] [Related]
15. Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL.
Le Pen J; Maillet L; Sarosiek K; Vuillier C; Gautier F; Montessuit S; Martinou JC; Letaï A; Braun F; Juin PP
Cell Death Dis; 2016 Feb; 7(2):e2083. PubMed ID: 26844698
[TBL] [Abstract][Full Text] [Related]
16. Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53.
Yang MC; Lin RW; Huang SB; Huang SY; Chen WJ; Wang S; Hong YR; Wang C
Cell Cycle; 2016; 15(3):394-402. PubMed ID: 26694174
[TBL] [Abstract][Full Text] [Related]
17.
Al-Ghabkari A; Narendran A
Cancer Biother Radiopharm; 2019 May; 34(4):252-257. PubMed ID: 30724592
[No Abstract] [Full Text] [Related]
18. Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.
Sriraman A; Radovanovic M; Wienken M; Najafova Z; Li Y; Dobbelstein M
Oncotarget; 2016 May; 7(22):31623-38. PubMed ID: 27183917
[TBL] [Abstract][Full Text] [Related]
19. Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction.
Zhang L; Zhang J; Hu C; Cao J; Zhou X; Hu Y; He Q; Yang B
Anticancer Drugs; 2009 Jul; 20(6):416-24. PubMed ID: 19579266
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple myeloma, and acts synergistically with ABT-737.
Gu D; Wang S; Kuiatse I; Wang H; He J; Dai Y; Jones RJ; Bjorklund CC; Yang J; Grant S; Orlowski RZ
PLoS One; 2014; 9(9):e103015. PubMed ID: 25181509
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]