BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

400 related articles for article (PubMed ID: 31056398)

  • 1. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
    Ishizawa J; Zarabi SF; Davis RE; Halgas O; Nii T; Jitkova Y; Zhao R; St-Germain J; Heese LE; Egan G; Ruvolo VR; Barghout SH; Nishida Y; Hurren R; Ma W; Gronda M; Link T; Wong K; Mabanglo M; Kojima K; Borthakur G; MacLean N; Ma MCJ; Leber AB; Minden MD; Houry W; Kantarjian H; Stogniew M; Raught B; Pai EF; Schimmer AD; Andreeff M
    Cancer Cell; 2019 May; 35(5):721-737.e9. PubMed ID: 31056398
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
    Mabanglo MF; Wong KS; Barghash MM; Leung E; Chuang SHW; Ardalan A; Majaesic EM; Wong CJ; Zhang S; Lang H; Karanewsky DS; Iwanowicz AA; Graves LM; Iwanowicz EJ; Gingras AC; Houry WA
    Structure; 2023 Feb; 31(2):185-200.e10. PubMed ID: 36586405
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.
    Jacques S; van der Sloot AM; C Huard C; Coulombe-Huntington J; Tsao S; Tollis S; Bertomeu T; Culp EJ; Pallant D; Cook MA; Bonneil E; Thibault P; Wright GD; Tyers M
    Genetics; 2020 Apr; 214(4):1103-1120. PubMed ID: 32094149
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists.
    Zhang R; Wang P; Wei B; Chen L; Song X; Pan Y; Li J; Gan J; Zhang T; Yang CG
    Eur J Med Chem; 2023 Oct; 258():115577. PubMed ID: 37352796
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues.
    Graves PR; Aponte-Collazo LJ; Fennell EMJ; Graves AC; Hale AE; Dicheva N; Herring LE; Gilbert TSK; East MP; McDonald IM; Lockett MR; Ashamalla H; Moorman NJ; Karanewsky DS; Iwanowicz EJ; Holmuhamedov E; Graves LM
    ACS Chem Biol; 2019 May; 14(5):1020-1029. PubMed ID: 31021596
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer.
    Cormio A; Sanguedolce F; Pesce V; Musicco C
    Int J Mol Sci; 2021 Jun; 22(12):. PubMed ID: 34207660
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma.
    Nguyen TTT; Shang E; Schiffgens S; Torrini C; Shu C; Akman HO; Prabhu VV; Allen JE; Westhoff MA; Karpel-Massler G; Siegelin MD
    Clin Cancer Res; 2022 May; 28(9):1881-1895. PubMed ID: 35417530
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
    Cole A; Wang Z; Coyaud E; Voisin V; Gronda M; Jitkova Y; Mattson R; Hurren R; Babovic S; Maclean N; Restall I; Wang X; Jeyaraju DV; Sukhai MA; Prabha S; Bashir S; Ramakrishnan A; Leung E; Qia YH; Zhang N; Combes KR; Ketela T; Lin F; Houry WA; Aman A; Al-Awar R; Zheng W; Wienholds E; Xu CJ; Dick J; Wang JC; Moffat J; Minden MD; Eaves CJ; Bader GD; Hao Z; Kornblau SM; Raught B; Schimmer AD
    Cancer Cell; 2015 Jun; 27(6):864-76. PubMed ID: 26058080
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure.
    Ni T; Ye F; Liu X; Zhang J; Liu H; Li J; Zhang Y; Sun Y; Wang M; Luo C; Jiang H; Lan L; Gan J; Zhang A; Zhou H; Yang CG
    ACS Chem Biol; 2016 Jul; 11(7):1964-72. PubMed ID: 27171654
    [TBL] [Abstract][Full Text] [Related]  

  • 10. ONC201 and imipridones: Anti-cancer compounds with clinical efficacy.
    Prabhu VV; Morrow S; Rahman Kawakibi A; Zhou L; Ralff M; Ray J; Jhaveri A; Ferrarini I; Lee Y; Parker C; Zhang Y; Borsuk R; Chang WI; Honeyman JN; Tavora F; Carneiro B; Raufi A; Huntington K; Carlsen L; Louie A; Safran H; Seyhan AA; Tarapore RS; Schalop L; Stogniew M; Allen JE; Oster W; El-Deiry WS
    Neoplasia; 2020 Dec; 22(12):725-744. PubMed ID: 33142238
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Selective Activation of Human Caseinolytic Protease P (ClpP).
    Stahl M; Korotkov VS; Balogh D; Kick LM; Gersch M; Pahl A; Kielkowski P; Richter K; Schneider S; Sieber SA
    Angew Chem Int Ed Engl; 2018 Oct; 57(44):14602-14607. PubMed ID: 30129683
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis.
    Rumyantseva A; Popovic M; Trifunovic A
    Brain; 2022 Mar; 145(1):92-104. PubMed ID: 35240691
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP.
    Fennell EMJ; Aponte-Collazo LJ; Wynn JD; Drizyte-Miller K; Leung E; Greer YE; Graves PR; Iwanowicz AA; Ashamalla H; Holmuhamedov E; Lang H; Karanewsky DS; Der CJ; Houry WA; Lipkowitz S; Iwanowicz EJ; Graves LM
    Pharmacol Res Perspect; 2022 Aug; 10(4):e00993. PubMed ID: 35929764
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site.
    Szyk A; Maurizi MR
    J Struct Biol; 2006 Oct; 156(1):165-74. PubMed ID: 16682229
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Initial Characterization of the Two ClpP Paralogs of
    Wood NA; Chung KY; Blocker AM; Rodrigues de Almeida N; Conda-Sheridan M; Fisher DJ; Ouellette SP
    J Bacteriol; 2019 Jan; 201(2):. PubMed ID: 30396899
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Perrault syndrome type 3 caused by diverse molecular defects in CLPP.
    Brodie EJ; Zhan H; Saiyed T; Truscott KN; Dougan DA
    Sci Rep; 2018 Aug; 8(1):12862. PubMed ID: 30150665
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Loss of conserved mitochondrial CLPP and its functions lead to different phenotypes in plants and other organisms.
    Huang S; Petereit J; Millar AH
    Plant Signal Behav; 2020 Dec; 15(12):1831789. PubMed ID: 33073672
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization.
    Hackl MW; Lakemeyer M; Dahmen M; Glaser M; Pahl A; Lorenz-Baath K; Menzel T; Sievers S; Böttcher T; Antes I; Waldmann H; Sieber SA
    J Am Chem Soc; 2015 Jul; 137(26):8475-83. PubMed ID: 26083639
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Arginine phosphorylation marks proteins for degradation by a Clp protease.
    Trentini DB; Suskiewicz MJ; Heuck A; Kurzbauer R; Deszcz L; Mechtler K; Clausen T
    Nature; 2016 Nov; 539(7627):48-53. PubMed ID: 27749819
    [TBL] [Abstract][Full Text] [Related]  

  • 20. IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro.
    Zhang J; Luo B; Sui J; Qiu Z; Huang J; Yang T; Luo Y
    Biochem Pharmacol; 2022 Oct; 204():115232. PubMed ID: 36030831
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.