BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

843 related articles for article (PubMed ID: 31059647)

  • 1. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications.
    Ward CC; Kleinman JI; Brittain SM; Lee PS; Chung CYS; Kim K; Petri Y; Thomas JR; Tallarico JA; McKenna JM; Schirle M; Nomura DK
    ACS Chem Biol; 2019 Nov; 14(11):2430-2440. PubMed ID: 31059647
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications.
    Henning NJ; Manford AG; Spradlin JN; Brittain SM; Zhang E; McKenna JM; Tallarico JA; Schirle M; Rape M; Nomura DK
    J Am Chem Soc; 2022 Jan; 144(2):701-708. PubMed ID: 34994556
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ligandability of E3 Ligases for Targeted Protein Degradation Applications.
    Belcher BP; Ward CC; Nomura DK
    Biochemistry; 2023 Feb; 62(3):588-600. PubMed ID: 34473924
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeted Protein Degradation through E2 Recruitment.
    Forte N; Dovala D; Hesse MJ; McKenna JM; Tallarico JA; Schirle M; Nomura DK
    ACS Chem Biol; 2023 Apr; 18(4):897-904. PubMed ID: 36940189
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation.
    Hong SH; Divakaran A; Osa A; Huang OW; Wertz IE; Nomura DK
    ACS Chem Biol; 2024 Feb; 19(2):442-450. PubMed ID: 38305738
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Bardoxolone conjugation enables targeted protein degradation of BRD4.
    Tong B; Luo M; Xie Y; Spradlin JN; Tallarico JA; McKenna JM; Schirle M; Maimone TJ; Nomura DK
    Sci Rep; 2020 Sep; 10(1):15543. PubMed ID: 32968148
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1.
    Meyers M; Cismoski S; Panidapu A; Chie-Leon B; Nomura DK
    ACS Chem Biol; 2024 Jan; 19(1):58-68. PubMed ID: 38192078
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function.
    Luo M; Spradlin JN; Boike L; Tong B; Brittain SM; McKenna JM; Tallarico JA; Schirle M; Maimone TJ; Nomura DK
    Cell Chem Biol; 2021 Apr; 28(4):559-566.e15. PubMed ID: 33513350
    [TBL] [Abstract][Full Text] [Related]  

  • 9. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.
    Ishida T; Ciulli A
    SLAS Discov; 2021 Apr; 26(4):484-502. PubMed ID: 33143537
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeted protein degradation and the enzymology of degraders.
    Fisher SL; Phillips AJ
    Curr Opin Chem Biol; 2018 Jun; 44():47-55. PubMed ID: 29885948
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeted protein degradation via intramolecular bivalent glues.
    Hsia O; Hinterndorfer M; Cowan AD; Iso K; Ishida T; Sundaramoorthy R; Nakasone MA; Imrichova H; Schätz C; Rukavina A; Husnjak K; Wegner M; Correa-Sáez A; Craigon C; Casement R; Maniaci C; Testa A; Kaulich M; Dikic I; Winter GE; Ciulli A
    Nature; 2024 Mar; 627(8002):204-211. PubMed ID: 38383787
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Perspectives on the development of first-in-class protein degraders.
    Rambacher KM; Calabrese MF; Yamaguchi M
    Future Med Chem; 2021 Jul; 13(14):1203-1226. PubMed ID: 34015962
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The rise of covalent proteolysis targeting chimeras.
    Gabizon R; London N
    Curr Opin Chem Biol; 2021 Jun; 62():24-33. PubMed ID: 33549806
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.
    Rothweiler EM; Brennan PE; Huber KVM
    Biol Chem; 2022 Mar; 403(4):391-402. PubMed ID: 35191283
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Small-Molecule Degraders beyond PROTACs-Challenges and Opportunities.
    Kastl JM; Davies G; Godsman E; Holdgate GA
    SLAS Discov; 2021 Apr; 26(4):524-533. PubMed ID: 33632029
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay.
    Foley CA; Potjewyd F; Lamb KN; James LI; Frye SV
    ACS Chem Biol; 2020 Jan; 15(1):290-295. PubMed ID: 31846298
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
    Akuffo AA; Alontaga AY; Metcalf R; Beatty MS; Becker A; McDaniel JM; Hesterberg RS; Goodheart WE; Gunawan S; Ayaz M; Yang Y; Karim MR; Orobello ME; Daniel K; Guida W; Yoder JA; Rajadhyaksha AM; Schönbrunn E; Lawrence HR; Lawrence NJ; Epling-Burnette PK
    J Biol Chem; 2018 Apr; 293(16):6187-6200. PubMed ID: 29449372
    [TBL] [Abstract][Full Text] [Related]  

  • 18. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
    Tatham MH; Geoffroy MC; Shen L; Plechanovova A; Hattersley N; Jaffray EG; Palvimo JJ; Hay RT
    Nat Cell Biol; 2008 May; 10(5):538-46. PubMed ID: 18408734
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB.
    King EA; Cho Y; Hsu NS; Dovala D; McKenna JM; Tallarico JA; Schirle M; Nomura DK
    Cell Chem Biol; 2023 Apr; 30(4):394-402.e9. PubMed ID: 36898369
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs.
    Shah RR; De Vita E; Sathyamurthi PS; Conole D; Zhang X; Fellows E; Dickinson ER; Fleites CM; Queisser MA; Harling JD; Tate EW
    J Med Chem; 2024 Mar; 67(6):4641-4654. PubMed ID: 38478885
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 43.