119 related articles for article (PubMed ID: 31061338)
21. Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes.
Park HJ; Choi YJ; Kim JW; Chun HS; Im I; Yoon S; Han YM; Song CW; Kim H
PLoS One; 2015; 10(7):e0132992. PubMed ID: 26177506
[TBL] [Abstract][Full Text] [Related]
22. Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS).
Steuer AE; Williner E; Staeheli SN; Kraemer T
Drug Test Anal; 2017 Jul; 9(7):1085-1092. PubMed ID: 27736030
[TBL] [Abstract][Full Text] [Related]
23. Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics.
Shen HW; Wu C; Jiang XL; Yu AM
Biochem Pharmacol; 2010 Jul; 80(1):122-8. PubMed ID: 20206139
[TBL] [Abstract][Full Text] [Related]
24. Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver.
Sanoh S; Horiguchi A; Sugihara K; Kotake Y; Tayama Y; Ohshita H; Tateno C; Horie T; Kitamura S; Ohta S
Drug Metab Dispos; 2012 Feb; 40(2):322-8. PubMed ID: 22048522
[TBL] [Abstract][Full Text] [Related]
25. Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes.
Okuyama S; Mine A; Nakamura T; Ohasi Y; Seto M; Tada M
Pharmacol Res Perspect; 2022 Apr; 10(2):e00939. PubMed ID: 35174659
[TBL] [Abstract][Full Text] [Related]
26. A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells.
Klein M; Thomas M; Hofmann U; Seehofer D; Damm G; Zanger UM
Drug Metab Dispos; 2015 Feb; 43(2):273-83. PubMed ID: 25480923
[TBL] [Abstract][Full Text] [Related]
27. Human hepatoma HepaRG cell line engraftment in severe combined immunodeficient × beige mice using mouse-specific anti-Fas antibody.
Jiang L; Li JG; Lan L; Wang YM; Mao Q; You JP
Transplant Proc; 2010 Nov; 42(9):3773-8. PubMed ID: 21094855
[TBL] [Abstract][Full Text] [Related]
28. Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines.
Kvist AJ; Kanebratt KP; Walentinsson A; Palmgren H; O'Hara M; Björkbom A; Andersson LC; Ahlqvist M; Andersson TB
Biochem Pharmacol; 2018 Sep; 155():124-140. PubMed ID: 29953844
[TBL] [Abstract][Full Text] [Related]
29. Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.
Kratochwil NA; Meille C; Fowler S; Klammers F; Ekiciler A; Molitor B; Simon S; Walter I; McGinnis C; Walther J; Leonard B; Triyatni M; Javanbakht H; Funk C; Schuler F; Lavé T; Parrott NJ
AAPS J; 2017 Mar; 19(2):534-550. PubMed ID: 28050713
[TBL] [Abstract][Full Text] [Related]
30. First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry.
Wohlfarth A; Pang S; Zhu M; Gandhi AS; Scheidweiler KB; Liu HF; Huestis MA
Clin Chem; 2013 Nov; 59(11):1638-48. PubMed ID: 24014837
[TBL] [Abstract][Full Text] [Related]
31. A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers.
Watari R; Kakiki M; Oshikata A; Takezawa T; Yamasaki C; Ishida Y; Tateno C; Kuroda Y; Ishida S; Kusano K
J Toxicol Sci; 2018; 43(8):521-529. PubMed ID: 30078838
[TBL] [Abstract][Full Text] [Related]
32. Establishment of a Drug-Induced, Bile Acid-Dependent Hepatotoxicity Model Using HepaRG Cells.
Susukida T; Sekine S; Nozaki M; Tokizono M; Oizumi K; Horie T; Ito K
J Pharm Sci; 2016 Apr; 105(4):1550-60. PubMed ID: 26952880
[TBL] [Abstract][Full Text] [Related]
33. Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds.
Hultman Ia; Vedin C; Abrahamsson A; Winiwarter S; Darnell M
Mol Pharm; 2016 Aug; 13(8):2796-807. PubMed ID: 27377099
[TBL] [Abstract][Full Text] [Related]
34. Synthetic cannabinoid BB-22 (QUCHIC): Human hepatocytes metabolism with liquid chromatography-high resolution mass spectrometry detection.
Carlier J; Diao X; Huestis MA
J Pharm Biomed Anal; 2018 Aug; 157():27-35. PubMed ID: 29754040
[TBL] [Abstract][Full Text] [Related]
35. Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse.
Foster JR; Jacobsen M; Kenna G; Schulz-Utermoehl T; Morikawa Y; Salmu J; Wilson ID
Toxicol Pathol; 2012 Dec; 40(8):1106-16. PubMed ID: 22673116
[TBL] [Abstract][Full Text] [Related]
36. Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans.
Nakada N; Kawamura A; Kamimura H; Sato K; Kazuki Y; Kakuni M; Ohbuchi M; Kato K; Tateno C; Oshimura M; Usui T
Biopharm Drug Dispos; 2016 Jan; 37(1):3-14. PubMed ID: 26352195
[TBL] [Abstract][Full Text] [Related]
37. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.
Aninat C; Piton A; Glaise D; Le Charpentier T; Langouët S; Morel F; Guguen-Guillouzo C; Guillouzo A
Drug Metab Dispos; 2006 Jan; 34(1):75-83. PubMed ID: 16204462
[TBL] [Abstract][Full Text] [Related]
38. Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells.
Ogasawara A; Kato N; Torimoto N; Aohara F; Ohashi R; Yamada Y; Taniguchi H
Drug Metab Lett; 2018; 12(1):14-23. PubMed ID: 29357810
[TBL] [Abstract][Full Text] [Related]
39. Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism.
Liu Y; Wei J; Lu J; Lei D; Yan S; Li X
Mater Sci Eng C Mater Biol Appl; 2016 Jun; 63():475-84. PubMed ID: 27040241
[TBL] [Abstract][Full Text] [Related]
40. The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human.
Andersson TB; Kanebratt KP; Kenna JG
Expert Opin Drug Metab Toxicol; 2012 Jul; 8(7):909-20. PubMed ID: 22568886
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]