BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 31079449)

  • 1. Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.
    Cioffi CL; Racz B; Varadi A; Freeman EE; Conlon MP; Chen P; Zhu L; Kitchen DB; Barnes KD; Martin WH; Pearson PG; Johnson G; Blaner WS; Petrukhin K
    J Med Chem; 2019 Jun; 62(11):5470-5500. PubMed ID: 31079449
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.
    Cioffi CL; Dobri N; Freeman EE; Conlon MP; Chen P; Stafford DG; Schwarz DM; Golden KC; Zhu L; Kitchen DB; Barnes KD; Racz B; Qin Q; Michelotti E; Cywin CL; Martin WH; Pearson PG; Johnson G; Petrukhin K
    J Med Chem; 2014 Sep; 57(18):7731-57. PubMed ID: 25210858
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.
    Dobri N; Qin Q; Kong J; Yamamoto K; Liu Z; Moiseyev G; Ma JX; Allikmets R; Sparrow JR; Petrukhin K
    Invest Ophthalmol Vis Sci; 2013 Jan; 54(1):85-95. PubMed ID: 23211825
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice.
    Lee SA; Yuen JJ; Jiang H; Kahn BB; Blaner WS
    Hepatology; 2016 Nov; 64(5):1534-1546. PubMed ID: 27227735
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle.
    Racz B; Varadi A; Kong J; Allikmets R; Pearson PG; Johnson G; Cioffi CL; Petrukhin K
    J Biol Chem; 2018 Jul; 293(29):11574-11588. PubMed ID: 29871924
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolic syndrome and non-alcoholic fatty liver disease in mice.
    Tan Y; Sun LQ; Kamal MA; Wang X; Seale JP; Qu X
    Biochim Biophys Acta; 2011 Dec; 1811(12):1045-53. PubMed ID: 21983273
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.
    Cioffi CL; Muthuraman P; Raja A; Varadi A; Racz B; Petrukhin K
    J Med Chem; 2020 Oct; 63(19):11054-11084. PubMed ID: 32878437
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Retinol-Binding Protein 4 Induces Hepatic Mitochondrial Dysfunction and Promotes Hepatic Steatosis.
    Liu Y; Mu D; Chen H; Li D; Song J; Zhong Y; Xia M
    J Clin Endocrinol Metab; 2016 Nov; 101(11):4338-4348. PubMed ID: 27504850
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease.
    Cioffi CL; Racz B; Freeman EE; Conlon MP; Chen P; Stafford DG; Schwarz DM; Zhu L; Kitchen DB; Barnes KD; Dobri N; Michelotti E; Cywin CL; Martin WH; Pearson PG; Johnson G; Petrukhin K
    J Med Chem; 2015 Aug; 58(15):5863-88. PubMed ID: 26181715
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1.
    Petta S; Cammà C; Di Marco V; Alessi N; Barbaria F; Cabibi D; Caldarella R; Ciminnisi S; Licata A; Massenti MF; Mazzola A; Tarantino G; Marchesini G; Craxì A
    Hepatology; 2008 Jul; 48(1):28-37. PubMed ID: 18506842
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Retinol binding protein 4 antagonists and protein synthesis inhibitors: Potential for therapeutic development.
    Kim N; Priefer R
    Eur J Med Chem; 2021 Dec; 226():113856. PubMed ID: 34547506
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease.
    Alkhouri N; Lopez R; Berk M; Feldstein AE
    J Clin Gastroenterol; 2009; 43(10):985-9. PubMed ID: 19525859
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus.
    Wu H; Jia W; Bao Y; Lu J; Zhu J; Wang R; Chen Y; Xiang K
    Diabetes Res Clin Pract; 2008 Feb; 79(2):185-90. PubMed ID: 17904683
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease.
    Nobili V; Alkhouri N; Alisi A; Ottino S; Lopez R; Manco M; Feldstein AE
    Clin Gastroenterol Hepatol; 2009 May; 7(5):575-9. PubMed ID: 19268270
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.
    Yang Q; Graham TE; Mody N; Preitner F; Peroni OD; Zabolotny JM; Kotani K; Quadro L; Kahn BB
    Nature; 2005 Jul; 436(7049):356-62. PubMed ID: 16034410
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amyloid deposition in a mouse model humanized at the transthyretin and retinol-binding protein 4 loci.
    Li X; Lyu Y; Shen J; Mu Y; Qiang L; Liu L; Araki K; Imbimbo BP; Yamamura KI; Jin S; Li Z
    Lab Invest; 2018 Apr; 98(4):512-524. PubMed ID: 29330472
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Serum retinol-binding protein 4 is independently associated with pediatric NAFLD and fasting triglyceride level.
    Huang SC; Yang YJ
    J Pediatr Gastroenterol Nutr; 2013 Feb; 56(2):145-50. PubMed ID: 22983378
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration.
    Du M; Phelps E; Balangue MJ; Dockins A; Moiseyev G; Shin Y; Kane S; Otalora L; Ma JX; Farjo R; Farjo KM
    Invest Ophthalmol Vis Sci; 2017 Aug; 58(10):4375–4383. PubMed ID: 28813718
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rescue of retinal morphology and function in a humanized mouse at the mouse retinol-binding protein locus.
    Liu L; Suzuki T; Shen J; Wakana S; Araki K; Yamamura KI; Lei L; Li Z
    Lab Invest; 2017 Apr; 97(4):395-408. PubMed ID: 28134916
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter.
    Chang ML; Chen WT; Hu JH; Chen SC; Gu PW; Chien RN
    Virulence; 2020 Dec; 11(1):1501-1511. PubMed ID: 33135589
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.