BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 31085544)

  • 1. Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.
    Zhang D; Fourie-O'Donohue A; Dragovich PS; Pillow TH; Sadowsky JD; Kozak KR; Cass RT; Liu L; Deng Y; Liu Y; Hop CECA; Khojasteh SC
    Drug Metab Dispos; 2019 Oct; 47(10):1156-1163. PubMed ID: 31085544
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
    Pei Z; Chen C; Chen J; Cruz-Chuh JD; Delarosa R; Deng Y; Fourie-O'Donohue A; Figueroa I; Guo J; Jin W; Khojasteh SC; Kozak KR; Latifi B; Lee J; Li G; Lin E; Liu L; Lu J; Martin S; Ng C; Nguyen T; Ohri R; Lewis Phillips G; Pillow TH; Rowntree RK; Stagg NJ; Stokoe D; Ulufatu S; Verma VA; Wai J; Wang J; Xu K; Xu Z; Yao H; Yu SF; Zhang D; Dragovich PS
    Mol Pharm; 2018 Sep; 15(9):3979-3996. PubMed ID: 30040421
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers.
    Pillow TH; Schutten M; Yu SF; Ohri R; Sadowsky J; Poon KA; Solis W; Zhong F; Del Rosario G; Go MAT; Lau J; Yee S; He J; Liu L; Ng C; Xu K; Leipold DD; Kamath AV; Zhang D; Masterson L; Gregson SJ; Howard PW; Fang F; Chen J; Gunzner-Toste J; Kozak KK; Spencer S; Polakis P; Polson AG; Flygare JA; Junutula JR
    Mol Cancer Ther; 2017 May; 16(5):871-878. PubMed ID: 28223423
    [TBL] [Abstract][Full Text] [Related]  

  • 4. S-glutathiolated hepatocyte proteins and insulin disulfides as substrates for reduction by glutaredoxin, thioredoxin, protein disulfide isomerase, and glutathione.
    Jung CH; Thomas JA
    Arch Biochem Biophys; 1996 Nov; 335(1):61-72. PubMed ID: 8914835
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural and mechanistic aspects of S-S bonds in the thioredoxin-like family of proteins.
    Sousa SF; Neves RPP; Waheed SO; Fernandes PA; Ramos MJ
    Biol Chem; 2019 Apr; 400(5):575-587. PubMed ID: 30367780
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selenium and the thioredoxin and glutaredoxin systems.
    Björnstedt M; Kumar S; Björkhem L; Spyrou G; Holmgren A
    Biomed Environ Sci; 1997 Sep; 10(2-3):271-9. PubMed ID: 9315320
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Thioredoxin h isoforms from rice are differentially reduced by NADPH/thioredoxin or GSH/glutaredoxin systems.
    Shaykholeslam Esfahani E; Shahpiri A
    Int J Biol Macromol; 2015 Mar; 74():243-8. PubMed ID: 25541357
    [TBL] [Abstract][Full Text] [Related]  

  • 8. One cysteine is enough: A monothiol Grx can functionally replace all cytosolic Trx and dithiol Grx.
    Zimmermann J; Oestreicher J; Hess S; Herrmann JM; Deponte M; Morgan B
    Redox Biol; 2020 Sep; 36():101598. PubMed ID: 32521506
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conferring specificity in redox pathways by enzymatic thiol/disulfide exchange reactions.
    Netto LE; de Oliveira MA; Tairum CA; da Silva Neto JF
    Free Radic Res; 2016; 50(2):206-45. PubMed ID: 26573728
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of Disulfide Bond Rebridged Fab-Drug Conjugates Prepared Using a Dual Maleimide Pyrrolobenzodiazepine Cytotoxic Payload.
    Ruddle BT; Fleming R; Wu H; Gao C; Dimasi N
    ChemMedChem; 2019 Jun; 14(12):1185-1195. PubMed ID: 30980702
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.
    Zhang D; Pillow TH; Ma Y; Cruz-Chuh JD; Kozak KR; Sadowsky JD; Lewis Phillips GD; Guo J; Darwish M; Fan P; Chen J; He C; Wang T; Yao H; Xu Z; Chen J; Wai J; Pei Z; Hop CE; Khojasteh SC; Dragovich PS
    ACS Med Chem Lett; 2016 Nov; 7(11):988-993. PubMed ID: 27882196
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human IgG is substrate for the thioredoxin system: differential cleavage pattern of interchain disulfide bridges in IgG subclasses.
    Magnusson CG; Björnstedt M; Holmgren A
    Mol Immunol; 1997 Jul; 34(10):709-17. PubMed ID: 9430198
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evidence for a subgroup of thioredoxin h that requires GSH/Grx for its reduction.
    Gelhaye E; Rouhier N; Jacquot JP
    FEBS Lett; 2003 Dec; 555(3):443-8. PubMed ID: 14675753
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Two resident ER-proteins, CaBP1 and CaBP2, with thioredoxin domains, are substrates for thioredoxin reductase: comparison with protein disulfide isomerase.
    Lundström-Ljung J; Birnbach U; Rupp K; Söling HD; Holmgren A
    FEBS Lett; 1995 Jan; 357(3):305-8. PubMed ID: 7835433
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes.
    Ukuwela AA; Bush AI; Wedd AG; Xiao Z
    Biochem J; 2017 Nov; 474(22):3799-3815. PubMed ID: 28963348
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The thioredoxin antioxidant system.
    Lu J; Holmgren A
    Free Radic Biol Med; 2014 Jan; 66():75-87. PubMed ID: 23899494
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex.
    Arnér ES; Nakamura H; Sasada T; Yodoi J; Holmgren A; Spyrou G
    Free Radic Biol Med; 2001 Nov; 31(10):1170-8. PubMed ID: 11705695
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Disulfide bond formation in the Escherichia coli cytoplasm: an in vivo role reversal for the thioredoxins.
    Stewart EJ; Aslund F; Beckwith J
    EMBO J; 1998 Oct; 17(19):5543-50. PubMed ID: 9755155
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 17beta-estradiol induces protein thiol/disulfide oxidoreductases and protects cultured bovine aortic endothelial cells from oxidative stress.
    Ejima K; Nanri H; Araki M; Uchida K; Kashimura M; Ikeda M
    Eur J Endocrinol; 1999 Jun; 140(6):608-13. PubMed ID: 10366417
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Thioredoxin Cross-Linking by Nitrogen Mustard in Lung Epithelial Cells: Formation of Multimeric Thioredoxin/Thioredoxin Reductase Complexes and Inhibition of Disulfide Reduction.
    Jan YH; Heck DE; Casillas RP; Laskin DL; Laskin JD
    Chem Res Toxicol; 2015 Nov; 28(11):2091-103. PubMed ID: 26451472
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.