146 related articles for article (PubMed ID: 31091068)
1. Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux.
Komulainen E; Pennicott L; Le Grand D; Caldecott KW
ACS Chem Biol; 2019 Jun; 14(6):1110-1114. PubMed ID: 31091068
[TBL] [Abstract][Full Text] [Related]
2. Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide.
Kankanala J; Ribeiro CJA; Kiselev E; Ravji A; Williams J; Xie J; Aihara H; Pommier Y; Wang Z
J Med Chem; 2019 May; 62(9):4669-4682. PubMed ID: 30998359
[TBL] [Abstract][Full Text] [Related]
3. Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
Kiselev E; Ravji A; Kankanala J; Xie J; Wang Z; Pommier Y
DNA Repair (Amst); 2020 Jan; 85():102747. PubMed ID: 31775111
[TBL] [Abstract][Full Text] [Related]
4. Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.
Kont YS; Dutta A; Mallisetty A; Mathew J; Minas T; Kraus C; Dhopeshwarkar P; Kallakury B; Mitra S; Üren A; Adhikari S
DNA Repair (Amst); 2016 Jul; 43():38-47. PubMed ID: 27235629
[TBL] [Abstract][Full Text] [Related]
5. Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.
Marchand C; Abdelmalak M; Kankanala J; Huang SY; Kiselev E; Fesen K; Kurahashi K; Sasanuma H; Takeda S; Aihara H; Wang Z; Pommier Y
ACS Chem Biol; 2016 Jul; 11(7):1925-33. PubMed ID: 27128689
[TBL] [Abstract][Full Text] [Related]
6. Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms.
Tsuda M; Kitamasu K; Hosokawa S; Nakano T; Ide H
Nucleosides Nucleotides Nucleic Acids; 2020; 39(1-3):170-184. PubMed ID: 31608820
[TBL] [Abstract][Full Text] [Related]
7. Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway.
Park JM; Zhang H; Nie L; Wang C; Huang M; Feng X; Tang M; Chen Z; Xiong Y; Lee N; Li S; Yin L; Hart T; Chen J
Int J Mol Sci; 2023 Mar; 24(7):. PubMed ID: 37047518
[TBL] [Abstract][Full Text] [Related]
8. Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes.
Lee KC; Swan RL; Sondka Z; Padget K; Cowell IG; Austin CA
Int J Mol Sci; 2018 Jul; 19(7):. PubMed ID: 30011940
[TBL] [Abstract][Full Text] [Related]
9. Cancer sensitizing effect of deazaflavin analogs is associated with increased intracellular drug accumulation.
Belhadj Z; Offei S; Jacobson BA; Cambron D; Kratzke RA; Wang Z; Xie J
Eur J Pharm Sci; 2024 Feb; 193():106686. PubMed ID: 38159687
[TBL] [Abstract][Full Text] [Related]
10. Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).
Gao R; Schellenberg MJ; Huang SY; Abdelmalak M; Marchand C; Nitiss KC; Nitiss JL; Williams RS; Pommier Y
J Biol Chem; 2014 Jun; 289(26):17960-9. PubMed ID: 24808172
[TBL] [Abstract][Full Text] [Related]
11. TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
Zeng Z; Cortés-Ledesma F; El Khamisy SF; Caldecott KW
J Biol Chem; 2011 Jan; 286(1):403-9. PubMed ID: 21030584
[TBL] [Abstract][Full Text] [Related]
12. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
Gómez-Herreros F; Romero-Granados R; Zeng Z; Alvarez-Quilón A; Quintero C; Ju L; Umans L; Vermeire L; Huylebroeck D; Caldecott KW; Cortés-Ledesma F
PLoS Genet; 2013; 9(3):e1003226. PubMed ID: 23505375
[TBL] [Abstract][Full Text] [Related]
13. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
Zeng Z; Sharma A; Ju L; Murai J; Umans L; Vermeire L; Pommier Y; Takeda S; Huylebroeck D; Caldecott KW; El-Khamisy SF
Nucleic Acids Res; 2012 Sep; 40(17):8371-80. PubMed ID: 22740648
[TBL] [Abstract][Full Text] [Related]
14. Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities.
Zhang Y; Yang H; Wang FT; Peng X; Liu HY; Li QJ; An LK
Eur J Med Chem; 2022 Aug; 238():114445. PubMed ID: 35580424
[TBL] [Abstract][Full Text] [Related]
15. Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia.
Zagnoli-Vieira G; Brazina J; Van Den Bogaert K; Huybrechts W; Molenaers G; Caldecott KW; Van Esch H
Hum Genet; 2023 Sep; 142(9):1417-1427. PubMed ID: 37558815
[TBL] [Abstract][Full Text] [Related]
16. Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Hornyak P; Askwith T; Walker S; Komulainen E; Paradowski M; Pennicott LE; Bartlett EJ; Brissett NC; Raoof A; Watson M; Jordan AM; Ogilvie DJ; Ward SE; Atack JR; Pearl LH; Caldecott KW; Oliver AW
Biochem J; 2016 Jul; 473(13):1869-79. PubMed ID: 27099339
[TBL] [Abstract][Full Text] [Related]
17. Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Schellenberg MJ; Perera L; Strom CN; Waters CA; Monian B; Appel CD; Vilas CK; Williams JG; Ramsden DA; Williams RS
Nucleic Acids Res; 2016 May; 44(8):3829-44. PubMed ID: 27060144
[TBL] [Abstract][Full Text] [Related]
18. Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.
Rao T; Gao R; Takada S; Al Abo M; Chen X; Walters KJ; Pommier Y; Aihara H
Nucleic Acids Res; 2016 Dec; 44(21):10201-10215. PubMed ID: 27543075
[TBL] [Abstract][Full Text] [Related]
19. Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.
Raoof A; Depledge P; Hamilton NM; Hamilton NS; Hitchin JR; Hopkins GV; Jordan AM; Maguire LA; McGonagle AE; Mould DP; Rushbrooke M; Small HF; Smith KM; Thomson GJ; Turlais F; Waddell ID; Waszkowycz B; Watson AJ; Ogilvie DJ
J Med Chem; 2013 Aug; 56(16):6352-70. PubMed ID: 23859074
[TBL] [Abstract][Full Text] [Related]
20. FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.
Kametani Y; Takahata C; Narita T; Tanaka K; Iwai S; Kuraoka I
Carcinogenesis; 2016 Jan; 37(1):56-62. PubMed ID: 26581212
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
