BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 31091068)

  • 21. New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).
    Ribeiro CJA; Kankanala J; Shi K; Kurahashi K; Kiselev E; Ravji A; Pommier Y; Aihara H; Wang Z
    Eur J Pharm Sci; 2018 Jun; 118():67-79. PubMed ID: 29574079
    [TBL] [Abstract][Full Text] [Related]  

  • 22. TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.
    Al Mahmud MR; Ishii K; Bernal-Lozano C; Delgado-Sainz I; Toi M; Akamatsu S; Fukumoto M; Watanabe M; Takeda S; Cortés-Ledesma F; Sasanuma H
    Genes Cells; 2020 Jul; 25(7):450-465. PubMed ID: 32277721
    [TBL] [Abstract][Full Text] [Related]  

  • 23. MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner.
    Shu J; Jiang J; Wang X; Yang X; Zhao G; Cai T
    Cell Death Dis; 2024 Jan; 15(1):83. PubMed ID: 38263255
    [TBL] [Abstract][Full Text] [Related]  

  • 24. 4-Benzylideneisoquinoline-1,3(
    Senaweera S; He T; Cui H; Aihara H; Wang Z
    Med Chem Res; 2021 Feb; 30(2):371-386. PubMed ID: 33776385
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).
    Kankanala J; Marchand C; Abdelmalak M; Aihara H; Pommier Y; Wang Z
    J Med Chem; 2016 Mar; 59(6):2734-46. PubMed ID: 26910725
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations.
    Atwal M; Swan RL; Rowe C; Lee KC; Lee DC; Armstrong L; Cowell IG; Austin CA
    Mol Pharmacol; 2019 Oct; 96(4):475-484. PubMed ID: 31399497
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase.
    Thomson G; Watson A; Caldecott K; Denneny O; Depledge P; Hamilton N; Hopkins G; Jordan A; Morrow C; Raoof A; Waddell I; Ogilvie D
    Anal Biochem; 2013 May; 436(2):145-50. PubMed ID: 23416181
    [TBL] [Abstract][Full Text] [Related]  

  • 28. ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.
    Bian K; Muppani NR; Elkhadragy L; Wang W; Zhang C; Chen T; Jung S; Seternes OM; Long W
    Oncotarget; 2016 Feb; 7(6):6665-75. PubMed ID: 26701725
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA.
    Morimoto S; Tsuda M; Bunch H; Sasanuma H; Austin C; Takeda S
    Genes (Basel); 2019 Oct; 10(11):. PubMed ID: 31671674
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding.
    Shimizu N; Hamada Y; Morozumi R; Yamamoto J; Iwai S; Sugiyama KI; Ide H; Tsuda M
    J Biol Chem; 2023 Aug; 299(8):104988. PubMed ID: 37392847
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks.
    Akter S; Shimba A; Ikuta K; Mahmud MRA; Yamada S; Sasanuma H; Tsuda M; Sone M; Ago Y; Murai K; Tanaka H; Takeda S
    Genes Cells; 2023 Jan; 28(1):53-67. PubMed ID: 36415926
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.
    Canela A; Maman Y; Huang SN; Wutz G; Tang W; Zagnoli-Vieira G; Callen E; Wong N; Day A; Peters JM; Caldecott KW; Pommier Y; Nussenzweig A
    Mol Cell; 2019 Jul; 75(2):252-266.e8. PubMed ID: 31202577
    [TBL] [Abstract][Full Text] [Related]  

  • 33. RAD54L2 counters TOP2-DNA adducts to promote genome stability.
    D'Alessandro G; Morales-Juarez DA; Richards SL; Nitiss KC; Serrano-Benitez A; Wang J; Thomas JC; Gupta V; Voigt A; Belotserkovskaya R; Goh CG; Bowden AR; Galanty Y; Beli P; Nitiss JL; Zagnoli-Vieira G; Jackson SP
    Sci Adv; 2023 Dec; 9(49):eadl2108. PubMed ID: 38055822
    [TBL] [Abstract][Full Text] [Related]  

  • 34. TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
    Gómez-Herreros F; Zagnoli-Vieira G; Ntai I; Martínez-Macías MI; Anderson RM; Herrero-Ruíz A; Caldecott KW
    Nat Commun; 2017 Aug; 8(1):233. PubMed ID: 28794467
    [TBL] [Abstract][Full Text] [Related]  

  • 35. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
    Gómez-Herreros F; Schuurs-Hoeijmakers JH; McCormack M; Greally MT; Rulten S; Romero-Granados R; Counihan TJ; Chaila E; Conroy J; Ennis S; Delanty N; Cortés-Ledesma F; de Brouwer AP; Cavalleri GL; El-Khamisy SF; de Vries BB; Caldecott KW
    Nat Genet; 2014 May; 46(5):516-21. PubMed ID: 24658003
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2).
    Yu LM; Hu Z; Chen Y; Ravji A; Lopez S; Plescia CB; Yu Q; Yang H; Abdelmalak M; Saha S; Agama K; Kiselev E; Marchand C; Pommier Y; An LK
    Eur J Med Chem; 2018 May; 151():777-796. PubMed ID: 29677635
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules.
    Mariani A; Bartoli A; Atwal M; Lee KC; Austin CA; Rodriguez R
    J Med Chem; 2015 Jun; 58(11):4851-6. PubMed ID: 25945730
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.
    Schellenberg MJ; Appel CD; Riccio AA; Butler LR; Krahn JM; Liebermann JA; Cortés-Ledesma F; Williams RS
    Nucleic Acids Res; 2020 Jun; 48(11):6310-6325. PubMed ID: 32356875
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.
    Hoa NN; Shimizu T; Zhou ZW; Wang ZQ; Deshpande RA; Paull TT; Akter S; Tsuda M; Furuta R; Tsutsui K; Takeda S; Sasanuma H
    Mol Cell; 2016 Nov; 64(3):580-592. PubMed ID: 27814490
    [TBL] [Abstract][Full Text] [Related]  

  • 40. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
    Schellenberg MJ; Lieberman JA; Herrero-Ruiz A; Butler LR; Williams JG; Muñoz-Cabello AM; Mueller GA; London RE; Cortés-Ledesma F; Williams RS
    Science; 2017 Sep; 357(6358):1412-1416. PubMed ID: 28912134
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.