BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 31112178)

  • 1. Ixocarpalactone A from dietary tomatillo inhibits pancreatic cancer growth by targeting PHGDH.
    Zheng M; Guo J; Xu J; Yang K; Tang R; Gu X; Li H; Chen L
    Food Funct; 2019 Jun; 10(6):3386-3395. PubMed ID: 31112178
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
    Guo J; Gu X; Zheng M; Zhang Y; Chen L; Li H
    Bioorg Chem; 2019 Jun; 87():16-22. PubMed ID: 30852233
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
    Mullarky E; Xu J; Robin AD; Huggins DJ; Jennings A; Noguchi N; Olland A; Lakshminarasimhan D; Miller M; Tomita D; Michino M; Su T; Zhang G; Stamford AW; Meinke PT; Kargman S; Cantley LC
    Bioorg Med Chem Lett; 2019 Sep; 29(17):2503-2510. PubMed ID: 31327531
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
    Ma X; Li B; Liu J; Fu Y; Luo Y
    J Exp Clin Cancer Res; 2019 Feb; 38(1):66. PubMed ID: 30744688
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chemical Components of the Fruits of
    Wang Y; Zheng M; Jiang Q; Xu Y; Zhou X; Zhang N; Sun D; Li H; Chen L
    J Agric Food Chem; 2021 Oct; 69(42):12433-12444. PubMed ID: 34664962
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.
    Wang Q; Liberti MV; Liu P; Deng X; Liu Y; Locasale JW; Lai L
    Cell Chem Biol; 2017 Jan; 24(1):55-65. PubMed ID: 28042046
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
    Yang Y; Xiang K; Sun D; Zheng M; Song Z; Li M; Wang X; Li H; Chen L
    Bioorg Med Chem; 2021 Apr; 36():116095. PubMed ID: 33735687
    [TBL] [Abstract][Full Text] [Related]  

  • 8. PHGDH is an independent prognosis marker and contributes cell proliferation, migration and invasion in human pancreatic cancer.
    Song Z; Feng C; Lu Y; Lin Y; Dong C
    Gene; 2018 Feb; 642():43-50. PubMed ID: 29128633
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer.
    Zhao X; Fu J; Du J; Xu W
    Int J Biol Sci; 2020; 16(9):1495-1506. PubMed ID: 32226297
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
    Pacold ME; Brimacombe KR; Chan SH; Rohde JM; Lewis CA; Swier LJ; Possemato R; Chen WW; Sullivan LB; Fiske BP; Cho S; Freinkman E; Birsoy K; Abu-Remaileh M; Shaul YD; Liu CM; Zhou M; Koh MJ; Chung H; Davidson SM; Luengo A; Wang AQ; Xu X; Yasgar A; Liu L; Rai G; Westover KD; Vander Heiden MG; Shen M; Gray NS; Boxer MB; Sabatini DM
    Nat Chem Biol; 2016 Jun; 12(6):452-8. PubMed ID: 27110680
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
    Mullarky E; Lucki NC; Beheshti Zavareh R; Anglin JL; Gomes AP; Nicolay BN; Wong JC; Christen S; Takahashi H; Singh PK; Blenis J; Warren JD; Fendt SM; Asara JM; DeNicola GM; Lyssiotis CA; Lairson LL; Cantley LC
    Proc Natl Acad Sci U S A; 2016 Feb; 113(7):1778-83. PubMed ID: 26831078
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3.
    Jing Z; Heng W; Xia L; Ning W; Yafei Q; Yao Z; Shulan Z
    Cancer Biol Ther; 2015; 16(4):541-8. PubMed ID: 25719555
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer.
    Itoyama R; Yasuda-Yoshihara N; Kitamura F; Yasuda T; Bu L; Yonemura A; Uchihara T; Arima K; Hu X; Jun Z; Okamoto Y; Akiyama T; Yamashita K; Nakao Y; Yusa T; Kitano Y; Higashi T; Miyata T; Imai K; Hayashi H; Yamashita YI; Mikawa T; Kondoh H; Baba H; Ishimoto T
    Cancer Lett; 2021 Dec; 523():29-42. PubMed ID: 34508795
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
    Rohde JM; Brimacombe KR; Liu L; Pacold ME; Yasgar A; Cheff DM; Lee TD; Rai G; Baljinnyam B; Li Z; Simeonov A; Hall MD; Shen M; Sabatini DM; Boxer MB
    Bioorg Med Chem; 2018 May; 26(8):1727-1739. PubMed ID: 29555419
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
    Possemato R; Marks KM; Shaul YD; Pacold ME; Kim D; Birsoy K; Sethumadhavan S; Woo HK; Jang HG; Jha AK; Chen WW; Barrett FG; Stransky N; Tsun ZY; Cowley GS; Barretina J; Kalaany NY; Hsu PP; Ottina K; Chan AM; Yuan B; Garraway LA; Root DE; Mino-Kenudson M; Brachtel EF; Driggers EM; Sabatini DM
    Nature; 2011 Aug; 476(7360):346-50. PubMed ID: 21760589
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism.
    Zhao JY; Feng KR; Wang F; Zhang JW; Cheng JF; Lin GQ; Gao D; Tian P
    Eur J Med Chem; 2021 May; 217():113379. PubMed ID: 33756126
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy.
    Zhou X; Tan Y; Gou K; Tao L; Luo Y; Zhou Y; Zuo Z; Sun Q; Luo Y; Zhao Y
    Bioorg Chem; 2021 Oct; 115():105159. PubMed ID: 34298241
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation.
    Yoshino H; Enokida H; Osako Y; Nohata N; Yonemori M; Sugita S; Kuroshima K; Tsuruda M; Tatarano S; Nakagawa M
    Mol Oncol; 2020 Sep; 14(9):2190-2202. PubMed ID: 32386122
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment.
    Li M; Wu C; Yang Y; Zheng M; Yu S; Wang J; Chen L; Li H
    Cell Oncol (Dordr); 2021 Jun; 44(3):541-556. PubMed ID: 33735398
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.
    Liu J; Zhang C; Wu H; Sun XX; Li Y; Huang S; Yue X; Lu SE; Shen Z; Su X; White E; Haffty BG; Hu W; Feng Z
    J Clin Invest; 2020 Jun; 130(6):3253-3269. PubMed ID: 32478681
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.