BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 31117515)

  • 1. Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
    Guo Z; Zhang Z; Yang H; Cao D; Xu X; Zheng X; Chen D; Wang Q; Li Y; Li J; Du Z; Wang X; Chen L; Ding J; Shen J; Geng M; Huang X; Xiong B
    J Med Chem; 2019 Jun; 62(11):5414-5433. PubMed ID: 31117515
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors.
    Zhu K; Song JL; Tao HR; Cheng ZQ; Jiang CS; Zhang H
    Bioorg Med Chem Lett; 2018 Dec; 28(23-24):3693-3699. PubMed ID: 30366617
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.
    Shen Y; Szewczyk MM; Eram MS; Smil D; Kaniskan HÜ; de Freitas RF; Senisterra G; Li F; Schapira M; Brown PJ; Arrowsmith CH; Barsyte-Lovejoy D; Liu J; Vedadi M; Jin J
    J Med Chem; 2016 Oct; 59(19):9124-9139. PubMed ID: 27584694
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.
    Sutherland M; Li A; Kaghad A; Panagopoulos D; Li F; Szewczyk M; Smil D; Scholten C; Bouché L; Stellfeld T; Arrowsmith CH; Barsyte D; Vedadi M; Hartung IV; Steuber H; Britton R; Santhakumar V
    ChemMedChem; 2021 Apr; 16(7):1116-1125. PubMed ID: 33513288
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays.
    Ye F; Zhang W; Ye X; Jin J; Lv Z; Luo C
    J Chem Inf Model; 2018 May; 58(5):1066-1073. PubMed ID: 29672052
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity.
    Zhu K; Shao J; Tao H; Yan X; Luo C; Zhang H; Duan W
    J Comput Aided Mol Des; 2019 Aug; 33(8):775-785. PubMed ID: 31312965
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening.
    Ye Y; Zhang B; Mao R; Zhang C; Wang Y; Xing J; Liu YC; Luo X; Ding H; Yang Y; Zhou B; Jiang H; Chen K; Luo C; Zheng M
    Org Biomol Chem; 2017 May; 15(17):3648-3661. PubMed ID: 28397890
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).
    Huynh T; Chen Z; Pang S; Geng J; Bandiera T; Bindi S; Vianello P; Roletto F; Thieffine S; Galvani A; Vaccaro W; Poss MA; Trainor GL; Lorenzi MV; Gottardis M; Jayaraman L; Purandare AV
    Bioorg Med Chem Lett; 2009 Jun; 19(11):2924-7. PubMed ID: 19419866
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations.
    Zhu K; Jiang C; Tao H; Liu J; Zhang H; Luo C
    Bioorg Med Chem Lett; 2018 May; 28(9):1476-1483. PubMed ID: 29628326
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
    Cura V; Marechal N; Troffer-Charlier N; Strub JM; van Haren MJ; Martin NI; Cianférani S; Bonnefond L; Cavarelli J
    FEBS J; 2017 Jan; 284(1):77-96. PubMed ID: 27879050
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.
    Shao J; Zhu K; Du D; Zhang Y; Tao H; Chen Z; Jiang H; Chen K; Luo C; Duan W
    Eur J Med Chem; 2019 Feb; 164():317-333. PubMed ID: 30605830
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma.
    Liu Z; Lin M; Liu C; Chen X; Chen Q; Li X; Wu X; Wang Y; Wang L; Yang F; Luo C; Jin J; Ye F
    J Med Chem; 2024 Apr; 67(8):6313-6326. PubMed ID: 38574345
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes.
    Iyamu ID; Al-Hamashi AA; Huang R
    Biomolecules; 2021 Jun; 11(6):. PubMed ID: 34201091
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.
    Wang C; Jiang H; Jin J; Xie Y; Chen Z; Zhang H; Lian F; Liu YC; Zhang C; Ding H; Chen S; Zhang N; Zhang Y; Jiang H; Chen K; Ye F; Yao Z; Luo C
    J Med Chem; 2017 Nov; 60(21):8888-8905. PubMed ID: 29019697
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
    Chan-Penebre E; Kuplast KG; Majer CR; Boriack-Sjodin PA; Wigle TJ; Johnston LD; Rioux N; Munchhof MJ; Jin L; Jacques SL; West KA; Lingaraj T; Stickland K; Ribich SA; Raimondi A; Scott MP; Waters NJ; Pollock RM; Smith JJ; Barbash O; Pappalardi M; Ho TF; Nurse K; Oza KP; Gallagher KT; Kruger R; Moyer MP; Copeland RA; Chesworth R; Duncan KW
    Nat Chem Biol; 2015 Jun; 11(6):432-7. PubMed ID: 25915199
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5.
    Rong D; Zhou K; Fang W; Yang H; Zhang Y; Shi Q; Huang Y; Li J; Dong H; Li L; Ding J; Huang X; Wang Y
    J Med Chem; 2022 Jun; 65(11):7854-7875. PubMed ID: 35612488
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1).
    Xie Y; Zhou R; Lian F; Liu Y; Chen L; Shi Z; Zhang N; Zheng M; Shen B; Jiang H; Liang Z; Luo C
    Org Biomol Chem; 2014 Dec; 12(47):9665-73. PubMed ID: 25348815
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1).
    Therrien E; Larouche G; Manku S; Allan M; Nguyen N; Styhler S; Robert MF; Goulet AC; Besterman JM; Nguyen H; Wahhab A
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6725-32. PubMed ID: 19836951
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor: Design, synthesis and biological evaluation.
    Yang C; Xu C; Li Z; Chen Y; Wu T; Hong H; Lu M; Jia Y; Yang Y; Liu X; Deng M; Chen Z; Li Q; Ling Y; Zhou Y
    Eur J Med Chem; 2021 Nov; 223():113661. PubMed ID: 34237636
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies.
    Wan H; Huynh T; Pang S; Geng J; Vaccaro W; Poss MA; Trainor GL; Lorenzi MV; Gottardis M; Jayaraman L; Purandare AV
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5063-6. PubMed ID: 19632837
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.