118 related articles for article (PubMed ID: 31122869)
1. Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.
Bischoff FP; Velter AI; Minne G; Pieters S; Berthelot D; De Cleyn M; Gijsen HJM; Macdonald G; Surkyn M; Van Brandt S; Van Roosbroeck Y; Zavattaro C; Mercken M; Austin N; Dhuyvetter D; Borghys H; Ahmad I; Samanta SK
Bioorg Med Chem Lett; 2019 Jul; 29(14):1737-1745. PubMed ID: 31122869
[TBL] [Abstract][Full Text] [Related]
2. Anilinotriazoles as potent gamma secretase modulators.
Velter AI; Bischoff FP; Berthelot D; De Cleyn M; Oehlrich D; Jaroskova L; Macdonald G; Minne G; Pieters S; Rombouts F; Van Brandt S; Van Roosbroeck Y; Surkyn M; Trabanco AA; Tresadern G; Wu T; Borghys H; Mercken M; Masungi C; Gijsen H
Bioorg Med Chem Lett; 2014 Dec; 24(24):5805-5813. PubMed ID: 25454273
[TBL] [Abstract][Full Text] [Related]
3. Design and synthesis of an aminopiperidine series of γ-secretase modulators.
Kobayashi T; Iwama S; Fusano A; Kato Y; Ikeda A; Teranishi Y; Nishihara A; Tobe M
Bioorg Med Chem Lett; 2014 Jan; 24(1):378-81. PubMed ID: 24269163
[TBL] [Abstract][Full Text] [Related]
4. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators.
Gerlach K; Hobson S; Eickmeier C; Groß U; Braun C; Sieger P; Garneau M; Hoerer S; Heine N
Bioorg Med Chem; 2018 Jul; 26(12):3227-3241. PubMed ID: 29735425
[TBL] [Abstract][Full Text] [Related]
5. Design and optimization of tricyclic gamma-secretase modulators.
Shi J; Zuev D; Xu L; Lentz KA; Grace JE; Toyn JH; Olson RE; Macor JE; Thompson LA
Bioorg Med Chem Lett; 2016 Mar; 26(5):1498-502. PubMed ID: 26848108
[TBL] [Abstract][Full Text] [Related]
6. Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Pettersson M; Johnson DS; Humphrey JM; Am Ende CW; Evrard E; Efremov I; Kauffman GW; Stepan AF; Stiff CM; Xie L; Bales KR; Hajos-Korcsok E; Murrey HE; Pustilnik LR; Steyn SJ; Wood KM; Verhoest PR
Bioorg Med Chem Lett; 2015 Feb; 25(4):908-13. PubMed ID: 25582600
[TBL] [Abstract][Full Text] [Related]
7. Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
Zettl H; Ness J; Hähnke V; Beher D; Jumpertz T; Saric A; Baumann K; Pietrzik CU; Bulic B; Schneider G; Weggen S
ACS Chem Biol; 2012 Sep; 7(9):1488-95. PubMed ID: 22725102
[TBL] [Abstract][Full Text] [Related]
8. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.
Takai T; Hoashi Y; Tomata Y; Morimoto S; Nakamura M; Watanabe T; Igari T; Koike T
Bioorg Med Chem Lett; 2015 Oct; 25(19):4245-9. PubMed ID: 26298496
[TBL] [Abstract][Full Text] [Related]
9. Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators.
Bischoff F; Berthelot D; De Cleyn M; Macdonald G; Minne G; Oehlrich D; Pieters S; Surkyn M; Trabanco AA; Tresadern G; Van Brandt S; Velter I; Zaja M; Borghys H; Masungi C; Mercken M; Gijsen HJ
J Med Chem; 2012 Nov; 55(21):9089-106. PubMed ID: 22650177
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aβ₄₂ production.
Takai T; Koike T; Honda E; Kajita Y; Nakamura M; Morimoto S; Hoashi Y; Kamata M; Watanabe T; Igari T; Terauchi J
Bioorg Med Chem; 2015 May; 23(9):1923-34. PubMed ID: 25842363
[TBL] [Abstract][Full Text] [Related]
11. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
Hahn S; Brüning T; Ness J; Czirr E; Baches S; Gijsen H; Korth C; Pietrzik CU; Bulic B; Weggen S
J Neurochem; 2011 Feb; 116(3):385-95. PubMed ID: 21091478
[TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.
Rynearson KD; Buckle RN; Barnes KD; Herr RJ; Mayhew NJ; Paquette WD; Sakwa SA; Nguyen PD; Johnson G; Tanzi RE; Wagner SL
Bioorg Med Chem Lett; 2016 Aug; 26(16):3928-37. PubMed ID: 27426299
[TBL] [Abstract][Full Text] [Related]
13. Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.
Oehlrich D; Rombouts FJ; Berthelot D; Bischoff FP; De Cleyn MA; Jaroskova L; Macdonald G; Mercken M; Surkyn M; Trabanco AA; Tresadern G; Van Brandt S; Velter AI; Wu T; Gijsen HJ
Bioorg Med Chem Lett; 2013 Sep; 23(17):4794-800. PubMed ID: 23890837
[TBL] [Abstract][Full Text] [Related]
14. Novel γ-secretase modulators: a review of patents from 2008 to 2010.
Pettersson M; Kauffman GW; am Ende CW; Patel NC; Stiff C; Tran TP; Johnson DS
Expert Opin Ther Pat; 2011 Feb; 21(2):205-26. PubMed ID: 21231889
[TBL] [Abstract][Full Text] [Related]
15. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
Rynearson KD; Buckle RN; Herr RJ; Mayhew NJ; Chen X; Paquette WD; Sakwa SA; Yang J; Barnes KD; Nguyen P; Mobley WC; Johnson G; Lin JH; Tanzi RE; Wagner SL
Bioorg Med Chem; 2020 Nov; 28(22):115734. PubMed ID: 33007551
[TBL] [Abstract][Full Text] [Related]
16. Purine derivatives as potent gamma-secretase modulators.
Rivkin A; Ahearn SP; Chichetti SM; Hamblett CL; Garcia Y; Martinez M; Hubbs JL; Reutershan MH; Daniels MH; Siliphaivanh P; Otte KM; Li C; Rosenau A; Surdi LM; Jung J; Hughes BL; Crispino JL; Nikov GN; Middleton RE; Moxham CM; Szewczak AA; Shah S; Moy LY; Kenific CM; Tanga F; Cruz JC; Andrade P; Angagaw MH; Shomer NH; Miller T; Munoz B; Shearman MS
Bioorg Med Chem Lett; 2010 Apr; 20(7):2279-82. PubMed ID: 20207146
[TBL] [Abstract][Full Text] [Related]
17. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).
Takai T; Koike T; Nakamura M; Kajita Y; Yamashita T; Taya N; Tsukamoto T; Watanabe T; Murakami K; Igari T; Kamata M
Bioorg Med Chem; 2016 Jul; 24(14):3192-206. PubMed ID: 27255179
[TBL] [Abstract][Full Text] [Related]
18. Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.
Bursavich MG; Harrison BA; Acharya R; Costa DE; Freeman EA; Hodgdon HE; Hrdlicka LA; Jin H; Kapadnis S; Moffit JS; Murphy DA; Nolan S; Patzke H; Tang C; Wen M; Koenig G; Blain JF; Burnett DA
J Med Chem; 2017 Mar; 60(6):2383-2400. PubMed ID: 28230986
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.
Hieke M; Ness J; Steri R; Dittrich M; Greiner C; Werz O; Baumann K; Schubert-Zsilavecz M; Weggen S; Zettl H
J Med Chem; 2010 Jun; 53(12):4691-700. PubMed ID: 20503989
[TBL] [Abstract][Full Text] [Related]
20. The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Li H; Qin J; Dhondi P; Zhou W; Vicarel M; Bara T; Cole D; Josien H; Pissarnitski D; Zhu Z; Palani A; Aslanian R; Clader J; Czarniecki M; Greenlee W; Cohen-Williams M; Hyde L; Song L; Zhang L; Chu I; Huang X
Bioorg Med Chem Lett; 2013 Jan; 23(2):466-71. PubMed ID: 23253441
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
