169 related articles for article (PubMed ID: 31131010)
1. Concentration changes in gemcitabine and its metabolites after hyperthermia in pancreatic cancer cells assessed using RP-HPLC.
Jin HB; Lu L; Xie L; Yang JF; Zhang XF; Ma SL
Cell Mol Biol Lett; 2019; 24():30. PubMed ID: 31131010
[TBL] [Abstract][Full Text] [Related]
2. Simultaneous determination of gemcitabine prodrug, gemcitabine and its major metabolite 2', 2'-difluorodeoxyuridine in rat plasma by UFLC-MS/MS.
Sun Y; Zhen L; Peng Y; Wang J; Fei F; Aa L; Jiang W; Pei X; Lu L; Liu J; Wang G; Hao K
J Chromatogr B Analyt Technol Biomed Life Sci; 2018 May; 1084():4-13. PubMed ID: 29558739
[TBL] [Abstract][Full Text] [Related]
3. The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase.
Hodge LS; Taub ME; Tracy TS
Drug Metab Dispos; 2011 Nov; 39(11):2013-6. PubMed ID: 21832002
[TBL] [Abstract][Full Text] [Related]
4. A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.
Bapiro TE; Richards FM; Goldgraben MA; Olive KP; Madhu B; Frese KK; Cook N; Jacobetz MA; Smith DM; Tuveson DA; Griffiths JR; Jodrell DI
Cancer Chemother Pharmacol; 2011 Nov; 68(5):1243-53. PubMed ID: 21431415
[TBL] [Abstract][Full Text] [Related]
5. Intraperitoneal gemcitabine pharmacokinetics: a pilot and pharmacokinetic study in patients with advanced adenocarcinoma of the pancreas.
Gamblin TC; Egorin MJ; Zuhowski EG; Lagattuta TF; Herscher LL; Russo A; Libutti SK; Alexander HR; Dedrick RL; Bartlett DL
Cancer Chemother Pharmacol; 2008 Sep; 62(4):647-53. PubMed ID: 18040687
[TBL] [Abstract][Full Text] [Related]
6. In vitro studies on the immunosuppressive effect of 2',2'-difluorodeoxycytidine (dFdC) and its metabolite 2',2'-difluorodeoxyuridine (dFdU).
Tiefenthaler M; Hohla F; Irschick E; Strasser-Wozak E; Bacher N; Mühlmann O; Wein W; Konwalinka G
Immunobiology; 2003; 207(2):149-57. PubMed ID: 12675273
[TBL] [Abstract][Full Text] [Related]
7. Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice.
Veltkamp SA; Pluim D; van Tellingen O; Beijnen JH; Schellens JH
Drug Metab Dispos; 2008 Aug; 36(8):1606-15. PubMed ID: 18490432
[TBL] [Abstract][Full Text] [Related]
8. Simultaneous determination of gemcitabine and its main metabolite, dFdU, in plasma of patients with advanced non-small-cell lung cancer by high-performance liquid chromatography-tandem mass spectrometry.
Marangon E; Sala F; Caffo O; Galligioni E; D'Incalci M; Zucchetti M
J Mass Spectrom; 2008 Feb; 43(2):216-23. PubMed ID: 17941128
[TBL] [Abstract][Full Text] [Related]
9. LC-MS/MS method for quantitation of gemcitabine and its metabolite 2',2'-difluoro-2'-deoxyuridine in mouse plasma and brain tissue: Application to a preclinical pharmacokinetic study.
Zhong B; Gibson EG; Davis A; Roussel MF; Stewart CF
J Pharm Biomed Anal; 2021 May; 198():114025. PubMed ID: 33744463
[TBL] [Abstract][Full Text] [Related]
10. Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells.
Ohmine K; Kawaguchi K; Ohtsuki S; Motoi F; Egawa S; Unno M; Terasaki T
Pharm Res; 2012 Jul; 29(7):2006-16. PubMed ID: 22419259
[TBL] [Abstract][Full Text] [Related]
11. Investigation of the pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in human plasma by liquid chromatography.
Yilmaz B; Kadioğlu YY; Aksoy Y
Anal Biochem; 2004 Sep; 332(2):234-7. PubMed ID: 15325290
[TBL] [Abstract][Full Text] [Related]
12. Determination of gemcitabine and its metabolite in human plasma using high-pressure liquid chromatography coupled with a diode array detector.
Lin NM; Zeng S; Ma SL; Fan Y; Zhong HJ; Fang L
Acta Pharmacol Sin; 2004 Dec; 25(12):1584-9. PubMed ID: 15569401
[TBL] [Abstract][Full Text] [Related]
13. Mechanistic Multiscale Pharmacokinetic Model for the Anticancer Drug 2',2'-difluorodeoxycytidine (Gemcitabine) in Pancreatic Cancer.
Garcia-Cremades M; Melillo N; Troconiz IF; Magni P
Clin Transl Sci; 2020 May; 13(3):608-617. PubMed ID: 32043298
[TBL] [Abstract][Full Text] [Related]
14. New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine.
Veltkamp SA; Pluim D; van Eijndhoven MA; Bolijn MJ; Ong FH; Govindarajan R; Unadkat JD; Beijnen JH; Schellens JH
Mol Cancer Ther; 2008 Aug; 7(8):2415-25. PubMed ID: 18723487
[TBL] [Abstract][Full Text] [Related]
15. Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine.
Grunewald R; Abbruzzese JL; Tarassoff P; Plunkett W
Cancer Chemother Pharmacol; 1991; 27(4):258-62. PubMed ID: 1998982
[TBL] [Abstract][Full Text] [Related]
16. Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.
Bapiro TE; Frese KK; Courtin A; Bramhall JL; Madhu B; Cook N; Neesse A; Griffiths JR; Tuveson DA; Jodrell DI; Richards FM
Br J Cancer; 2014 Jul; 111(2):318-25. PubMed ID: 24874484
[TBL] [Abstract][Full Text] [Related]
17. Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours.
Ruiz van Haperen VW; Veerman G; Boven E; Noordhuis P; Vermorken JB; Peters GJ
Biochem Pharmacol; 1994 Oct; 48(7):1327-39. PubMed ID: 7945430
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine.
Honeywell RJ; Ruiz van Haperen VW; Veerman G; Smid K; Peters GJ
Int J Biochem Cell Biol; 2015 Mar; 60():73-81. PubMed ID: 25562513
[TBL] [Abstract][Full Text] [Related]
19. Measurement of the anti-cancer agent gemcitabine in human plasma by high-performance liquid chromatography.
Keith B; Xu Y; Grem JL
J Chromatogr B Analyt Technol Biomed Life Sci; 2003 Feb; 785(1):65-72. PubMed ID: 12535839
[TBL] [Abstract][Full Text] [Related]
20. A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high-performance liquid chromatography.
Nishi R; Yamauchi T; Ueda T
Cancer Sci; 2006 Nov; 97(11):1274-8. PubMed ID: 17034368
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
