BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 31132406)

  • 1. Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment.
    Deshmukh V; O'Green AL; Bossard C; Seo T; Lamangan L; Ibanez M; Ghias A; Lai C; Do L; Cho S; Cahiwat J; Chiu K; Pedraza M; Anderson S; Harris R; Dellamary L; Kc S; Barroga C; Melchior B; Tam B; Kennedy S; Tambiah J; Hood J; Yazici Y
    Osteoarthritis Cartilage; 2019 Sep; 27(9):1347-1360. PubMed ID: 31132406
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial.
    Yazici Y; McAlindon TE; Gibofsky A; Lane NE; Clauw D; Jones M; Bergfeld J; Swearingen CJ; DiFrancesco A; Simsek I; Tambiah J; Hochberg MC
    Arthritis Rheumatol; 2020 Oct; 72(10):1694-1706. PubMed ID: 32432388
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee.
    Deshmukh V; Hu H; Barroga C; Bossard C; Kc S; Dellamary L; Stewart J; Chiu K; Ibanez M; Pedraza M; Seo T; Do L; Cho S; Cahiwat J; Tam B; Tambiah JRS; Hood J; Lane NE; Yazici Y
    Osteoarthritis Cartilage; 2018 Jan; 26(1):18-27. PubMed ID: 28888902
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A Phase 2b randomized trial of lorecivivint, a novel intra-articular CLK2/DYRK1A inhibitor and Wnt pathway modulator for knee osteoarthritis.
    Yazici Y; McAlindon TE; Gibofsky A; Lane NE; Lattermann C; Skrepnik N; Swearingen CJ; Simsek I; Ghandehari H; DiFrancesco A; Gibbs J; Tambiah JRS; Hochberg MC
    Osteoarthritis Cartilage; 2021 May; 29(5):654-666. PubMed ID: 33588087
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Lorecivivint, an intra-articular potential disease-modifying osteoarthritis drug.
    Sabha M; Siaton BC; Hochberg MC
    Expert Opin Investig Drugs; 2020 Dec; 29(12):1339-1346. PubMed ID: 33096010
    [No Abstract]   [Full Text] [Related]  

  • 6. A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study.
    Yazici Y; McAlindon TE; Fleischmann R; Gibofsky A; Lane NE; Kivitz AJ; Skrepnik N; Armas E; Swearingen CJ; DiFrancesco A; Tambiah JRS; Hood J; Hochberg MC
    Osteoarthritis Cartilage; 2017 Oct; 25(10):1598-1606. PubMed ID: 28711582
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A small-molecule inhibitor of the Wnt pathway, lorecivivint (SM04690), as a potential disease-modifying agent for the treatment of degenerative disc disease.
    Deshmukh V; Ibanez M; Hu H; Cahiwat J; Wei Y; Stewart J; Hood J; Yazici Y
    Spine J; 2020 Sep; 20(9):1492-1502. PubMed ID: 32413487
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis.
    Sun Y; Hu T; Zhang M; Song J; Qin Z; Liu M; Ji J; Li Z; Qiu Z; Bian J
    J Med Chem; 2024 Mar; 67(6):4603-4623. PubMed ID: 38500250
    [TBL] [Abstract][Full Text] [Related]  

  • 9. SM04755, a small-molecule inhibitor of the Wnt pathway, as a potential topical treatment for tendinopathy.
    Deshmukh V; Seo T; O'Green AL; Ibanez M; Hofilena B; Kc S; Stewart J; Dellamary L; Chiu K; Ghias A; Barroga C; Kennedy S; Tambiah J; Hood J; Yazici Y
    J Orthop Res; 2021 Sep; 39(9):2048-2061. PubMed ID: 33104243
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Intra-articular injection of a novel Wnt pathway inhibitor, SM04690, upregulates Wnt16 expression and reduces disease progression in temporomandibular joint osteoarthritis.
    Hua B; Qiu J; Ye X; Liu X
    Bone; 2022 May; 158():116372. PubMed ID: 35218985
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/β-catenin signaling pathway.
    Xia H; Cao D; Yang F; Yang W; Li W; Liu P; Wang S; Yang F
    Biomed Pharmacother; 2020 Feb; 122():109708. PubMed ID: 31918279
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.
    Lee SY; Lee SH; Na HS; Kwon JY; Kim GY; Jung K; Cho KH; Kim SA; Go EJ; Park MJ; Baek JA; Choi SY; Jhun J; Park SH; Kim SJ; Cho ML
    Front Immunol; 2018; 9():2881. PubMed ID: 30619261
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Individual Participant Symptom Responses to Intra-Articular Lorecivivint in Knee Osteoarthritis: Post Hoc Analysis of a Phase 2B Trial.
    Tambiah JRS; Kennedy S; Swearingen CJ; Simsek I; Yazici Y; Farr J; Conaghan PG
    Rheumatol Ther; 2021 Jun; 8(2):973-985. PubMed ID: 34101138
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Wnt signaling: a promising target for osteoarthritis therapy.
    Wang Y; Fan X; Xing L; Tian F
    Cell Commun Signal; 2019 Aug; 17(1):97. PubMed ID: 31420042
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Artemisinin Ameliorates Osteoarthritis by Inhibiting the Wnt/β-Catenin Signaling Pathway.
    Zhong G; Liang R; Yao J; Li J; Jiang T; Liu J; Le Y; Shen C; Long H; Lu H; Ma S; Luo J; Miao Z; Su W; Zheng L; Zhao J
    Cell Physiol Biochem; 2018; 51(6):2575-2590. PubMed ID: 30562742
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effect of lorecivivint on osteoarthritis: A systematic review and meta-analysis.
    Kou H; Qing Z; Zhao G; Sun X; Zhi L; Wang J; Chen X; Guo H; Zhang R; Ma J
    Heliyon; 2023 Aug; 9(8):e18682. PubMed ID: 37576256
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis.
    Lietman C; Wu B; Lechner S; Shinar A; Sehgal M; Rossomacha E; Datta P; Sharma A; Gandhi R; Kapoor M; Young PP
    JCI Insight; 2018 Feb; 3(3):. PubMed ID: 29415892
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Naringenin regulates production of matrix metalloproteinases in the knee-joint and primary cultured articular chondrocytes and alleviates pain in rat osteoarthritis model.
    Wang CC; Guo L; Tian FD; An N; Luo L; Hao RH; Wang B; Zhou ZH
    Braz J Med Biol Res; 2017 Mar; 50(4):e5714. PubMed ID: 28355351
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Development of Cdc2-like Kinase 2 Inhibitors: Achievements and Future Directions.
    Qin Z; Qin L; Feng X; Li Z; Bian J
    J Med Chem; 2021 Sep; 64(18):13191-13211. PubMed ID: 34519506
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.
    Huang J; Chen C; Liang C; Luo P; Xia G; Zhang L; Wang X; Wen Z; Cao X; Wu S
    Stem Cells Dev; 2020 Apr; 29(7):401-413. PubMed ID: 31964233
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.