BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

428 related articles for article (PubMed ID: 31142647)

  • 1. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
    Xie W; Lama L; Adura C; Tomita D; Glickman JF; Tuschl T; Patel DJ
    Proc Natl Acad Sci U S A; 2019 Jun; 116(24):11946-11955. PubMed ID: 31142647
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
    Hall J; Ralph EC; Shanker S; Wang H; Byrnes LJ; Horst R; Wong J; Brault A; Dumlao D; Smith JF; Dakin LA; Schmitt DC; Trujillo J; Vincent F; Griffor M; Aulabaugh AE
    Protein Sci; 2017 Dec; 26(12):2367-2380. PubMed ID: 28940468
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase.
    Tao X; Song J; Song Y; Zhang Y; Yang J; Zhang P; Zhang D; Chen D; Sun Q
    Cell Rep; 2022 Sep; 40(10):111310. PubMed ID: 36070696
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DNA-induced liquid phase condensation of cGAS activates innate immune signaling.
    Du M; Chen ZJ
    Science; 2018 Aug; 361(6403):704-709. PubMed ID: 29976794
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
    Li X; Shu C; Yi G; Chaton CT; Shelton CL; Diao J; Zuo X; Kao CC; Herr AB; Li P
    Immunity; 2013 Dec; 39(6):1019-31. PubMed ID: 24332030
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Analysis of human cGAS activity and structure.
    Zhou W; Whiteley AT; Kranzusch PJ
    Methods Enzymol; 2019; 625():13-40. PubMed ID: 31455523
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular mechanisms and cellular functions of cGAS-STING signalling.
    Hopfner KP; Hornung V
    Nat Rev Mol Cell Biol; 2020 Sep; 21(9):501-521. PubMed ID: 32424334
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.
    Zhang X; Wu J; Du F; Xu H; Sun L; Chen Z; Brautigam CA; Zhang X; Chen ZJ
    Cell Rep; 2014 Feb; 6(3):421-30. PubMed ID: 24462292
    [TBL] [Abstract][Full Text] [Related]  

  • 9. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.
    Almine JF; O'Hare CA; Dunphy G; Haga IR; Naik RJ; Atrih A; Connolly DJ; Taylor J; Kelsall IR; Bowie AG; Beard PM; Unterholzner L
    Nat Commun; 2017 Feb; 8():14392. PubMed ID: 28194029
    [TBL] [Abstract][Full Text] [Related]  

  • 10. [Cytosolic DNA sensing by the cGAS-STING pathway in cancer].
    Chanut R; Petrilli V
    Med Sci (Paris); 2019; 35(6-7):527-534. PubMed ID: 31274082
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.
    Hu MM; Yang Q; Xie XQ; Liao CY; Lin H; Liu TT; Yin L; Shu HB
    Immunity; 2016 Sep; 45(3):555-569. PubMed ID: 27637147
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
    Zhou W; Whiteley AT; de Oliveira Mann CC; Morehouse BR; Nowak RP; Fischer ES; Gray NS; Mekalanos JJ; Kranzusch PJ
    Cell; 2018 Jul; 174(2):300-311.e11. PubMed ID: 30007416
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural basis for sequestration and autoinhibition of cGAS by chromatin.
    Michalski S; de Oliveira Mann CC; Stafford CA; Witte G; Bartho J; Lammens K; Hornung V; Hopfner KP
    Nature; 2020 Nov; 587(7835):678-682. PubMed ID: 32911480
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response.
    Lian H; Wei J; Zang R; Ye W; Yang Q; Zhang XN; Chen YD; Fu YZ; Hu MM; Lei CQ; Luo WW; Li S; Shu HB
    Nat Commun; 2018 Aug; 9(1):3349. PubMed ID: 30135424
    [TBL] [Abstract][Full Text] [Related]  

  • 15. cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1.
    Gamdzyk M; Doycheva DM; Araujo C; Ocak U; Luo Y; Tang J; Zhang JH
    Mol Neurobiol; 2020 Jun; 57(6):2600-2619. PubMed ID: 32253733
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
    Sun H; Huang Y; Mei S; Xu F; Liu X; Zhao F; Yin L; Zhang D; Wei L; Wu C; Ma S; Wang J; Cen S; Liang C; Hu S; Guo F
    Cell Rep; 2021 Jan; 34(1):108586. PubMed ID: 33406424
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling.
    Cai X; Chiu YH; Chen ZJ
    Mol Cell; 2014 Apr; 54(2):289-96. PubMed ID: 24766893
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Assessing the cGAS-cGAMP-STING Activity of Cancer Cells.
    Pépin G; Gantier MP
    Methods Mol Biol; 2018; 1725():257-266. PubMed ID: 29322423
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Regulation of cGAS.
    Xiong M; Wang S; Wang YY; Ran Y
    Virol Sin; 2018 Apr; 33(2):117-124. PubMed ID: 29546673
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.
    Gu H; Yang J; Zhang J; Song Y; Zhang Y; Xu P; Zhu Y; Wang L; Zhang P; Li L; Chen D; Sun Q
    Nat Commun; 2022 Mar; 13(1):1564. PubMed ID: 35322803
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.