These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Jiang H; Deng R; Yang X; Shang J; Lu S; Zhao Y; Song K; Liu X; Zhang Q; Chen Y; Chinn YE; Wu G; Li J; Chen G; Yu J; Zhang J Nat Chem Biol; 2017 Sep; 13(9):994-1001. PubMed ID: 28759015 [TBL] [Abstract][Full Text] [Related]
5. Dihydropyrazole Derivatives Containing Benzo Oxygen Heterocycle and Sulfonamide Moieties Selectively and Potently Inhibit COX-2: Design, Synthesis, and Anti-Colon Cancer Activity Evaluation. Yan XQ; Wang ZC; Zhang B; Qi PF; Li GG; Zhu HL Molecules; 2019 Apr; 24(9):. PubMed ID: 31052167 [TBL] [Abstract][Full Text] [Related]
6. Structural basis for the recognition of Asef by adenomatous polyposis coli. Zhang Z; Chen L; Gao L; Lin K; Zhu L; Lu Y; Shi X; Gao Y; Zhou J; Xu P; Zhang J; Wu G Cell Res; 2012 Feb; 22(2):372-86. PubMed ID: 21788986 [TBL] [Abstract][Full Text] [Related]
7. Rational Design and Structure Validation of a Novel Peptide Inhibitor of the Adenomatous-Polyposis-Coli (APC)-Rho-Guanine-Nucleotide-Exchange-Factor-4 (Asef) Interaction. Yang X; Zhong J; Zhang Q; Qian J; Song K; Ruan C; Xu J; Ding K; Zhang J J Med Chem; 2018 Sep; 61(17):8017-8028. PubMed ID: 30095910 [TBL] [Abstract][Full Text] [Related]
8. Rational design of a sensitivity-enhanced tracer for discovering efficient APC-Asef inhibitors. Zhong J; Guo Y; Lu S; Song K; Wang Y; Feng L; Zheng Z; Zhang Q; Wei J; Sang P; Shi Y; Cai J; Chen G; Liu CY; Yang X; Zhang J Nat Commun; 2022 Aug; 13(1):4961. PubMed ID: 36002443 [TBL] [Abstract][Full Text] [Related]
9. Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors. He X; Huang N; Qiu Y; Zhang J; Liu Y; Yin XL; Lu S Molecules; 2021 Feb; 26(4):. PubMed ID: 33670371 [TBL] [Abstract][Full Text] [Related]
10. Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy. Yang X; Zhong J; Zhang Q; Feng L; Zheng Z; Zhang J; Lu S Front Mol Biosci; 2021; 8():662579. PubMed ID: 33968990 [TBL] [Abstract][Full Text] [Related]
11. The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. Kawasaki Y; Jigami T; Furukawa S; Sagara M; Echizen K; Shibata Y; Sato R; Akiyama T J Biol Chem; 2010 Jan; 285(2):1199-207. PubMed ID: 19897489 [TBL] [Abstract][Full Text] [Related]
12. Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase. Kawasaki Y; Tsuji S; Sagara M; Echizen K; Shibata Y; Akiyama T J Biol Chem; 2009 Aug; 284(33):22436-22443. PubMed ID: 19525225 [TBL] [Abstract][Full Text] [Related]
13. Asef, a link between the tumor suppressor APC and G-protein signaling. Kawasaki Y; Senda T; Ishidate T; Koyama R; Morishita T; Iwayama Y; Higuchi O; Akiyama T Science; 2000 Aug; 289(5482):1194-7. PubMed ID: 10947987 [TBL] [Abstract][Full Text] [Related]
14. Structure-based discovery of small molecule APC-Asef interaction inhibitors: In silico approaches and molecular dynamics simulations. Jadav SS; Macalino SJY; Alluri R J Mol Model; 2020 Jul; 26(8):207. PubMed ID: 32676810 [TBL] [Abstract][Full Text] [Related]
15. The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. Kawasaki Y; Tsuji S; Muroya K; Furukawa S; Shibata Y; Okuno M; Ohwada S; Akiyama T EMBO Rep; 2009 Dec; 10(12):1355-62. PubMed ID: 19893577 [TBL] [Abstract][Full Text] [Related]
16. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Kawasaki Y; Sagara M; Shibata Y; Shirouzu M; Yokoyama S; Akiyama T Oncogene; 2007 Dec; 26(55):7620-267. PubMed ID: 17599059 [TBL] [Abstract][Full Text] [Related]
17. Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Mitin N; Betts L; Yohe ME; Der CJ; Sondek J; Rossman KL Nat Struct Mol Biol; 2007 Sep; 14(9):814-23. PubMed ID: 17704816 [TBL] [Abstract][Full Text] [Related]
18. Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC). Wang W; Zhang L; Morlock L; Williams NS; Shay JW; De Brabander JK J Med Chem; 2019 May; 62(10):5217-5241. PubMed ID: 31070915 [TBL] [Abstract][Full Text] [Related]
19. Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents. Li Z; Wang ZC; Li X; Abbas M; Wu SY; Ren SZ; Liu QX; Liu Y; Chen PW; Duan YT; Lv PC; Zhu HL Eur J Med Chem; 2019 May; 169():168-184. PubMed ID: 30877972 [TBL] [Abstract][Full Text] [Related]
20. Differences in the localization of the adenomatous polyposis coli-Asef/Asef2 complex between adenomatous polyposis coli wild-type and mutant cells. Kawasaki Y; Furukawa S; Sato R; Akiyama T Cancer Sci; 2013 Aug; 104(8):1135-8. PubMed ID: 23910005 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]