These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

409 related articles for article (PubMed ID: 31165876)

  • 1. mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway.
    Liang XH; Nichols JG; Hsu CW; Vickers TA; Crooke ST
    Nucleic Acids Res; 2019 Jul; 47(13):6900-6916. PubMed ID: 31165876
    [TBL] [Abstract][Full Text] [Related]  

  • 2. RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides.
    Hori SI; Mitsuoka Y; Kugimiya A
    Nucleic Acid Ther; 2019 Feb; 29(1):44-50. PubMed ID: 30508397
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides.
    Ward AJ; Norrbom M; Chun S; Bennett CF; Rigo F
    Nucleic Acids Res; 2014 May; 42(9):5871-9. PubMed ID: 24589581
    [TBL] [Abstract][Full Text] [Related]  

  • 4. RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus.
    Liang XH; Sun H; Nichols JG; Crooke ST
    Mol Ther; 2017 Sep; 25(9):2075-2092. PubMed ID: 28663102
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.
    Shen W; De Hoyos CL; Sun H; Vickers TA; Liang XH; Crooke ST
    Nucleic Acids Res; 2018 Mar; 46(5):2204-2217. PubMed ID: 29390093
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins.
    Zhang L; Vickers TA; Sun H; Liang XH; Crooke ST
    Nucleic Acids Res; 2021 Mar; 49(5):2721-2739. PubMed ID: 33577678
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
    Burel SA; Hart CE; Cauntay P; Hsiao J; Machemer T; Katz M; Watt A; Bui HH; Younis H; Sabripour M; Freier SM; Hung G; Dan A; Prakash TP; Seth PP; Swayze EE; Bennett CF; Crooke ST; Henry SP
    Nucleic Acids Res; 2016 Mar; 44(5):2093-109. PubMed ID: 26553810
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs.
    Liang XH; Nichols JG; Sun H; Crooke ST
    Nucleic Acids Res; 2018 Jan; 46(1):293-313. PubMed ID: 29165591
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity.
    Liang XH; Shen W; Sun H; Kinberger GA; Prakash TP; Nichols JG; Crooke ST
    Nucleic Acids Res; 2016 May; 44(8):3892-907. PubMed ID: 26945041
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.
    Liang XH; Sun H; Shen W; Crooke ST
    Nucleic Acids Res; 2015 Mar; 43(5):2927-45. PubMed ID: 25712094
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides.
    Zhang L; Bernardo KD; Vickers TA; Tian J; Liang XH; Crooke ST
    Nucleic Acid Ther; 2022 Aug; 32(4):280-299. PubMed ID: 35852833
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotides.
    Hasselblatt P; Hockenjos B; Thoma C; Blum HE; Offensperger WB
    Nucleic Acids Res; 2005; 33(1):114-25. PubMed ID: 15640448
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations.
    Huang L; Low A; Damle SS; Keenan MM; Kuntz S; Murray SF; Monia BP; Guo S
    Genome Biol; 2018 Jan; 19(1):4. PubMed ID: 29334995
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms.
    Vickers TA; Crooke ST
    PLoS One; 2014; 9(10):e108625. PubMed ID: 25299183
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination.
    Lai F; Damle SS; Ling KK; Rigo F
    Mol Cell; 2020 Mar; 77(5):1032-1043.e4. PubMed ID: 31924447
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Phosphorothioate Antisense Oligonucleotides Bind P-Body Proteins and Mediate P-Body Assembly.
    Wang Y; Shen W; Liang XH; Crooke ST
    Nucleic Acid Ther; 2019 Dec; 29(6):343-358. PubMed ID: 31429620
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation.
    Hvam ML; Cai Y; Dagnæs-Hansen F; Nielsen JS; Wengel J; Kjems J; Howard KA
    Mol Ther; 2017 Jul; 25(7):1710-1717. PubMed ID: 28641935
    [TBL] [Abstract][Full Text] [Related]  

  • 18. XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides.
    Hori S; Yamamoto T; Obika S
    Biochem Biophys Res Commun; 2015 Aug; 464(2):506-11. PubMed ID: 26159921
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity.
    Liang XH; Nichols JG; De Hoyos CL; Crooke ST
    Nucleic Acids Res; 2020 Sep; 48(17):9840-9858. PubMed ID: 32870273
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-
    Zhang L; Liang XH; De Hoyos CL; Migawa M; Nichols JG; Freestone G; Tian J; Seth PP; Crooke ST
    Nucleic Acid Ther; 2022 Oct; 32(5):401-411. PubMed ID: 35861704
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.