282 related articles for article (PubMed ID: 31168089)
1. Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric G
Qi X; Liu H; Thompson B; McDonald J; Zhang C; Li X
Nature; 2019 Jul; 571(7764):279-283. PubMed ID: 31168089
[TBL] [Abstract][Full Text] [Related]
2. Measuring Smoothened (SMO)-Mediated Activation of the G
Liu H; Zhang C
Methods Mol Biol; 2022; 2374():205-212. PubMed ID: 34562255
[TBL] [Abstract][Full Text] [Related]
3. Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins.
Polizio AH; Chinchilla P; Chen X; Manning DR; Riobo NA
Sci Signal; 2011 Nov; 4(200):pt7. PubMed ID: 22114142
[TBL] [Abstract][Full Text] [Related]
4. Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia.
Ho Wei L; Arastoo M; Georgiou I; Manning DR; Riobo-Del Galdo NA
PLoS One; 2018; 13(8):e0203170. PubMed ID: 30148884
[TBL] [Abstract][Full Text] [Related]
5. Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex.
Vo AP; Kim SK; Yang MY; Ondrus AE; Goddard WA
Proc Natl Acad Sci U S A; 2023 Dec; 120(49):e2300919120. PubMed ID: 38015850
[TBL] [Abstract][Full Text] [Related]
6. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Deshpande I; Liang J; Hedeen D; Roberts KJ; Zhang Y; Ha B; Latorraca NR; Faust B; Dror RO; Beachy PA; Myers BR; Manglik A
Nature; 2019 Jul; 571(7764):284-288. PubMed ID: 31263273
[TBL] [Abstract][Full Text] [Related]
7. G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
Ogden SK; Fei DL; Schilling NS; Ahmed YF; Hwa J; Robbins DJ
Nature; 2008 Dec; 456(7224):967-70. PubMed ID: 18987629
[TBL] [Abstract][Full Text] [Related]
8. Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Qi X; Friedberg L; De Bose-Boyd R; Long T; Li X
Nat Chem Biol; 2020 Dec; 16(12):1368-1375. PubMed ID: 32929279
[TBL] [Abstract][Full Text] [Related]
9. Sterol regulation of developmental and oncogenic Hedgehog signaling.
Daggubati V; Raleigh DR; Sever N
Biochem Pharmacol; 2022 Feb; 196():114647. PubMed ID: 34111427
[TBL] [Abstract][Full Text] [Related]
10. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium.
Carbe CJ; Cheng L; Addya S; Gold JI; Gao E; Koch WJ; Riobo NA
Am J Physiol Heart Circ Physiol; 2014 Jul; 307(1):H66-72. PubMed ID: 24816261
[TBL] [Abstract][Full Text] [Related]
11. Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling.
Desai PB; Stuck MW; Lv B; Pazour GJ
J Cell Biol; 2020 Jul; 219(7):. PubMed ID: 32435793
[TBL] [Abstract][Full Text] [Related]
12. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K
Cheng L; Al-Owais M; Covarrubias ML; Koch WJ; Manning DR; Peers C; Riobo-Del Galdo NA
J Biol Chem; 2018 Jul; 293(28):11022-11032. PubMed ID: 29802197
[TBL] [Abstract][Full Text] [Related]
13. Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.
Bijlsma MF; Spek CA; Zivkovic D; van de Water S; Rezaee F; Peppelenbosch MP
PLoS Biol; 2006 Jul; 4(8):e232. PubMed ID: 16895439
[TBL] [Abstract][Full Text] [Related]
14. A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine.
Kozielewicz P; Bowin CF; Turku A; Schulte G
Mol Pharmacol; 2020 Jan; 97(1):23-34. PubMed ID: 31707356
[TBL] [Abstract][Full Text] [Related]
15. Activation of heterotrimeric G proteins by Smoothened.
Riobo NA; Saucy B; Dilizio C; Manning DR
Proc Natl Acad Sci U S A; 2006 Aug; 103(33):12607-12. PubMed ID: 16885213
[TBL] [Abstract][Full Text] [Related]
16. Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.
Kowatsch C; Woolley RE; Kinnebrew M; Rohatgi R; Siebold C
Curr Opin Struct Biol; 2019 Aug; 57():204-214. PubMed ID: 31247512
[TBL] [Abstract][Full Text] [Related]
17. Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration.
Polizio AH; Chinchilla P; Chen X; Kim S; Manning DR; Riobo NA
J Biol Chem; 2011 Jun; 286(22):19589-96. PubMed ID: 21474452
[TBL] [Abstract][Full Text] [Related]
18. Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.
Kim Y; Lee J; Seppala M; Cobourne MT; Kim SH
Nat Commun; 2020 Apr; 11(1):1994. PubMed ID: 32332736
[TBL] [Abstract][Full Text] [Related]
19. The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.
Grzelak CA; Martelotto LG; Sigglekow ND; Patkunanathan B; Ajami K; Calabro SR; Dwyer BJ; Tirnitz-Parker JE; Watkins DN; Warner FJ; Shackel NA; McCaughan GW
J Hepatol; 2014 Jan; 60(1):143-51. PubMed ID: 23978713
[TBL] [Abstract][Full Text] [Related]
20. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.
Wilson CW; Chen MH; Chuang PT
PLoS One; 2009; 4(4):e5182. PubMed ID: 19365551
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]