BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

294 related articles for article (PubMed ID: 31200235)

  • 1. Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents.
    Gao T; Zhang C; Shi X; Guo R; Zhang K; Gu J; Li L; Li S; Zheng Q; Cui M; Cui M; Gao X; Liu Y; Wang L
    Eur J Med Chem; 2019 Sep; 178():329-340. PubMed ID: 31200235
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents.
    Tian C; Wang M; Han Z; Fang F; Zhang Z; Wang X; Liu J
    Eur J Med Chem; 2017 Sep; 138():630-643. PubMed ID: 28711701
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis.
    Liu Y; Zhang C; Zhang H; Li M; Yuan J; Zhang Y; Zhou J; Guo H; Zhao L; Du Y; Wang L; Ren L
    Eur J Med Chem; 2015 Mar; 93():142-55. PubMed ID: 25668494
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.
    Xing R; Zhang H; Yuan J; Zhang K; Li L; Guo H; Zhao L; Zhang C; Li S; Gao T; Liu Y; Wang L
    Eur J Med Chem; 2017 Oct; 139():531-541. PubMed ID: 28830032
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).
    Gangjee A; Jain HD; Phan J; Lin X; Song X; McGuire JJ; Kisliuk RL
    J Med Chem; 2006 Feb; 49(3):1055-65. PubMed ID: 16451071
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
    Gangjee A; Vidwans A; Elzein E; McGuire JJ; Queener SF; Kisliuk RL
    J Med Chem; 2001 Jun; 44(12):1993-2003. PubMed ID: 11384244
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
    Gangjee A; Lin X; Kisliuk RL; McGuire JJ
    J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.
    Gangjee A; Zeng Y; Talreja T; McGuire JJ; Kisliuk RL; Queener SF
    J Med Chem; 2007 Jun; 50(13):3046-53. PubMed ID: 17552508
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
    Gangjee A; Jain HD; Queener SF; Kisliuk RL
    J Med Chem; 2008 Aug; 51(15):4589-600. PubMed ID: 18605720
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents.
    Liu Y; Li M; Zhang H; Yuan J; Zhang C; Zhang K; Guo H; Zhao L; Du Y; Wang L; Ren L
    Eur J Med Chem; 2016 Jun; 115():245-56. PubMed ID: 27017552
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge.
    Li H; Fang F; Liu Y; Xue L; Wang M; Guo Y; Wang X; Tian C; Liu J; Zhang Z
    Bioorg Med Chem; 2018 May; 26(9):2674-2685. PubMed ID: 29691154
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
    Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
    J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
    Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF
    J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.
    Gangjee A; Zeng Y; McGuire JJ; Kisliuk RL
    J Med Chem; 2005 Aug; 48(16):5329-36. PubMed ID: 16078850
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase.
    Wang M; Yang J; Yuan M; Xue L; Li H; Tian C; Wang X; Liu J; Zhang Z
    Eur J Med Chem; 2017 Mar; 128():88-97. PubMed ID: 28152430
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.
    Gangjee A; Li W; Yang J; Kisliuk RL
    J Med Chem; 2008 Jan; 51(1):68-76. PubMed ID: 18072727
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.
    Gangjee A; Yu J; Kisliuk RL; Haile WH; Sobrero G; McGuire JJ
    J Med Chem; 2003 Feb; 46(4):591-600. PubMed ID: 12570380
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity.
    Gangjee A; Zeng Y; Ihnat M; Warnke LA; Green DW; Kisliuk RL; Lin FT
    Bioorg Med Chem; 2005 Sep; 13(18):5475-91. PubMed ID: 16039863
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
    Wang Y; Cherian C; Orr S; Mitchell-Ryan S; Hou Z; Raghavan S; Matherly LH; Gangjee A
    J Med Chem; 2013 Nov; 56(21):8684-95. PubMed ID: 24111942
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
    Shah K; Lin X; Queener SF; Cody V; Pace J; Gangjee A
    Bioorg Med Chem; 2018 May; 26(9):2640-2650. PubMed ID: 29691153
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.