165 related articles for article (PubMed ID: 31205503)
1. Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer.
Kim EY; Lee JG; Lee JM; Kim A; Yoo HC; Kim K; Lee M; Lee C; Han G; Han JM; Chang YS
Ther Adv Med Oncol; 2019; 11():1758835919846798. PubMed ID: 31205503
[TBL] [Abstract][Full Text] [Related]
2. Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.
Choi H; Son JB; Kang J; Kwon J; Kim JH; Jung M; Kim SK; Kim S; Mun JY
Biochem Biophys Res Commun; 2017 Nov; 493(2):1129-1135. PubMed ID: 28882589
[TBL] [Abstract][Full Text] [Related]
3. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.
Kim JH; Lee C; Lee M; Wang H; Kim K; Park SJ; Yoon I; Jang J; Zhao H; Kim HK; Kwon NH; Jeong SJ; Yoo HC; Kim JH; Yang JS; Lee MY; Lee CW; Yun J; Oh SJ; Kang JS; Martinis SA; Hwang KY; Guo M; Han G; Han JM; Kim S
Nat Commun; 2017 Sep; 8(1):732. PubMed ID: 28963468
[TBL] [Abstract][Full Text] [Related]
4. Combination of the LARS1 Inhibitor, BC-LI-0186 with a MEK1/2 Inhibitor Enhances the Anti-Tumor Effect in Non-Small Cell Lung Cancer.
Lee SH; Kim EY; Han JM; Han G; Chang YS
Cancer Res Treat; 2023 Jul; 55(3):851-864. PubMed ID: 36960627
[TBL] [Abstract][Full Text] [Related]
5. Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction.
Kim JH; Jung K; Lee C; Song D; Kim K; Yoo HC; Park SJ; Kang JS; Lee KR; Kim S; Han JM; Han G
Bioorg Chem; 2021 Jul; 112():104907. PubMed ID: 33979735
[TBL] [Abstract][Full Text] [Related]
6. Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration.
Son K; You JS; Yoon MS; Dai C; Kim JH; Khanna N; Banerjee A; Martinis SA; Han G; Han JM; Kim S; Chen J
J Clin Invest; 2019 Apr; 129(5):2088-2093. PubMed ID: 30985292
[TBL] [Abstract][Full Text] [Related]
7. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
Lee M; Kim JH; Yoon I; Lee C; Fallahi Sichani M; Kang JS; Kang J; Guo M; Lee KY; Han G; Kim S; Han JM
Proc Natl Acad Sci U S A; 2018 Jun; 115(23):E5279-E5288. PubMed ID: 29784813
[TBL] [Abstract][Full Text] [Related]
8. Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S; Kim JH; Koh Y; Tran PT; Ann J; Yoon I; Jang J; Kim WK; Lee S; Lee J; Kim S; Lee J
Bioorg Med Chem; 2017 Aug; 25(15):4145-4152. PubMed ID: 28625715
[TBL] [Abstract][Full Text] [Related]
9. LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase.
Ho DH; Kim H; Nam D; Sim H; Kim J; Kim HG; Son I; Seol W
Cell Biochem Funct; 2018 Dec; 36(8):431-442. PubMed ID: 30411383
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Yoon S; Kim SE; Kim JH; Yoon I; Tran PT; Ann J; Kim C; Byun WS; Lee S; Kim S; Lee J; Lee J
Bioorg Med Chem; 2019 Mar; 27(6):1099-1109. PubMed ID: 30755350
[TBL] [Abstract][Full Text] [Related]
11. Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.
Yoon S; Kim JH; Yoon I; Kim C; Kim SE; Koh Y; Jeong SJ; Lee J; Kim S; Lee J
Bioorg Med Chem Lett; 2016 Jul; 26(13):3038-3041. PubMed ID: 27209231
[TBL] [Abstract][Full Text] [Related]
12. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
Han JM; Jeong SJ; Park MC; Kim G; Kwon NH; Kim HK; Ha SH; Ryu SH; Kim S
Cell; 2012 Apr; 149(2):410-24. PubMed ID: 22424946
[TBL] [Abstract][Full Text] [Related]
13. Methionyl-tRNA synthetase overexpression is associated with poor clinical outcomes in non-small cell lung cancer.
Kim EY; Jung JY; Kim A; Kim K; Chang YS
BMC Cancer; 2017 Jul; 17(1):467. PubMed ID: 28679377
[TBL] [Abstract][Full Text] [Related]
14. Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S; Zuo D; Kim JH; Yoon I; Ann J; Kim SE; Cho D; Kim WK; Lee S; Lee J; Kim S; Lee J
Bioorg Med Chem; 2018 Aug; 26(14):4073-4079. PubMed ID: 30041947
[TBL] [Abstract][Full Text] [Related]
15. Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling.
Yoon MS; Son K; Arauz E; Han JM; Kim S; Chen J
Cell Rep; 2016 Aug; 16(6):1510-1517. PubMed ID: 27477288
[TBL] [Abstract][Full Text] [Related]
16. Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors.
Yoon S; Kim JH; Kim SE; Kim C; Tran PT; Ann J; Koh Y; Jang J; Kim S; Moon HS; Kim WK; Lee S; Lee J; Kim S; Lee J
J Med Chem; 2016 Nov; 59(22):10322-10328. PubMed ID: 27933890
[TBL] [Abstract][Full Text] [Related]
17. Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy.
You JS; Karaman K; Reyes-OrdoƱez A; Lee S; Kim Y; Bashir R; Chen J
Am J Pathol; 2024 May; ():. PubMed ID: 38762116
[TBL] [Abstract][Full Text] [Related]
18. PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
D'Hulst G; Soro-Arnaiz I; Masschelein E; Veys K; Fitzgerald G; Smeuninx B; Kim S; Deldicque L; Blaauw B; Carmeliet P; Breen L; Koivunen P; Zhao SM; De Bock K
Nat Commun; 2020 Jan; 11(1):174. PubMed ID: 31924757
[TBL] [Abstract][Full Text] [Related]
19. Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Kim S; Yoon I; Son J; Park J; Kim K; Lee JH; Park SY; Kang BS; Han JM; Hwang KY; Kim S
Cell Rep; 2021 Apr; 35(4):109031. PubMed ID: 33910001
[TBL] [Abstract][Full Text] [Related]
20. Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction.
Ito M; Yurube T; Kakutani K; Maeno K; Takada T; Terashima Y; Kakiuchi Y; Takeoka Y; Miyazaki S; Kuroda R; Nishida K
Osteoarthritis Cartilage; 2017 Dec; 25(12):2134-2146. PubMed ID: 28888905
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]