These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

353 related articles for article (PubMed ID: 31225454)

  • 1. Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase.
    Steiner H; Fukumori A; Tagami S; Okochi M
    Cell Stress; 2018 Oct; 2(11):292-310. PubMed ID: 31225454
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pathogenic Aβ generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications.
    Trambauer J; Fukumori A; Steiner H
    Curr Opin Neurobiol; 2020 Apr; 61():73-81. PubMed ID: 32105841
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substrate recruitment by γ-secretase.
    Fukumori A; Feilen LP; Steiner H
    Semin Cell Dev Biol; 2020 Sep; 105():54-63. PubMed ID: 32331992
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
    Kretner B; Fukumori A; Kuhn PH; Pérez-Revuelta BI; Lichtenthaler SF; Haass C; Steiner H
    J Neurochem; 2013 Apr; 125(1):144-56. PubMed ID: 23237322
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Commentary: Abeta N- Terminal Isoforms: Critical contributors in the course of AD pathophysiology.
    Tekirian TL
    J Alzheimers Dis; 2001 Apr; 3(2):241-248. PubMed ID: 12214065
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease.
    Wolfe MS
    Biol Chem; 2012 Sep; 393(9):899-905. PubMed ID: 22944690
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
    Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
    J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.
    Yang T; Arslanova D; Gu Y; Augelli-Szafran C; Xia W
    Mol Brain; 2008 Nov; 1():15. PubMed ID: 18983676
    [TBL] [Abstract][Full Text] [Related]  

  • 9. BACE1: the beta-secretase enzyme in Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
    [TBL] [Abstract][Full Text] [Related]  

  • 10. γ-Secretase and its modulators: Twenty years and beyond.
    Xia W
    Neurosci Lett; 2019 May; 701():162-169. PubMed ID: 30763650
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators.
    Trambauer J; Fukumori A; Kretner B; Steiner H
    Methods Enzymol; 2017; 584():157-183. PubMed ID: 28065262
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
    Moehlmann T; Winkler E; Xia X; Edbauer D; Murrell J; Capell A; Kaether C; Zheng H; Ghetti B; Haass C; Steiner H
    Proc Natl Acad Sci U S A; 2002 Jun; 99(12):8025-30. PubMed ID: 12048239
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The beta-secretase, BACE: a prime drug target for Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2001 Oct; 17(2):157-70. PubMed ID: 11816789
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
    Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
    J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia.
    Jung S; Nah J; Han J; Choi SG; Kim H; Park J; Pyo HK; Jung YK
    J Neurochem; 2016 Jun; 137(5):770-81. PubMed ID: 26924229
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.
    Cam M; Durieu E; Bodin M; Manousopoulou A; Koslowski S; Vasylieva N; Barnych B; Hammock BD; Bohl B; Koch P; Omori C; Yamamoto K; Hata S; Suzuki T; Karg F; Gizzi P; Erakovic Haber V; Bencetic Mihaljevic V; Tavcar B; Portelius E; Pannee J; Blennow K; Zetterberg H; Garbis SD; Auvray P; Gerber H; Fraering J; Fraering PC; Meijer L
    J Alzheimers Dis; 2018; 62(4):1663-1681. PubMed ID: 29504531
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels.
    Schedin-Weiss S; Inoue M; Hromadkova L; Teranishi Y; Yamamoto NG; Wiehager B; Bogdanovic N; Winblad B; Sandebring-Matton A; Frykman S; Tjernberg LO
    Alzheimers Res Ther; 2017 Aug; 9(1):57. PubMed ID: 28764767
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
    Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
    Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
    [TBL] [Abstract][Full Text] [Related]  

  • 20. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.