BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

255 related articles for article (PubMed ID: 31227365)

  • 21. Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies.
    Soni JP; Nikitha Reddy G; Rahman Z; Sharma A; Spandana A; Phanindranath R; Dandekar MP; Nagesh N; Shankaraiah N
    Bioorg Chem; 2023 Feb; 131():106313. PubMed ID: 36516521
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Discovery of novel triazolophthalazine derivatives as DNA intercalators and topoisomerase II inhibitors.
    Sakr H; Ayyad RR; El-Helby AA; Khalifa MM; Mahdy HA
    Arch Pharm (Weinheim); 2021 Jun; 354(6):e2000456. PubMed ID: 33554352
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and biological evaluation of arylcinnamide linked combretastatin-A4 hybrids as tubulin polymerization inhibitors and apoptosis inducing agents.
    Kamal A; Bajee S; Lakshma Nayak V; Venkata Subba Rao A; Nagaraju B; Ratna Reddy C; Jeevak Sopanrao K; Alarifi A
    Bioorg Med Chem Lett; 2016 Jun; 26(12):2957-2964. PubMed ID: 27161282
    [TBL] [Abstract][Full Text] [Related]  

  • 24. New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study.
    Nemr MTM; AboulMagd AM
    Bioorg Chem; 2020 Oct; 103():104134. PubMed ID: 32750610
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors.
    Yao BL; Mai YW; Chen SB; Xie HT; Yao PF; Ou TM; Tan JH; Wang HG; Li D; Huang SL; Gu LQ; Huang ZS
    Eur J Med Chem; 2015 Mar; 92():540-53. PubMed ID: 25599951
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors.
    Pedatella S; Cerchia C; Manfra M; Cioce A; Bolognese A; Lavecchia A
    Eur J Med Chem; 2020 Feb; 187():111960. PubMed ID: 31869654
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors.
    El-Helby AA; Sakr H; Ayyad RR; Mahdy HA; Khalifa MM; Belal A; Rashed M; El-Sharkawy A; Metwaly AM; Elhendawy MA; Radwan MM; ElSohly MA; Eissa IH
    Bioorg Chem; 2020 Oct; 103():104233. PubMed ID: 32882440
    [TBL] [Abstract][Full Text] [Related]  

  • 28. 5-Nitro-Thiophene-Thiosemicarbazone Derivatives Present Antitumor Activity Mediated by Apoptosis and DNA Intercalation.
    Roque Marques KM; do Desterro MR; de Arruda SM; de Araújo Neto LN; do Carmo Alves de Lima M; de Almeida SMV; da Silva ECD; de Aquino TM; da Silva-Júnior EF; de Araújo-Júnior JX; de M Silva M; de A Dantas MD; Santos JCC; Figueiredo IM; Bazin MA; Marchand P; da Silva TG; Mendonça Junior FJB
    Curr Top Med Chem; 2019; 19(13):1075-1091. PubMed ID: 31223089
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors.
    Zhou DC; Lu YT; Mai YW; Zhang C; Xia J; Yao PF; Wang HG; Huang SL; Huang ZS
    Bioorg Chem; 2019 Oct; 91():103131. PubMed ID: 31377387
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors.
    Zhang W; Zhang B; Zhang W; Yang T; Wang N; Gao C; Tan C; Liu H; Jiang Y
    Eur J Med Chem; 2016 Jun; 116():59-70. PubMed ID: 27060757
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Design, synthesis and biological evaluation of new β-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase I inhibitors.
    Kovvuri J; Nagaraju B; Nayak VL; Akunuri R; Rao MPN; Ajitha A; Nagesh N; Kamal A
    Eur J Med Chem; 2018 Jan; 143():1563-1577. PubMed ID: 29129513
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
    Thapa P; Kadayat TM; Park S; Shin S; Thapa Magar TB; Bist G; Shrestha A; Na Y; Kwon Y; Lee ES
    Bioorg Chem; 2016 Jun; 66():145-59. PubMed ID: 27174797
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity.
    Nunhart P; Konkoľová E; Janovec L; Jendželovský R; Vargová J; Ševc J; Matejová M; Miltáková B; Fedoročko P; Kozurkova M
    Bioorg Chem; 2020 Jan; 94():103393. PubMed ID: 31679839
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Synthesis and biological research of novel azaacridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors.
    Li D; Yuan Z; Chen S; Zhang C; Song L; Gao C; Chen Y; Tan C; Jiang Y
    Bioorg Med Chem; 2017 Jul; 25(13):3437-3446. PubMed ID: 28511910
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and
    Khalifa MM; Al-Karmalawy AA; Elkaeed EB; Nafie MS; Tantawy MA; Eissa IH; Mahdy HA
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):299-314. PubMed ID: 34894955
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers.
    Kamal A; Shaik B; Nayak VL; Nagaraju B; Kapure JS; Shaheer Malik M; Shaik TB; Prasad B
    Bioorg Med Chem; 2014 Oct; 22(19):5155-67. PubMed ID: 25192811
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison.
    Kunwar S; Hwang SY; Katila P; Park S; Jeon KH; Kim D; Kadayat TM; Kwon Y; Lee ES
    Eur J Med Chem; 2021 Dec; 226():113860. PubMed ID: 34597897
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases.
    Khadka DB; Tran GH; Shin S; Nguyen HT; Cao HT; Zhao C; Jin Y; Van HT; Chau MV; Kwon Y; Le TN; Cho WJ
    Eur J Med Chem; 2015 Oct; 103():69-79. PubMed ID: 26334499
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity.
    Nemr MTM; Sonousi A; Marzouk AA
    Bioorg Chem; 2020 Dec; 105():104446. PubMed ID: 33171405
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities.
    Chang SM; Christian W; Wu MH; Chen TL; Lin YW; Suen CS; Pidugu HB; Detroja D; Shah A; Hwang MJ; Su TL; Lee TC
    Eur J Med Chem; 2017 Feb; 127():235-249. PubMed ID: 28064078
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.