182 related articles for article (PubMed ID: 31235832)
1. Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B.
Demcsák A; Geisz A; Sahin-Tóth M
Sci Rep; 2019 Jun; 9(1):9188. PubMed ID: 31235832
[TBL] [Abstract][Full Text] [Related]
2. Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.
Wartmann T; Mayerle J; Kähne T; Sahin-Tóth M; Ruthenbürger M; Matthias R; Kruse A; Reinheckel T; Peters C; Weiss FU; Sendler M; Lippert H; Schulz HU; Aghdassi A; Dummer A; Teller S; Halangk W; Lerch MM
Gastroenterology; 2010 Feb; 138(2):726-37. PubMed ID: 19900452
[TBL] [Abstract][Full Text] [Related]
3. Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.
Sendler M; Weiss FU; Golchert J; Homuth G; van den Brandt C; Mahajan UM; Partecke LI; Döring P; Gukovsky I; Gukovskaya AS; Wagh PR; Lerch MM; Mayerle J
Gastroenterology; 2018 Feb; 154(3):704-718.e10. PubMed ID: 29079517
[TBL] [Abstract][Full Text] [Related]
4. Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.
Sendler M; Maertin S; John D; Persike M; Weiss FU; Krüger B; Wartmann T; Wagh P; Halangk W; Schaschke N; Mayerle J; Lerch MM
J Biol Chem; 2016 Jul; 291(28):14717-31. PubMed ID: 27226576
[TBL] [Abstract][Full Text] [Related]
5. Double deficiency of cathepsin B and L in the mouse pancreas alters trypsin activity without affecting acute pancreatitis severity.
Chen W; Imasaka M; Iwama H; Nishiura H; Ohmuraya M
Pancreatology; 2022 Nov; 22(7):880-886. PubMed ID: 36038449
[TBL] [Abstract][Full Text] [Related]
6. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
Halangk W; Lerch MM; Brandt-Nedelev B; Roth W; Ruthenbuerger M; Reinheckel T; Domschke W; Lippert H; Peters C; Deussing J
J Clin Invest; 2000 Sep; 106(6):773-81. PubMed ID: 10995788
[TBL] [Abstract][Full Text] [Related]
7. Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death.
Kereszturi E; Sahin-Tóth M
J Biol Chem; 2009 Nov; 284(48):33392-9. PubMed ID: 19801634
[TBL] [Abstract][Full Text] [Related]
8. Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.
Geisz A; Hegyi P; Sahin-Tóth M
FEBS J; 2013 Jun; 280(12):2888-99. PubMed ID: 23601753
[TBL] [Abstract][Full Text] [Related]
9. Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.
Szilágyi L; Kénesi E; Katona G; Kaslik G; Juhász G; Gráf L
J Biol Chem; 2001 Jul; 276(27):24574-80. PubMed ID: 11312265
[TBL] [Abstract][Full Text] [Related]
10. Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).
Teich N; Le Maréchal C; Kukor Z; Caca K; Witzigmann H; Chen JM; Tóth M; Mössner J; Keim V; Férec C; Sahin-Tóth M
Hum Mutat; 2004 Jan; 23(1):22-31. PubMed ID: 14695529
[TBL] [Abstract][Full Text] [Related]
11. Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
Aghdassi AA; John DS; Sendler M; Weiss FU; Reinheckel T; Mayerle J; Lerch MM
J Biol Chem; 2018 Jan; 293(3):1018-1029. PubMed ID: 29229780
[TBL] [Abstract][Full Text] [Related]
12. Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis.
Kukor Z; Mayerle J; Krüger B; Tóth M; Steed PM; Halangk W; Lerch MM; Sahin-Tóth M
J Biol Chem; 2002 Jun; 277(24):21389-96. PubMed ID: 11932257
[TBL] [Abstract][Full Text] [Related]
13. Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B.
Lindkvist B; Fajardo I; Pejler G; Borgström A
Pancreatology; 2006; 6(3):224-31. PubMed ID: 16534247
[TBL] [Abstract][Full Text] [Related]
14. The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition.
Nemoda Z; Sahin-Tóth M
J Biol Chem; 2005 Aug; 280(33):29645-52. PubMed ID: 15970597
[TBL] [Abstract][Full Text] [Related]
15. Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.
Németh BC; Wartmann T; Halangk W; Sahin-Tóth M
J Biol Chem; 2013 Aug; 288(33):24049-62. PubMed ID: 23814066
[TBL] [Abstract][Full Text] [Related]
16. Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen.
Simon P; Weiss FU; Sahin-Toth M; Parry M; Nayler O; Lenfers B; Schnekenburger J; Mayerle J; Domschke W; Lerch MM
J Biol Chem; 2002 Feb; 277(7):5404-10. PubMed ID: 11719509
[TBL] [Abstract][Full Text] [Related]
17. Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases.
Kukor Z; Tóth M; Sahin-Tóth M
Eur J Biochem; 2003 May; 270(9):2047-58. PubMed ID: 12709065
[TBL] [Abstract][Full Text] [Related]
18. Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules.
Zierke L; John D; Gischke M; Tran QT; Sendler M; Weiss FU; Bornscheuer UT; Ritter C; Lerch MM; Aghdassi AA
Cell Mol Life Sci; 2024 May; 81(1):207. PubMed ID: 38709385
[TBL] [Abstract][Full Text] [Related]
19. Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis.
Orekhova A; Németh BC; Jancsó Z; Geisz A; Mosztbacher D; Demcsák A; Sahin-Tóth M
Am J Physiol Gastrointest Liver Physiol; 2021 Dec; 321(6):G719-G734. PubMed ID: 34643096
[TBL] [Abstract][Full Text] [Related]
20. Intragenic duplication: a novel mutational mechanism in hereditary pancreatitis.
Joergensen MT; Geisz A; Brusgaard K; Schaffalitzky de Muckadell OB; Hegyi P; Gerdes AM; Sahin-Tóth M
Pancreas; 2011 May; 40(4):540-6. PubMed ID: 21499207
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]