219 related articles for article (PubMed ID: 31260448)
1. XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease.
Piróg KA; Dennis EP; Hartley CL; Jackson RM; Soul J; Schwartz JM; Bateman JF; Boot-Handford RP; Briggs MD
PLoS Genet; 2019 Jul; 15(7):e1008215. PubMed ID: 31260448
[TBL] [Abstract][Full Text] [Related]
2. An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia.
Nundlall S; Rajpar MH; Bell PA; Clowes C; Zeeff LA; Gardner B; Thornton DJ; Boot-Handford RP; Briggs MD
Cell Stress Chaperones; 2010 Nov; 15(6):835-49. PubMed ID: 20428984
[TBL] [Abstract][Full Text] [Related]
3. XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease.
Cameron TL; Bell KM; Gresshoff IL; Sampurno L; Mullan L; Ermann J; Glimcher LH; Boot-Handford RP; Bateman JF
PLoS Genet; 2015 Sep; 11(9):e1005505. PubMed ID: 26372225
[TBL] [Abstract][Full Text] [Related]
4. Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation.
Bell PA; Piróg KA; Fresquet M; Thornton DJ; Boot-Handford RP; Briggs MD
Arthritis Rheum; 2012 May; 64(5):1529-39. PubMed ID: 22083516
[TBL] [Abstract][Full Text] [Related]
5. Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases.
Hartley CL; Edwards S; Mullan L; Bell PA; Fresquet M; Boot-Handford RP; Briggs MD
Hum Mol Genet; 2013 Dec; 22(25):5262-75. PubMed ID: 23956175
[TBL] [Abstract][Full Text] [Related]
6. Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis.
Bell PA; Dennis EP; Hartley CL; Jackson RM; Porter A; Boot-Handford RP; Pirog KA; Briggs MD
Cell Stress Chaperones; 2019 Jan; 24(1):159-173. PubMed ID: 30543055
[TBL] [Abstract][Full Text] [Related]
7. Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias.
Pretemer Y; Kawai S; Nagata S; Nishio M; Watanabe M; Tamaki S; Alev C; Yamanaka Y; Xue JY; Wang Z; Fukiage K; Tsukanaka M; Futami T; Ikegawa S; Toguchida J
Stem Cell Reports; 2021 Mar; 16(3):610-625. PubMed ID: 33636111
[TBL] [Abstract][Full Text] [Related]
8. Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.
Cameron TL; Gresshoff IL; Bell KM; Piróg KA; Sampurno L; Hartley CL; Sanford EM; Wilson R; Ermann J; Boot-Handford RP; Glimcher LH; Briggs MD; Bateman JF
Osteoarthritis Cartilage; 2015 Apr; 23(4):661-70. PubMed ID: 25600960
[TBL] [Abstract][Full Text] [Related]
9. Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy.
Cameron TL; Bell KM; Tatarczuch L; Mackie EJ; Rajpar MH; McDermott BT; Boot-Handford RP; Bateman JF
PLoS One; 2011; 6(9):e24600. PubMed ID: 21935428
[TBL] [Abstract][Full Text] [Related]
10. Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth.
Kung LH; Rajpar MH; Preziosi R; Briggs MD; Boot-Handford RP
PLoS One; 2015; 10(2):e0117016. PubMed ID: 25693198
[TBL] [Abstract][Full Text] [Related]
11. Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.
Leighton MP; Nundlall S; Starborg T; Meadows RS; Suleman F; Knowles L; Wagener R; Thornton DJ; Kadler KE; Boot-Handford RP; Briggs MD
Hum Mol Genet; 2007 Jul; 16(14):1728-41. PubMed ID: 17517694
[TBL] [Abstract][Full Text] [Related]
12. Herpes Simplex Virus 1 UL41 Protein Suppresses the IRE1/XBP1 Signal Pathway of the Unfolded Protein Response via Its RNase Activity.
Zhang P; Su C; Jiang Z; Zheng C
J Virol; 2017 Feb; 91(4):. PubMed ID: 27928013
[TBL] [Abstract][Full Text] [Related]
13. Hypertrophic chondrocytes have a limited capacity to cope with increases in endoplasmic reticulum stress without triggering the unfolded protein response.
Kung LH; Rajpar MH; Briggs MD; Boot-Handford RP
J Histochem Cytochem; 2012 Oct; 60(10):734-48. PubMed ID: 22859705
[TBL] [Abstract][Full Text] [Related]
14. Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3.
Cotterill SL; Jackson GC; Leighton MP; Wagener R; Mäkitie O; Cole WG; Briggs MD
Hum Mutat; 2005 Dec; 26(6):557-65. PubMed ID: 16287128
[TBL] [Abstract][Full Text] [Related]
15. Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X.
Forouhan M; Mori K; Boot-Handford RP
Matrix Biol; 2018 Sep; 70():50-71. PubMed ID: 29522813
[TBL] [Abstract][Full Text] [Related]
16. Targeted induction of endoplasmic reticulum stress induces cartilage pathology.
Rajpar MH; McDermott B; Kung L; Eardley R; Knowles L; Heeran M; Thornton DJ; Wilson R; Bateman JF; Poulsom R; Arvan P; Kadler KE; Briggs MD; Boot-Handford RP
PLoS Genet; 2009 Oct; 5(10):e1000691. PubMed ID: 19834559
[TBL] [Abstract][Full Text] [Related]
17. COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid.
Ho MS; Tsang KY; Lo RL; Susic M; Mäkitie O; Chan TW; Ng VC; Sillence DO; Boot-Handford RP; Gibson G; Cheung KM; Cole WG; Cheah KS; Chan D
Hum Mol Genet; 2007 May; 16(10):1201-15. PubMed ID: 17403716
[TBL] [Abstract][Full Text] [Related]
18. Curcumin Reduces Pathological Endoplasmic Reticulum Stress through Increasing Proteolysis of Mutant Matrilin-3.
Dennis EP; Watson RN; McPate F; Briggs MD
Int J Mol Sci; 2023 Jan; 24(2):. PubMed ID: 36675026
[TBL] [Abstract][Full Text] [Related]
19. Identification and functional coordination analysis of gene co-expression networks in different tissues of XBP1 cartilage-specific deficient mice.
Li X; Pan Y; Liu K; Yang Y; Ye Y; Xu Q; Fan M; Guo F
Cell Signal; 2024 Jan; 113():110929. PubMed ID: 37875231
[TBL] [Abstract][Full Text] [Related]
20. Carbamazepine reduces disease severity in a mouse model of metaphyseal chondrodysplasia type Schmid caused by a premature stop codon (Y632X) in the Col10a1 gene.
Forouhan M; Sonntag S; Boot-Handford RP
Hum Mol Genet; 2018 Nov; 27(22):3840-3853. PubMed ID: 30010889
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
