These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

216 related articles for article (PubMed ID: 31263268)

  • 1. Phosphorylated Rho-GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras-GTP to regulate cell migration.
    Senoo H; Kamimura Y; Kimura R; Nakajima A; Sawai S; Sesaki H; Iijima M
    Nat Cell Biol; 2019 Jul; 21(7):867-878. PubMed ID: 31263268
    [TBL] [Abstract][Full Text] [Related]  

  • 2. KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis.
    Senoo H; Murata D; Wai M; Arai K; Iwata W; Sesaki H; Iijima M
    Mol Cell; 2021 Nov; 81(22):4622-4634.e8. PubMed ID: 34551282
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling.
    Senoo H; Wai M; Matsubayashi HT; Sesaki H; Iijima M
    Cell Rep; 2020 Nov; 33(8):108427. PubMed ID: 33238110
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen.
    Torti M; Manganaro D; Visconte C; Zarà M; Canino J; Vismara M; Canobbio I; Guidetti GF
    Platelets; 2020 May; 31(4):521-529. PubMed ID: 31509054
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.
    Morrison Joly M; Williams MM; Hicks DJ; Jones B; Sanchez V; Young CD; Sarbassov DD; Muller WJ; Brantley-Sieders D; Cook RS
    Breast Cancer Res; 2017 Jun; 19(1):74. PubMed ID: 28666462
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.
    Ueda T; Kikuchi A; Ohga N; Yamamoto J; Takai Y
    J Biol Chem; 1990 Jun; 265(16):9373-80. PubMed ID: 2111820
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways.
    Lim L; Manser E; Leung T; Hall C
    Eur J Biochem; 1996 Dec; 242(2):171-85. PubMed ID: 8973630
    [TBL] [Abstract][Full Text] [Related]  

  • 8. ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.
    Chen CH; Shaikenov T; Peterson TR; Aimbetov R; Bissenbaev AK; Lee SW; Wu J; Lin HK; Sarbassov dos D
    Sci Signal; 2011 Feb; 4(161):ra10. PubMed ID: 21343617
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alkaline intracellular pH (pHi) increases PI3K activity to promote mTORC1 and mTORC2 signaling and function during growth factor limitation.
    Kazyken D; Lentz SI; Wadley M; Fingar DC
    J Biol Chem; 2023 Sep; 299(9):105097. PubMed ID: 37507012
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt.
    Tooley AS; Kazyken D; Bodur C; Gonzalez IE; Fingar DC
    J Biol Chem; 2021 Aug; 297(2):100942. PubMed ID: 34245780
    [TBL] [Abstract][Full Text] [Related]  

  • 11. PI3K/Akt promotes feedforward mTORC2 activation through IKKα.
    Dan HC; Antonia RJ; Baldwin AS
    Oncotarget; 2016 Apr; 7(16):21064-75. PubMed ID: 27027448
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phosphatidylinositol 4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs.
    Zheng Y; Glaven JA; Wu WJ; Cerione RA
    J Biol Chem; 1996 Sep; 271(39):23815-9. PubMed ID: 8798610
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK; Pizzo SV
    PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
    [TBL] [Abstract][Full Text] [Related]  

  • 14. F-actin rearrangement is regulated by mTORC2/Akt/Girdin in mouse fertilized eggs.
    Wu D; Yu D; Wang X; Yu B
    Cell Prolif; 2016 Dec; 49(6):740-750. PubMed ID: 27666957
    [TBL] [Abstract][Full Text] [Related]  

  • 15. AMPK directly activates mTORC2 to promote cell survival during acute energetic stress.
    Kazyken D; Magnuson B; Bodur C; Acosta-Jaquez HA; Zhang D; Tong X; Barnes TM; Steinl GK; Patterson NE; Altheim CH; Sharma N; Inoki K; Cartee GD; Bridges D; Yin L; Riddle SM; Fingar DC
    Sci Signal; 2019 Jun; 12(585):. PubMed ID: 31186373
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration.
    Razmara M; Monazzam A; Skogseid B
    Cell Commun Signal; 2018 Oct; 16(1):64. PubMed ID: 30285764
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.
    Yamamoto T; Kaibuchi K; Mizuno T; Hiroyoshi M; Shirataki H; Takai Y
    J Biol Chem; 1990 Sep; 265(27):16626-34. PubMed ID: 2118909
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.
    Saci A; Cantley LC; Carpenter CL
    Mol Cell; 2011 Apr; 42(1):50-61. PubMed ID: 21474067
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ras, PI3K and mTORC2 - three's a crowd?
    Smith SF; Collins SE; Charest PG
    J Cell Sci; 2020 Oct; 133(19):. PubMed ID: 33033115
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.
    Chen CH; Kiyan V; Zhylkibayev AA; Kazyken D; Bulgakova O; Page KE; Bersimbaev RI; Spooner E; Sarbassov DD
    J Biol Chem; 2013 Sep; 288(38):27019-27030. PubMed ID: 23928304
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.