BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

231 related articles for article (PubMed ID: 31264961)

  • 1. Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation.
    Macpherson JA; Theisen A; Masino L; Fets L; Driscoll PC; Encheva V; Snijders AP; Martin SR; Kleinjung J; Barran PE; Fraternali F; Anastasiou D
    Elife; 2019 Jul; 8():. PubMed ID: 31264961
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2.
    Srivastava D; Razzaghi M; Henzl MT; Dey M
    Biochemistry; 2017 Dec; 56(50):6517-6520. PubMed ID: 29182273
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.
    Liu VM; Howell AJ; Hosios AM; Li Z; Israelsen WJ; Vander Heiden MG
    FEBS Lett; 2020 Feb; 594(4):646-664. PubMed ID: 31642061
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural insight into mechanisms for dynamic regulation of PKM2.
    Wang P; Sun C; Zhu T; Xu Y
    Protein Cell; 2015 Apr; 6(4):275-287. PubMed ID: 25645022
    [TBL] [Abstract][Full Text] [Related]  

  • 5. An engineered photoswitchable mammalian pyruvate kinase.
    Gehrig S; Macpherson JA; Driscoll PC; Symon A; Martin SR; MacRae JI; Kleinjung J; Fraternali F; Anastasiou D
    FEBS J; 2017 Sep; 284(18):2955-2980. PubMed ID: 28715126
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2.
    Nandi S; Dey M
    J Biol Chem; 2020 Apr; 295(16):5390-5403. PubMed ID: 32144209
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Glycolytic reprogramming in cancer cells: PKM2 dimer predominance induced by pulsatile PFK-1 activity.
    Shi X; You L; Luo RY
    Phys Biol; 2019 Sep; 16(6):066007. PubMed ID: 31469100
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.
    Lv L; Xu YP; Zhao D; Li FL; Wang W; Sasaki N; Jiang Y; Zhou X; Li TT; Guan KL; Lei QY; Xiong Y
    Mol Cell; 2013 Nov; 52(3):340-52. PubMed ID: 24120661
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.
    Chen TJ; Wang HJ; Liu JS; Cheng HH; Hsu SC; Wu MC; Lu CH; Wu YF; Wu JW; Liu YY; Kung HJ; Wang WC
    Commun Biol; 2019; 2():105. PubMed ID: 30911680
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
    Srivastava D; Nandi S; Dey M
    Biochemistry; 2019 Sep; 58(35):3669-3682. PubMed ID: 31386812
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural basis of PKM2 regulation.
    Yang W
    Protein Cell; 2015 Apr; 6(4):238-40. PubMed ID: 25773278
    [No Abstract]   [Full Text] [Related]  

  • 12. Synergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis.
    Yang J; Liu H; Liu X; Gu C; Luo R; Chen HF
    J Chem Inf Model; 2016 Jun; 56(6):1184-1192. PubMed ID: 27227511
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress.
    Masaki S; Hashimoto K; Kihara D; Tsuzuki C; Kataoka N; Suzuki K
    Biochem Biophys Res Commun; 2020 Jun; 526(4):973-977. PubMed ID: 32295714
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate.
    Gavriilidou AFM; Holding FP; Mayer D; Coyle JE; Veprintsev DB; Zenobi R
    Biochemistry; 2018 Mar; 57(11):1685-1689. PubMed ID: 29499117
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The role of PKM2 in cancer progression and its structural and biological basis.
    Wu B; Liang Z; Lan H; Teng X; Wang C
    J Physiol Biochem; 2024 May; 80(2):261-275. PubMed ID: 38329688
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PKM2 Modulation in Head and Neck Squamous Cell Carcinoma.
    Boschert V; Teusch J; Müller-Richter UDA; Brands RC; Hartmann S
    Int J Mol Sci; 2022 Jan; 23(2):. PubMed ID: 35054968
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
    Nandi S; Razzaghi M; Srivastava D; Dey M
    J Biol Chem; 2020 Dec; 295(51):17425-17440. PubMed ID: 33453989
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species.
    Yokoyama M; Tanuma N; Shibuya R; Shiroki T; Abue M; Yamamoto K; Miura K; Yamaguchi K; Sato I; Tamai K; Satoh K
    Int J Oncol; 2018 Mar; 52(3):881-891. PubMed ID: 29393401
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Moderate DNA damage promotes metabolic flux into PPP via PKM2 Y-105 phosphorylation: a feature that favours cancer cells.
    Kumar B; Bamezai RN
    Mol Biol Rep; 2015 Aug; 42(8):1317-21. PubMed ID: 25840825
    [TBL] [Abstract][Full Text] [Related]  

  • 20. EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
    Yang W; Xia Y; Cao Y; Zheng Y; Bu W; Zhang L; You MJ; Koh MY; Cote G; Aldape K; Li Y; Verma IM; Chiao PJ; Lu Z
    Mol Cell; 2012 Dec; 48(5):771-84. PubMed ID: 23123196
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.