These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 31282667)

  • 1. Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme.
    Bunzel HA; Kries H; Marchetti L; Zeymer C; Mittl PRE; Mulholland AJ; Hilvert D
    J Am Chem Soc; 2019 Jul; 141(30):11745-11748. PubMed ID: 31282667
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Precision is essential for efficient catalysis in an evolved Kemp eliminase.
    Blomberg R; Kries H; Pinkas DM; Mittl PR; Grütter MG; Privett HK; Mayo SL; Hilvert D
    Nature; 2013 Nov; 503(7476):418-21. PubMed ID: 24132235
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series.
    Khersonsky O; Röthlisberger D; Dym O; Albeck S; Jackson CJ; Baker D; Tawfik DS
    J Mol Biol; 2010 Mar; 396(4):1025-42. PubMed ID: 20036254
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes.
    Wolfenden R
    J Biol Chem; 2014 Oct; 289(44):30198-30204. PubMed ID: 25210030
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The role of reorganization energy in rational enzyme design.
    Fuxreiter M; Mones L
    Curr Opin Chem Biol; 2014 Aug; 21():34-41. PubMed ID: 24769299
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Protein engineering from "scratch" is maturing.
    Höhne M; Bornscheuer UT
    Angew Chem Int Ed Engl; 2014 Jan; 53(5):1200-2. PubMed ID: 24339163
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Towards Rational Computational Engineering of Psychrophilic Enzymes.
    Sočan J; Isaksen GV; Brandsdal BO; Åqvist J
    Sci Rep; 2019 Dec; 9(1):19147. PubMed ID: 31844096
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Engineered enzymes for improved organic synthesis.
    Hult K; Berglund P
    Curr Opin Biotechnol; 2003 Aug; 14(4):395-400. PubMed ID: 12943848
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evolution of dynamical networks enhances catalysis in a designer enzyme.
    Bunzel HA; Anderson JLR; Hilvert D; Arcus VL; van der Kamp MW; Mulholland AJ
    Nat Chem; 2021 Oct; 13(10):1017-1022. PubMed ID: 34413499
    [TBL] [Abstract][Full Text] [Related]  

  • 10. How directed evolution reshapes the energy landscape in an enzyme to boost catalysis.
    Otten R; Pádua RAP; Bunzel HA; Nguyen V; Pitsawong W; Patterson M; Sui S; Perry SL; Cohen AE; Hilvert D; Kern D
    Science; 2020 Dec; 370(6523):1442-1446. PubMed ID: 33214289
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Computational Design of Synthetic Enzymes.
    Vaissier Welborn V; Head-Gordon T
    Chem Rev; 2019 Jun; 119(11):6613-6630. PubMed ID: 30277066
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymes.
    Herschlag D; Natarajan A
    Biochemistry; 2013 Mar; 52(12):2050-67. PubMed ID: 23488725
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Establishment of mesophilic-like catalytic properties in a thermophilic enzyme without affecting its thermal stability.
    Akanuma S; Bessho M; Kimura H; Furukawa R; Yokobori SI; Yamagishi A
    Sci Rep; 2019 Jun; 9(1):9346. PubMed ID: 31249343
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kemp elimination catalysts by computational enzyme design.
    Röthlisberger D; Khersonsky O; Wollacott AM; Jiang L; DeChancie J; Betker J; Gallaher JL; Althoff EA; Zanghellini A; Dym O; Albeck S; Houk KN; Tawfik DS; Baker D
    Nature; 2008 May; 453(7192):190-5. PubMed ID: 18354394
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Stabilizing biocatalysts.
    Bommarius AS; Paye MF
    Chem Soc Rev; 2013 Aug; 42(15):6534-65. PubMed ID: 23807146
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A roadmap to directed enzyme evolution and screening systems for biotechnological applications.
    Martínez R; Schwaneberg U
    Biol Res; 2013; 46(4):395-405. PubMed ID: 24510142
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Introduction to the thematic minireview series on enzyme evolution.
    Banerjee R
    J Biol Chem; 2014 Oct; 289(44):30196-30197. PubMed ID: 25210045
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular dynamics explorations of active site structure in designed and evolved enzymes.
    Osuna S; Jiménez-Osés G; Noey EL; Houk KN
    Acc Chem Res; 2015 Apr; 48(4):1080-9. PubMed ID: 25738880
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A new intrinsic thermal parameter for enzymes reveals true temperature optima.
    Peterson ME; Eisenthal R; Danson MJ; Spence A; Daniel RM
    J Biol Chem; 2004 May; 279(20):20717-22. PubMed ID: 14973131
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Hybrid schemes based on quantum mechanics/molecular mechanics simulations goals to success, problems, and perspectives.
    Ferrer S; Ruiz-Pernía J; Martí S; Moliner V; Tuñón I; Bertrán J; Andrés J
    Adv Protein Chem Struct Biol; 2011; 85():81-142. PubMed ID: 21920322
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.