363 related articles for article (PubMed ID: 31283229)
1. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.
Lu MC; Zhang X; Wu F; Tan SJ; Zhao J; You QD; Jiang ZY
J Med Chem; 2019 Jul; 62(14):6796-6813. PubMed ID: 31283229
[TBL] [Abstract][Full Text] [Related]
2. Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.
Lu MC; Shao HL; Liu T; You QD; Jiang ZY
Eur J Med Chem; 2020 Dec; 207():112734. PubMed ID: 32866756
[TBL] [Abstract][Full Text] [Related]
3. A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury.
Li G; Liu H; Feng R; Kang TS; Wang W; Ko CN; Wong CY; Ye M; Ma DL; Wan JB; Leung CH
Redox Biol; 2021 Dec; 48():102129. PubMed ID: 34526248
[TBL] [Abstract][Full Text] [Related]
4. Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Lu Q; Tan S; Gu W; Li F; Hua W; Zhang S; Chen F; Tang L
J Ethnopharmacol; 2019 Oct; 243():112089. PubMed ID: 31310828
[TBL] [Abstract][Full Text] [Related]
5. Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway.
Luo DD; Chen JF; Liu JJ; Xie JH; Zhang ZB; Gu JY; Zhuo JY; Huang S; Su ZR; Sun ZH
Food Chem Toxicol; 2019 Jan; 123():349-362. PubMed ID: 30423402
[TBL] [Abstract][Full Text] [Related]
6. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
Davies TG; Wixted WE; Coyle JE; Griffiths-Jones C; Hearn K; McMenamin R; Norton D; Rich SJ; Richardson C; Saxty G; Willems HM; Woolford AJ; Cottom JE; Kou JP; Yonchuk JG; Feldser HG; Sanchez Y; Foley JP; Bolognese BJ; Logan G; Podolin PL; Yan H; Callahan JF; Heightman TD; Kerns JK
J Med Chem; 2016 Apr; 59(8):3991-4006. PubMed ID: 27031670
[TBL] [Abstract][Full Text] [Related]
7. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Bresciani A; Missineo A; Gallo M; Cerretani M; Fezzardi P; Tomei L; Cicero DO; Altamura S; Santoprete A; Ingenito R; Bianchi E; Pacifici R; Dominguez C; Munoz-Sanjuan I; Harper S; Toledo-Sherman L; Park LC
Arch Biochem Biophys; 2017 Oct; 631():31-41. PubMed ID: 28801166
[TBL] [Abstract][Full Text] [Related]
8. Carbon monoxide releasing molecule A-1 attenuates acetaminophen-mediated hepatotoxicity and improves survival of mice by induction of Nrf2 and related genes.
Upadhyay KK; Jadeja RN; Thadani JM; Joshi A; Vohra A; Mevada V; Patel R; Khurana S; Devkar RV
Toxicol Appl Pharmacol; 2018 Dec; 360():99-108. PubMed ID: 30273691
[TBL] [Abstract][Full Text] [Related]
9. Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense
Zhao L; Zhang X; Chen Z; Lai Y; Xu J; Zhou R; Ma P; Cai W; Zeng Y; Wu X; Ying H; Yu F
Food Funct; 2024 May; 15(9):4954-4969. PubMed ID: 38602356
[TBL] [Abstract][Full Text] [Related]
10. Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
Zhou HS; Hu LB; Zhang H; Shan WX; Wang Y; Li X; Liu T; Zhao J; You QD; Jiang ZY
J Med Chem; 2020 Oct; 63(19):11149-11168. PubMed ID: 32902980
[TBL] [Abstract][Full Text] [Related]
11. Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC.
Shi L; Hao Z; Zhang S; Wei M; Lu B; Wang Z; Ji L
Biochem Pharmacol; 2018 Apr; 150():9-23. PubMed ID: 29338970
[TBL] [Abstract][Full Text] [Related]
12. Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface.
Bhakkiyalakshmi E; Dineshkumar K; Karthik S; Sireesh D; Hopper W; Paulmurugan R; Ramkumar KM
Bioorg Med Chem; 2016 Aug; 24(16):3378-86. PubMed ID: 27312421
[TBL] [Abstract][Full Text] [Related]
13. Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
Zhang L; Xu L; Chen H; Zhang W; Xing C; Qu Z; Yu J; Zhuang C
Eur J Med Chem; 2021 Oct; 222():113599. PubMed ID: 34119834
[TBL] [Abstract][Full Text] [Related]
14. Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.
Shen Z; Wang Y; Su Z; Kou R; Xie K; Song F
Chem Biol Interact; 2018 Feb; 282():22-28. PubMed ID: 29331651
[TBL] [Abstract][Full Text] [Related]
15. Discovery of Keap1-Nrf2 small-molecule inhibitors from phytochemicals based on molecular docking.
Li M; Huang W; Jie F; Wang M; Zhong Y; Chen Q; Lu B
Food Chem Toxicol; 2019 Nov; 133():110758. PubMed ID: 31412289
[TBL] [Abstract][Full Text] [Related]
16. Hepatoprotective Effect of Polysaccharides Isolated from
Lin G; Luo D; Liu J; Wu X; Chen J; Huang Q; Su L; Zeng L; Wang H; Su Z
Oxid Med Cell Longev; 2018; 2018():6962439. PubMed ID: 30116489
[TBL] [Abstract][Full Text] [Related]
17. c-Jun NH
Chen Y; Liu K; Zhang J; Hai Y; Wang P; Wang H; Liu Q; Wong CCL; Yao J; Gao Y; Liao Y; Tang X; Wang XJ
Hepatology; 2020 May; 71(5):1787-1801. PubMed ID: 31945188
[TBL] [Abstract][Full Text] [Related]
18. Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
Wei M; Zheng Z; Shi L; Jin Y; Ji L
Toxicol Sci; 2018 Mar; 162(1):99-112. PubMed ID: 29136249
[TBL] [Abstract][Full Text] [Related]
19. Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
Heightman TD; Callahan JF; Chiarparin E; Coyle JE; Griffiths-Jones C; Lakdawala AS; McMenamin R; Mortenson PN; Norton D; Peakman TM; Rich SJ; Richardson C; Rumsey WL; Sanchez Y; Saxty G; Willems HMG; Wolfe L; Woolford AJ; Wu Z; Yan H; Kerns JK; Davies TG
J Med Chem; 2019 May; 62(9):4683-4702. PubMed ID: 30973731
[TBL] [Abstract][Full Text] [Related]
20. Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response.
Feng RB; Wang Y; He C; Yang Y; Wan JB
Food Chem Toxicol; 2018 Sep; 119():479-488. PubMed ID: 29066411
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
