188 related articles for article (PubMed ID: 31288073)
1. Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells.
Penman SL; Sharma P; Aerts H; Park BK; Weaver RJ; Chadwick AE
Toxicol In Vitro; 2019 Dec; 61():104595. PubMed ID: 31288073
[TBL] [Abstract][Full Text] [Related]
2. Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.
Sharanek A; Burban A; Humbert L; Bachour-El Azzi P; Felix-Gomes N; Rainteau D; Guillouzo A
Toxicol Sci; 2015 Oct; 147(2):573-87. PubMed ID: 26198044
[TBL] [Abstract][Full Text] [Related]
3. Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.
Qiu X; Zhang Y; Liu T; Shen H; Xiao Y; Bourner MJ; Pratt JR; Thompson DC; Marathe P; Humphreys WG; Lai Y
Mol Pharm; 2016 Apr; 13(4):1206-16. PubMed ID: 26910619
[TBL] [Abstract][Full Text] [Related]
4. Establishment of a Drug-Induced, Bile Acid-Dependent Hepatotoxicity Model Using HepaRG Cells.
Susukida T; Sekine S; Nozaki M; Tokizono M; Oizumi K; Horie T; Ito K
J Pharm Sci; 2016 Apr; 105(4):1550-60. PubMed ID: 26952880
[TBL] [Abstract][Full Text] [Related]
5. Establishment of an in vitro cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids.
Koga T; Takeuchi K; Umehara K
J Toxicol Sci; 2023; 48(1):47-56. PubMed ID: 36599427
[TBL] [Abstract][Full Text] [Related]
6. Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes.
Woolbright BL; McGill MR; Yan H; Jaeschke H
Basic Clin Pharmacol Toxicol; 2016 Feb; 118(2):160-7. PubMed ID: 26176423
[TBL] [Abstract][Full Text] [Related]
7. The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity.
Kamalian L; Douglas O; Jolly CE; Snoeys J; Simic D; Monshouwer M; Williams DP; Kevin Park B; Chadwick AE
Toxicol In Vitro; 2018 Dec; 53():136-147. PubMed ID: 30096366
[TBL] [Abstract][Full Text] [Related]
8. Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.
Anthérieu S; Bachour-El Azzi P; Dumont J; Abdel-Razzak Z; Guguen-Guillouzo C; Fromenty B; Robin MA; Guillouzo A
Hepatology; 2013 Apr; 57(4):1518-29. PubMed ID: 23175273
[TBL] [Abstract][Full Text] [Related]
9. The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly CE; Douglas O; Kamalian L; Jenkins RE; Beckett AJ; Penman SL; Williams DP; Monshouwer M; Simic D; Snoeys J; Park BK; Chadwick AE
Toxicol Appl Pharmacol; 2020 Sep; 403():115163. PubMed ID: 32730777
[TBL] [Abstract][Full Text] [Related]
10. Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes.
Susukida T; Sekine S; Ogimura E; Aoki S; Oizumi K; Horie T; Ito K
Toxicol In Vitro; 2015 Oct; 29(7):1454-63. PubMed ID: 26055650
[TBL] [Abstract][Full Text] [Related]
11. Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?
Ferreira M; Coxito PM; Sardão VA; Palmeira CM; Oliveira PJ
Cardiovasc Toxicol; 2005; 5(1):63-73. PubMed ID: 15738586
[TBL] [Abstract][Full Text] [Related]
12. Characterizing the mechanism of thiazolidinedione-induced hepatotoxicity: An in vitro model in mitochondria.
Hu D; Wu CQ; Li ZJ; Liu Y; Fan X; Wang QJ; Ding RG
Toxicol Appl Pharmacol; 2015 Apr; 284(2):134-41. PubMed ID: 25727309
[TBL] [Abstract][Full Text] [Related]
13. Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential.
Burban A; Sharanek A; Humbert L; Eguether T; Guguen-Guillouzo C; Rainteau D; Guillouzo A
Toxicol Sci; 2019 Apr; 168(2):474-485. PubMed ID: 30629237
[TBL] [Abstract][Full Text] [Related]
14. Mitochondrially-mediated toxicity of bile acids.
Palmeira CM; Rolo AP
Toxicology; 2004 Oct; 203(1-3):1-15. PubMed ID: 15363577
[TBL] [Abstract][Full Text] [Related]
15. Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis.
Muchova L; Vanova K; Suk J; Micuda S; Dolezelova E; Fuksa L; Cerny D; Farghali H; Zelenkova M; Lenicek M; Wong RJ; Vreman HJ; Vitek L
J Cell Mol Med; 2015 May; 19(5):924-33. PubMed ID: 25683492
[TBL] [Abstract][Full Text] [Related]
16. Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells.
van der Mark VA; Adam AAA; Chang JC; Oude Elferink RP; Chamuleau RAFM; Hoekstra R
Toxicol Appl Pharmacol; 2020 Jul; 399():115055. PubMed ID: 32428594
[TBL] [Abstract][Full Text] [Related]
17. Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.
Rodrigues AD; Lai Y; Cvijic ME; Elkin LL; Zvyaga T; Soars MG
Drug Metab Dispos; 2014 Apr; 42(4):566-74. PubMed ID: 24115749
[TBL] [Abstract][Full Text] [Related]
18. Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.
Bachour-El Azzi P; Sharanek A; Burban A; Li R; Guével RL; Abdel-Razzak Z; Stieger B; Guguen-Guillouzo C; Guillouzo A
Toxicol Sci; 2015 May; 145(1):157-68. PubMed ID: 25690737
[TBL] [Abstract][Full Text] [Related]
19. Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.
Burbank MG; Burban A; Sharanek A; Weaver RJ; Guguen-Guillouzo C; Guillouzo A
Drug Metab Dispos; 2016 Nov; 44(11):1780-1793. PubMed ID: 27538918
[TBL] [Abstract][Full Text] [Related]
20. HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity.
van Wenum M; Treskes P; Adam AAA; van der Mark VA; Jongejan A; Moerland PD; van Gulik TM; Oude Elferink RPJ; Chamuleau RAFM; Hoekstra R
Cell Physiol Biochem; 2018; 48(5):2189-2204. PubMed ID: 30110678
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
