These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43. Koyama A; Sugai A; Kato T; Ishihara T; Shiga A; Toyoshima Y; Koyama M; Konno T; Hirokawa S; Yokoseki A; Nishizawa M; Kakita A; Takahashi H; Onodera O Nucleic Acids Res; 2016 Jul; 44(12):5820-36. PubMed ID: 27257061 [TBL] [Abstract][Full Text] [Related]
3. Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones. Highley JR; Kirby J; Jansweijer JA; Webb PS; Hewamadduma CA; Heath PR; Higginbottom A; Raman R; Ferraiuolo L; Cooper-Knock J; McDermott CJ; Wharton SB; Shaw PJ; Ince PG Neuropathol Appl Neurobiol; 2014 Oct; 40(6):670-85. PubMed ID: 24750229 [TBL] [Abstract][Full Text] [Related]
4. Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis. D'Alton S; Altshuler M; Lewis J RNA; 2015 Aug; 21(8):1419-32. PubMed ID: 26089325 [TBL] [Abstract][Full Text] [Related]
5. A robust TDP-43 knock-in mouse model of ALS. Huang SL; Wu LS; Lee M; Chang CW; Cheng WC; Fang YS; Chen YR; Cheng PL; Shen CJ Acta Neuropathol Commun; 2020 Jan; 8(1):3. PubMed ID: 31964415 [TBL] [Abstract][Full Text] [Related]
6. Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. Fratta P; Sivakumar P; Humphrey J; Lo K; Ricketts T; Oliveira H; Brito-Armas JM; Kalmar B; Ule A; Yu Y; Birsa N; Bodo C; Collins T; Conicella AE; Mejia Maza A; Marrero-Gagliardi A; Stewart M; Mianne J; Corrochano S; Emmett W; Codner G; Groves M; Fukumura R; Gondo Y; Lythgoe M; Pauws E; Peskett E; Stanier P; Teboul L; Hallegger M; Calvo A; Chiò A; Isaacs AM; Fawzi NL; Wang E; Housman DE; Baralle F; Greensmith L; Buratti E; Plagnol V; Fisher EM; Acevedo-Arozena A EMBO J; 2018 Jun; 37(11):. PubMed ID: 29764981 [TBL] [Abstract][Full Text] [Related]
8. TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis. Deshaies JE; Shkreta L; Moszczynski AJ; Sidibé H; Semmler S; Fouillen A; Bennett ER; Bekenstein U; Destroismaisons L; Toutant J; Delmotte Q; Volkening K; Stabile S; Aulas A; Khalfallah Y; Soreq H; Nanci A; Strong MJ; Chabot B; Vande Velde C Brain; 2018 May; 141(5):1320-1333. PubMed ID: 29562314 [TBL] [Abstract][Full Text] [Related]
9. Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice. Wu LS; Cheng WC; Shen CK J Biol Chem; 2012 Aug; 287(33):27335-44. PubMed ID: 22718760 [TBL] [Abstract][Full Text] [Related]
10. Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis. Ishihara T; Ariizumi Y; Shiga A; Kato T; Tan CF; Sato T; Miki Y; Yokoo M; Fujino T; Koyama A; Yokoseki A; Nishizawa M; Kakita A; Takahashi H; Onodera O Hum Mol Genet; 2013 Oct; 22(20):4136-47. PubMed ID: 23740936 [TBL] [Abstract][Full Text] [Related]
11. TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition. Torres P; Rico-Rios S; Ceron-Codorniu M; Santacreu-Vilaseca M; Seoane-Miraz D; Jad Y; Ayala V; Mariño G; Beltran M; Miralles MP; Andrés-Benito P; Fernandez-Irigoyen J; Santamaria E; López-Otín C; Soler RM; Povedano M; Ferrer I; Pamplona R; Wood MJA; Varela MA; Portero-Otin M Acta Neuropathol; 2024 Sep; 148(1):45. PubMed ID: 39305312 [TBL] [Abstract][Full Text] [Related]
12. Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis. Smethurst P; Risse E; Tyzack GE; Mitchell JS; Taha DM; Chen YR; Newcombe J; Collinge J; Sidle K; Patani R Brain; 2020 Feb; 143(2):430-440. PubMed ID: 32040555 [TBL] [Abstract][Full Text] [Related]
13. An integrative miRNA-mRNA expression analysis identifies miRNA signatures associated with SOD1 and TARDBP patient-derived motor neurons. Dash BP; Freischmidt A; Weishaupt JH; Hermann A Hum Mol Genet; 2024 Jul; 33(15):1300-1314. PubMed ID: 38676626 [TBL] [Abstract][Full Text] [Related]
14. Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS). Volkening K; Leystra-Lantz C; Yang W; Jaffee H; Strong MJ Brain Res; 2009 Dec; 1305():168-82. PubMed ID: 19815002 [TBL] [Abstract][Full Text] [Related]
15. Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS. Ebstein SY; Yagudayeva I; Shneider NA Cell Rep; 2019 Jan; 26(2):364-373.e4. PubMed ID: 30625319 [TBL] [Abstract][Full Text] [Related]
16. Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo. Kabashi E; Lin L; Tradewell ML; Dion PA; Bercier V; Bourgouin P; Rochefort D; Bel Hadj S; Durham HD; Vande Velde C; Rouleau GA; Drapeau P Hum Mol Genet; 2010 Feb; 19(4):671-83. PubMed ID: 19959528 [TBL] [Abstract][Full Text] [Related]
17. Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models. Marques RF; Engler JB; Küchler K; Jones RA; Lingner T; Salinas G; Gillingwater TH; Friese MA; Duncan KE Hum Mol Genet; 2020 Sep; 29(16):2647-2661. PubMed ID: 32686835 [TBL] [Abstract][Full Text] [Related]
18. Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex. Koike Y; Sugai A; Hara N; Ito J; Yokoseki A; Ishihara T; Yamagishi T; Tsuboguchi S; Tada M; Ikeuchi T; Kakita A; Onodera O Commun Biol; 2021 Sep; 4(1):1107. PubMed ID: 34548609 [TBL] [Abstract][Full Text] [Related]
19. HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations. Fazal R; Boeynaems S; Swijsen A; De Decker M; Fumagalli L; Moisse M; Vanneste J; Guo W; Boon R; Vercruysse T; Eggermont K; Swinnen B; Beckers J; Pakravan D; Vandoorne T; Vanden Berghe P; Verfaillie C; Van Den Bosch L; Van Damme P EMBO J; 2021 Apr; 40(7):e106177. PubMed ID: 33694180 [TBL] [Abstract][Full Text] [Related]
20. Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. Coyne AN; Lorenzini I; Chou CC; Torvund M; Rogers RS; Starr A; Zaepfel BL; Levy J; Johannesmeyer J; Schwartz JC; Nishimune H; Zinsmaier K; Rossoll W; Sattler R; Zarnescu DC Cell Rep; 2017 Oct; 21(1):110-125. PubMed ID: 28978466 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]