BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 31318464)

  • 1. Phenylalanine meta-Hydroxylase: A Single Residue Mediates Mechanistic Control of Aromatic Amino Acid Hydroxylation.
    Grüschow S; Sadler JC; Sharratt PJ; Goss RJM
    Chembiochem; 2020 Feb; 21(3):417-422. PubMed ID: 31318464
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.
    Zhang W; Ames BD; Walsh CT
    Biochemistry; 2011 Jun; 50(24):5401-3. PubMed ID: 21615132
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Insights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylation.
    Pavon JA; Fitzpatrick PF
    Biochemistry; 2006 Sep; 45(36):11030-7. PubMed ID: 16953590
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The aromatic amino acid hydroxylases.
    Fitzpatrick PF
    Adv Enzymol Relat Areas Mol Biol; 2000; 74():235-94. PubMed ID: 10800597
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanism of aromatic amino acid hydroxylation.
    Fitzpatrick PF
    Biochemistry; 2003 Dec; 42(48):14083-91. PubMed ID: 14640675
    [No Abstract]   [Full Text] [Related]  

  • 6. Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase.
    Daubner SC; Avila A; Bailey JO; Barrera D; Bermudez JY; Giles DH; Khan CA; Shaheen N; Thompson JW; Vasquez J; Oxley SP; Fitzpatrick PF
    Biochemistry; 2013 Feb; 52(8):1446-55. PubMed ID: 23368961
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Kinetic isotope effects on aromatic and benzylic hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase as probes of chemical mechanism and reactivity.
    Panay AJ; Fitzpatrick PF
    Biochemistry; 2008 Oct; 47(42):11118-24. PubMed ID: 18817418
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum.
    Kino K; Hara R; Nozawa A
    J Biosci Bioeng; 2009 Sep; 108(3):184-9. PubMed ID: 19664549
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural insights into the regulation of aromatic amino acid hydroxylation.
    Fitzpatrick PF
    Curr Opin Struct Biol; 2015 Dec; 35():1-6. PubMed ID: 26241318
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Directed Metabolic Pathway Evolution Enables Functional Pterin-Dependent Aromatic-Amino-Acid Hydroxylation in
    Luo H; Yang L; Kim SH; Wulff T; Feist AM; Herrgard M; Palsson BØ
    ACS Synth Biol; 2020 Mar; 9(3):494-499. PubMed ID: 32149495
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Measurement of the intramolecular isotope effect on aliphatic hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase.
    Panay AJ; Fitzpatrick PF
    J Am Chem Soc; 2010 Apr; 132(16):5584-5. PubMed ID: 20355730
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Reversing the substrate specificities of phenylalanine and tyrosine hydroxylase: aspartate 425 of tyrosine hydroxylase is essential for L-DOPA formation.
    Daubner SC; Melendez J; Fitzpatrick PF
    Biochemistry; 2000 Aug; 39(32):9652-61. PubMed ID: 10933781
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase.
    Carr RT; Balasubramanian S; Hawkins PC; Benkovic SJ
    Biochemistry; 1995 Jun; 34(22):7525-32. PubMed ID: 7779797
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Intrinsic isotope effects on benzylic hydroxylation by the aromatic amino acid hydroxylases: evidence for hydrogen tunneling, coupled motion, and similar reactivities.
    Pavon JA; Fitzpatrick PF
    J Am Chem Soc; 2005 Nov; 127(47):16414-5. PubMed ID: 16305226
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase.
    Fitzpatrick PF
    Arch Biochem Biophys; 2023 Feb; 735():109518. PubMed ID: 36639008
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of the second coordination sphere residue tyrosine 179 in substrate affinity and catalytic activity of phenylalanine hydroxylase.
    Zoidakis J; Sam M; Volner A; Han A; Vu K; Abu-Omar MM
    J Biol Inorg Chem; 2004 Apr; 9(3):289-96. PubMed ID: 14999516
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 7-Tetrahydrobiopterin is an uncoupled cofactor for rat hepatic phenylalanine hydroxylase.
    Davis MD; Kaufman S
    FEBS Lett; 1991 Jul; 285(1):17-20. PubMed ID: 2065777
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of chimeric pterin-dependent hydroxylases: contributions of the regulatory domains of tyrosine and phenylalanine hydroxylase to substrate specificity.
    Daubner SC; Hillas PJ; Fitzpatrick PF
    Biochemistry; 1997 Sep; 36(39):11574-82. PubMed ID: 9305947
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron.
    Kinzie SD; Thevis M; Ngo K; Whitelegge J; Loo JA; Abu-Omar MM
    J Am Chem Soc; 2003 Apr; 125(16):4710-1. PubMed ID: 12696880
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanism of aromatic hydroxylation by an activated FeIV=O core in tetrahydrobiopterin-dependent hydroxylases.
    Bassan A; Blomberg MR; Siegbahn PE
    Chemistry; 2003 Sep; 9(17):4055-67. PubMed ID: 12953191
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.