171 related articles for article (PubMed ID: 31329594)
1. Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes.
Salas-Sarduy E; Landaburu LU; Carmona AK; Cazzulo JJ; Agüero F; Alvarez VE; Niemirowicz GT
PLoS Negl Trop Dis; 2019 Jul; 13(7):e0007560. PubMed ID: 31329594
[TBL] [Abstract][Full Text] [Related]
2. Characterization of the M32 metallocarboxypeptidase of Trypanosoma brucei: differences and similarities with its orthologue in Trypanosoma cruzi.
Frasch AP; Carmona AK; Juliano L; Cazzulo JJ; Niemirowicz GT
Mol Biochem Parasitol; 2012 Aug; 184(2):63-70. PubMed ID: 22575602
[TBL] [Abstract][Full Text] [Related]
3. Substrate specificity profiling of M32 metallocarboxypeptidases from Trypanosoma cruzi and Trypanosoma brucei.
Frasch AP; Bouvier LA; Oppenheimer FM; Juliano MA; Juliano L; Carmona AK; Cazzulo JJ; Niemirowicz GT
Mol Biochem Parasitol; 2018 Jan; 219():10-16. PubMed ID: 29246805
[TBL] [Abstract][Full Text] [Related]
4. Two metallocarboxypeptidases from the protozoan Trypanosoma cruzi belong to the M32 family, found so far only in prokaryotes.
Niemirowicz G; Parussini F; Agüero F; Cazzulo JJ
Biochem J; 2007 Jan; 401(2):399-410. PubMed ID: 17007610
[TBL] [Abstract][Full Text] [Related]
5. Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes.
Salas-Sarduy E; Landaburu LU; Karpiak J; Madauss KP; Cazzulo JJ; Agüero F; Alvarez VE
Sci Rep; 2017 Sep; 7(1):12073. PubMed ID: 28935948
[TBL] [Abstract][Full Text] [Related]
6. Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity.
Pérez B; Bouvier LA; Cazzulo JJ; Agüero F; Salas-Sarduy E; Alvarez VE
Antimicrob Agents Chemother; 2021 Feb; 65(3):. PubMed ID: 33318019
[TBL] [Abstract][Full Text] [Related]
7. Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits.
Blaazer AR; Orrling KM; Shanmugham A; Jansen C; Maes L; Edink E; Sterk GJ; Siderius M; England P; Bailey D; de Esch IJ; Leurs R
J Biomol Screen; 2015 Jan; 20(1):131-40. PubMed ID: 25231971
[TBL] [Abstract][Full Text] [Related]
8. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
Mott BT; Ferreira RS; Simeonov A; Jadhav A; Ang KK; Leister W; Shen M; Silveira JT; Doyle PS; Arkin MR; McKerrow JH; Inglese J; Austin CP; Thomas CJ; Shoichet BK; Maloney DJ
J Med Chem; 2010 Jan; 53(1):52-60. PubMed ID: 19908842
[TBL] [Abstract][Full Text] [Related]
9. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.
Pedró-Rosa L; Buckner FS; Ranade RM; Eberhart C; Madoux F; Gillespie JR; Koh CY; Brown S; Lohse J; Verlinde CL; Fan E; Bannister T; Scampavia L; Hol WG; Spicer T; Hodder P
J Biomol Screen; 2015 Jan; 20(1):122-30. PubMed ID: 25163684
[TBL] [Abstract][Full Text] [Related]
10. Targeting cysteine proteases in trypanosomatid disease drug discovery.
Ferreira LG; Andricopulo AD
Pharmacol Ther; 2017 Dec; 180():49-61. PubMed ID: 28579388
[TBL] [Abstract][Full Text] [Related]
11. Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.
Volkov OA; Cosner CC; Brockway AJ; Kramer M; Booker M; Zhong S; Ketcherside A; Wei S; Longgood J; McCoy M; Richardson TE; Wring SA; Peel M; Klinger JD; Posner BA; De Brabander JK; Phillips MA
ACS Infect Dis; 2017 Jul; 3(7):512-526. PubMed ID: 28350440
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
Yang PY; Wang M; Li L; Wu H; He CY; Yao SQ
Chemistry; 2012 May; 18(21):6528-41. PubMed ID: 22488888
[TBL] [Abstract][Full Text] [Related]
13. Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei.
Faria J; Moraes CB; Song R; Pascoalino BS; Lee N; Siqueira-Neto JL; Cruz DJ; Parkinson T; Ioset JR; Cordeiro-da-Silva A; Freitas-Junior LH
J Biomol Screen; 2015 Jan; 20(1):70-81. PubMed ID: 25342146
[TBL] [Abstract][Full Text] [Related]
14. Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.
Benítez D; Medeiros A; Fiestas L; Panozzo-Zenere EA; Maiwald F; Prousis KC; Roussaki M; Calogeropoulou T; Detsi A; Jaeger T; Šarlauskas J; Peterlin Mašič L; Kunick C; Labadie GR; Flohé L; Comini MA
PLoS Negl Trop Dis; 2016 Apr; 10(4):e0004617. PubMed ID: 27070550
[TBL] [Abstract][Full Text] [Related]
15. Metacaspases, autophagins and metallocarboxypeptidases: potential new targets for chemotherapy of the trypanosomiases.
Alvarez VE; Niemirowicz GT; Cazzulo JJ
Curr Med Chem; 2013; 20(25):3069-77. PubMed ID: 23514417
[TBL] [Abstract][Full Text] [Related]
16. High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.
Annang F; Pérez-Moreno G; García-Hernández R; Cordon-Obras C; Martín J; Tormo JR; Rodríguez L; de Pedro N; Gómez-Pérez V; Valente M; Reyes F; Genilloud O; Vicente F; Castanys S; Ruiz-Pérez LM; Navarro M; Gamarro F; González-Pacanowska D
J Biomol Screen; 2015 Jan; 20(1):82-91. PubMed ID: 25332350
[TBL] [Abstract][Full Text] [Related]
17. Cruzain inhibitors: efforts made, current leads and a structural outlook of new hits.
Martinez-Mayorga K; Byler KG; Ramirez-Hernandez AI; Terrazas-Alvares DE
Drug Discov Today; 2015 Jul; 20(7):890-8. PubMed ID: 25697479
[TBL] [Abstract][Full Text] [Related]
18. Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase.
Smith P; Ho CK; Takagi Y; Djaballah H; Shuman S
mBio; 2016 Feb; 7(1):e00058-16. PubMed ID: 26908574
[TBL] [Abstract][Full Text] [Related]
19. A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.
Sharlow ER; Lyda TA; Dodson HC; Mustata G; Morris MT; Leimgruber SS; Lee KH; Kashiwada Y; Close D; Lazo JS; Morris JC
PLoS Negl Trop Dis; 2010 Apr; 4(4):e659. PubMed ID: 20405000
[TBL] [Abstract][Full Text] [Related]
20. Approaches to protozoan drug discovery: phenotypic screening.
Sykes ML; Avery VM
J Med Chem; 2013 Oct; 56(20):7727-40. PubMed ID: 23927763
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
