241 related articles for article (PubMed ID: 31337748)
21. MicroRNA-199a-5p Induced Autophagy and Inhibits the Pathogenesis of Ankylosing Spondylitis by Modulating the mTOR Signaling via Directly Targeting Ras Homolog Enriched in Brain (Rheb).
Wang Y; Luo J; Wang X; Yang B; Cui L
Cell Physiol Biochem; 2017; 42(6):2481-2491. PubMed ID: 28848090
[TBL] [Abstract][Full Text] [Related]
22. Focal cortical dysplasia II caused by brain somatic mutation of IRS-1 is associated with ERK signaling pathway activation.
Li X; Wang T; Liu N; Cai A; Zhang J; Zhang F; Liu Q; Wang J; Wu Y; Gao K; Jiang YW
Cereb Cortex; 2024 Jun; 34(6):. PubMed ID: 38836287
[TBL] [Abstract][Full Text] [Related]
23. FCD Type II and mTOR pathway: Evidence for different mechanisms involved in the pathogenesis of dysmorphic neurons.
Rossini L; Villani F; Granata T; Tassi L; Tringali G; Cardinale F; Aronica E; Spreafico R; Garbelli R
Epilepsy Res; 2017 Jan; 129():146-156. PubMed ID: 28056425
[TBL] [Abstract][Full Text] [Related]
24. Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?
Thom M; Liu J; Bongaarts A; Reinten RJ; Paradiso B; Jäger HR; Reeves C; Somani A; An S; Marsdon D; McEvoy A; Miserocchi A; Thorne L; Newman F; Bucur S; Honavar M; Jacques T; Aronica E
Brain Pathol; 2018 Mar; 28(2):155-171. PubMed ID: 28833756
[TBL] [Abstract][Full Text] [Related]
25. Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain.
Ma X; Du W; Wang W; Luo L; Huang M; Wang H; Lin R; Li Z; Shi H; Yuan T; Jiang W; Worley PF; Xu T
Cell Death Dis; 2020 Sep; 11(9):747. PubMed ID: 32920594
[TBL] [Abstract][Full Text] [Related]
26. Detection of somatic and germline pathogenic variants in adult cohort of drug-resistant focal epilepsies.
Ferri L; Menghi V; Licchetta L; Dimartino P; Minardi R; Davì C; Di Vito L; Cifaldi E; Zenesini C; Gozzo F; Pelliccia V; Mariani V; de Spelorzi YCC; Gustincich S; Seri M; Tassi L; Pippucci T; Bisulli F
Epilepsy Behav; 2024 Apr; 153():109716. PubMed ID: 38508103
[TBL] [Abstract][Full Text] [Related]
27. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Tee AR; Manning BD; Roux PP; Cantley LC; Blenis J
Curr Biol; 2003 Aug; 13(15):1259-68. PubMed ID: 12906785
[TBL] [Abstract][Full Text] [Related]
28. Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb.
Nakashima M; Saitsu H; Takei N; Tohyama J; Kato M; Kitaura H; Shiina M; Shirozu H; Masuda H; Watanabe K; Ohba C; Tsurusaki Y; Miyake N; Zheng Y; Sato T; Takebayashi H; Ogata K; Kameyama S; Kakita A; Matsumoto N
Ann Neurol; 2015 Sep; 78(3):375-86. PubMed ID: 26018084
[TBL] [Abstract][Full Text] [Related]
29. Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
Mazhab-Jafari MT; Marshall CB; Ho J; Ishiyama N; Stambolic V; Ikura M
J Biol Chem; 2014 May; 289(18):12195-201. PubMed ID: 24648513
[TBL] [Abstract][Full Text] [Related]
30. Anti-seizure gene therapy for focal cortical dysplasia.
Almacellas Barbanoj A; Graham RT; Maffei B; Carpenter JC; Leite M; Hoke J; Hardjo F; Scott-Solache J; Chimonides C; Schorge S; Kullmann DM; Magloire V; Lignani G
Brain; 2024 Feb; 147(2):542-553. PubMed ID: 38100333
[TBL] [Abstract][Full Text] [Related]
31. Identification of genetic characteristics in pediatric epilepsy with focal cortical dysplasia type 2 using deep whole-exome sequencing.
Xu Y; Zhao R; Wang M; Wang XH; Wang Y; Li H; Ma YY; Wu BB; Zhou YF
Mol Genet Genomic Med; 2022 Dec; 10(12):e2086. PubMed ID: 36342087
[TBL] [Abstract][Full Text] [Related]
32. Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice.
Hsieh LS; Wen JH; Nguyen LH; Zhang L; Getz SA; Torres-Reveron J; Wang Y; Spencer DD; Bordey A
Sci Transl Med; 2020 Nov; 12(570):. PubMed ID: 33208499
[TBL] [Abstract][Full Text] [Related]
33. Rheb, an activator of target of rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal muscle.
MacLea KS; Abuhagr AM; Pitts NL; Covi JA; Bader BD; Chang ES; Mykles DL
J Exp Biol; 2012 Feb; 215(Pt 4):590-604. PubMed ID: 22279066
[TBL] [Abstract][Full Text] [Related]
34. Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy.
Ribierre T; Bacq A; Donneger F; Doladilhe M; Maletic M; Roussel D; Le Roux I; Chassoux F; Devaux B; Adle-Biassette H; Ferrand-Sorbets S; Dorfmüller G; Chipaux M; Baldassari S; Poncer JC; Baulac S
Nat Neurosci; 2024 Jun; 27(6):1125-1136. PubMed ID: 38710875
[TBL] [Abstract][Full Text] [Related]
35. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
Karbowniczek M; Cash T; Cheung M; Robertson GP; Astrinidis A; Henske EP
J Biol Chem; 2004 Jul; 279(29):29930-7. PubMed ID: 15150271
[TBL] [Abstract][Full Text] [Related]
36. NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold.
Iffland PH; Everett ME; Cobb-Pitstick KM; Bowser LE; Barnes AE; Babus JK; Romanowski AJ; Baybis M; Elziny S; Puffenberger EG; Gonzaga-Jauregui C; Poulopoulos A; Carson VJ; Crino PB
Brain; 2022 Nov; 145(11):3872-3885. PubMed ID: 35136953
[TBL] [Abstract][Full Text] [Related]
37. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
[TBL] [Abstract][Full Text] [Related]
38. Balloon cells promote immune system activation in focal cortical dysplasia type 2b.
Zimmer TS; Broekaart DWM; Luinenburg M; Mijnsbergen C; Anink JJ; Sim NS; Michailidou I; Jansen FE; van Rijen PC; Lee JH; François L; van Eyll J; Dedeurwaerdere S; van Vliet EA; Mühlebner A; Mills JD; Aronica E
Neuropathol Appl Neurobiol; 2021 Oct; 47(6):826-839. PubMed ID: 34003514
[TBL] [Abstract][Full Text] [Related]
39. Somatic mutations involving TSC 1 and TSC2 genes in two children with focal cortical dysplasia.
Jha R; Kurup A; Kovilapu UB; Ranjan R; Sondhi V
Brain Dev; 2022 Feb; 44(2):166-172. PubMed ID: 34756499
[TBL] [Abstract][Full Text] [Related]
40. Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway.
Xing G; Luo Z; Zhong C; Pan X; Xu X
Med Sci Monit; 2016 Dec; 22():5141-5153. PubMed ID: 28025572
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]