344 related articles for article (PubMed ID: 31337749)
1. Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.
Hollingsworth SA; Kelly B; Valant C; Michaelis JA; Mastromihalis O; Thompson G; Venkatakrishnan AJ; Hertig S; Scammells PJ; Sexton PM; Felder CC; Christopoulos A; Dror RO
Nat Commun; 2019 Jul; 10(1):3289. PubMed ID: 31337749
[TBL] [Abstract][Full Text] [Related]
2. Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.
Miao Y; Goldfeld DA; Moo EV; Sexton PM; Christopoulos A; McCammon JA; Valant C
Proc Natl Acad Sci U S A; 2016 Sep; 113(38):E5675-84. PubMed ID: 27601651
[TBL] [Abstract][Full Text] [Related]
3. Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.
Abdul-Ridha A; López L; Keov P; Thal DM; Mistry SN; Sexton PM; Lane JR; Canals M; Christopoulos A
J Biol Chem; 2014 Feb; 289(9):6067-79. PubMed ID: 24443568
[TBL] [Abstract][Full Text] [Related]
4. Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.
Yeatman HR; Lane JR; Choy KH; Lambert NA; Sexton PM; Christopoulos A; Canals M
J Biol Chem; 2014 May; 289(22):15856-66. PubMed ID: 24753247
[TBL] [Abstract][Full Text] [Related]
5. Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.
Abdul-Ridha A; Lane JR; Mistry SN; López L; Sexton PM; Scammells PJ; Christopoulos A; Canals M
J Biol Chem; 2014 Nov; 289(48):33701-11. PubMed ID: 25326383
[TBL] [Abstract][Full Text] [Related]
6. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Thal DM; Sun B; Feng D; Nawaratne V; Leach K; Felder CC; Bures MG; Evans DA; Weis WI; Bachhawat P; Kobilka TS; Sexton PM; Kobilka BK; Christopoulos A
Nature; 2016 Mar; 531(7594):335-40. PubMed ID: 26958838
[TBL] [Abstract][Full Text] [Related]
7. Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions.
Lu S; Zhang J
J Med Chem; 2019 Jan; 62(1):24-45. PubMed ID: 29457894
[TBL] [Abstract][Full Text] [Related]
8. Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy.
Wakeham MCL; Davie BJ; Chalmers DK; Christopoulos A; Capuano B; Valant C; Scammells PJ
ACS Chem Neurosci; 2022 Jan; 13(1):97-111. PubMed ID: 34905693
[TBL] [Abstract][Full Text] [Related]
9. Identification of a Novel Allosteric Site at the M
Burger WAC; Gentry PR; Berizzi AE; Vuckovic Z; van der Westhuizen ET; Thompson G; Yeasmin M; Lindsley CW; Sexton PM; Langmead CJ; Tobin AB; Christopoulos A; Valant C; Thal DM
ACS Chem Neurosci; 2021 Aug; 12(16):3112-3123. PubMed ID: 34351123
[TBL] [Abstract][Full Text] [Related]
10. Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Kruse AC; Hu J; Pan AC; Arlow DH; Rosenbaum DM; Rosemond E; Green HF; Liu T; Chae PS; Dror RO; Shaw DE; Weis WI; Wess J; Kobilka BK
Nature; 2012 Feb; 482(7386):552-6. PubMed ID: 22358844
[TBL] [Abstract][Full Text] [Related]
11. Application of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein-Coupled Receptors.
Chan WKB; Carlson HA; Traynor JR
Mol Pharmacol; 2023 May; 103(5):274-285. PubMed ID: 36868791
[TBL] [Abstract][Full Text] [Related]
12. Structure-Activity Relationships of Pan-Gα
Berizzi AE; Bender AM; Lindsley CW; Conn PJ; Sexton PM; Langmead CJ; Christopoulos A
ACS Chem Neurosci; 2018 Jul; 9(7):1818-1828. PubMed ID: 29683647
[TBL] [Abstract][Full Text] [Related]
13. Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.
Dror RO; Green HF; Valant C; Borhani DW; Valcourt JR; Pan AC; Arlow DH; Canals M; Lane JR; Rahmani R; Baell JB; Sexton PM; Christopoulos A; Shaw DE
Nature; 2013 Nov; 503(7475):295-9. PubMed ID: 24121438
[TBL] [Abstract][Full Text] [Related]
14. Structure-based discovery of selective positive allosteric modulators of antagonists for the M
Korczynska M; Clark MJ; Valant C; Xu J; Moo EV; Albold S; Weiss DR; Torosyan H; Huang W; Kruse AC; Lyda BR; May LT; Baltos JA; Sexton PM; Kobilka BK; Christopoulos A; Shoichet BK; Sunahara RK
Proc Natl Acad Sci U S A; 2018 Mar; 115(10):E2419-E2428. PubMed ID: 29453275
[TBL] [Abstract][Full Text] [Related]
15. 6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M
Jörg M; van der Westhuizen ET; Khajehali E; Burger WAC; White JM; Choy KHC; Tobin AB; Sexton PM; Valant C; Capuano B; Christopoulos A; Scammells PJ
ACS Chem Neurosci; 2019 Mar; 10(3):1099-1114. PubMed ID: 30547573
[TBL] [Abstract][Full Text] [Related]
16. Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand-binding affinity and signal transduction.
Xu J; Tan P; Li H; Cui Y; Qiu Y; Wang H; Zhang X; Li J; Zhu L; Zhou W; Chen H
FASEB J; 2019 Mar; 33(3):3237-3251. PubMed ID: 30407877
[TBL] [Abstract][Full Text] [Related]
17. Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
Mohr K; Schmitz J; Schrage R; Tränkle C; Holzgrabe U
Angew Chem Int Ed Engl; 2013 Jan; 52(2):508-16. PubMed ID: 23225228
[TBL] [Abstract][Full Text] [Related]
18. A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.
Valant C; Gregory KJ; Hall NE; Scammells PJ; Lew MJ; Sexton PM; Christopoulos A
J Biol Chem; 2008 Oct; 283(43):29312-21. PubMed ID: 18723515
[TBL] [Abstract][Full Text] [Related]
19. Allosteric modulators targeting CNS muscarinic receptors.
Bock A; Schrage R; Mohr K
Neuropharmacology; 2018 Jul; 136(Pt C):427-437. PubMed ID: 28935216
[TBL] [Abstract][Full Text] [Related]
20. M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?
Scarpa M; Hesse S; Bradley SJ
Adv Pharmacol; 2020; 88():277-310. PubMed ID: 32416870
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
