BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

193 related articles for article (PubMed ID: 31341008)

  • 1. Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies.
    Scull CE; Zhang Y; Tower N; Rasmussen L; Padmalayam I; Hunter R; Zhai L; Bostwick R; Schneider DA
    Biochem J; 2019 Aug; 476(15):2209-2219. PubMed ID: 31341008
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Small Molecule RBI2 Disrupts Ribosome Biogenesis through Pre-rRNA Depletion.
    Scull CE; Twa G; Zhang Y; Yang NJ; Hunter RN; Augelli-Szafran CE; Schneider DA
    Cancers (Basel); 2023 Jun; 15(13):. PubMed ID: 37444413
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.
    Drygin D; Lin A; Bliesath J; Ho CB; O'Brien SE; Proffitt C; Omori M; Haddach M; Schwaebe MK; Siddiqui-Jain A; Streiner N; Quin JE; Sanij E; Bywater MJ; Hannan RD; Ryckman D; Anderes K; Rice WG
    Cancer Res; 2011 Feb; 71(4):1418-30. PubMed ID: 21159662
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
    Kusnadi EP; Trigos AS; Cullinane C; Goode DL; Larsson O; Devlin JR; Chan KT; De Souza DP; McConville MJ; McArthur GA; Thomas G; Sanij E; Poortinga G; Hannan RD; Hannan KM; Kang J; Pearson RB
    EMBO J; 2020 Nov; 39(21):e105111. PubMed ID: 32945574
    [TBL] [Abstract][Full Text] [Related]  

  • 5. rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.
    Negi SS; Brown P
    Oncotarget; 2015 Jul; 6(20):18094-104. PubMed ID: 26061708
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics.
    Catez F; Dalla Venezia N; Marcel V; Zorbas C; Lafontaine DLJ; Diaz JJ
    Biochem Pharmacol; 2019 Jan; 159():74-81. PubMed ID: 30468711
    [TBL] [Abstract][Full Text] [Related]  

  • 7. AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.
    Chan JC; Hannan KM; Riddell K; Ng PY; Peck A; Lee RS; Hung S; Astle MV; Bywater M; Wall M; Poortinga G; Jastrzebski K; Sheppard KE; Hemmings BA; Hall MN; Johnstone RW; McArthur GA; Hannan RD; Pearson RB
    Sci Signal; 2011 Aug; 4(188):ra56. PubMed ID: 21878679
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy.
    Lawrence MG; Obinata D; Sandhu S; Selth LA; Wong SQ; Porter LH; Lister N; Pook D; Pezaro CJ; Goode DL; Rebello RJ; Clark AK; Papargiris M; Van Gramberg J; Hanson AR; Banks P; Wang H; Niranjan B; Keerthikumar S; Hedwards S; Huglo A; Yang R; Henzler C; Li Y; Lopez-Campos F; Castro E; Toivanen R; Azad A; Bolton D; Goad J; Grummet J; Harewood L; Kourambas J; Lawrentschuk N; Moon D; Murphy DG; Sengupta S; Snow R; Thorne H; Mitchell C; Pedersen J; Clouston D; Norden S; Ryan A; Dehm SM; Tilley WD; Pearson RB; Hannan RD; Frydenberg M; Furic L; Taylor RA; Risbridger GP
    Eur Urol; 2018 Nov; 74(5):562-572. PubMed ID: 30049486
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate.
    Scala F; Brighenti E; Govoni M; Imbrogno E; Fornari F; Treré D; Montanaro L; Derenzini M
    Oncogene; 2016 Feb; 35(8):977-89. PubMed ID: 25961931
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance.
    El Hassouni B; Sarkisjan D; Vos JC; Giovannetti E; Peters GJ
    Curr Med Chem; 2019; 26(33):6020-6032. PubMed ID: 30501594
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?
    Brighenti E; Treré D; Derenzini M
    Oncotarget; 2015 Nov; 6(36):38617-27. PubMed ID: 26415219
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro.
    Stec MJ; Kelly NA; Many GM; Windham ST; Tuggle SC; Bamman MM
    Am J Physiol Endocrinol Metab; 2016 Apr; 310(8):E652-E661. PubMed ID: 26860985
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer.
    Bursać S; Prodan Y; Pullen N; Bartek J; Volarević S
    Trends Cancer; 2021 Jan; 7(1):57-76. PubMed ID: 32948502
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.
    Rebello RJ; Kusnadi E; Cameron DP; Pearson HB; Lesmana A; Devlin JR; Drygin D; Clark AK; Porter L; Pedersen J; Sandhu S; Risbridger GP; Pearson RB; Hannan RD; Furic L
    Clin Cancer Res; 2016 Nov; 22(22):5539-5552. PubMed ID: 27486174
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 9-Aminoacridine Inhibits Ribosome Biogenesis by Targeting Both Transcription and Processing of Ribosomal RNA.
    Anikin L; Pestov DG
    Int J Mol Sci; 2022 Jan; 23(3):. PubMed ID: 35163183
    [TBL] [Abstract][Full Text] [Related]  

  • 16. p53 induces a survival transcriptional response after nucleolar stress.
    Liao H; Gaur A; Mauvais C; Denicourt C
    Mol Biol Cell; 2021 Oct; 32(20):ar3. PubMed ID: 34319761
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A dynamic ribosomal biogenesis response is not required for IGF-1-mediated hypertrophy of human primary myotubes.
    Crossland H; Timmons JA; Atherton PJ
    FASEB J; 2017 Dec; 31(12):5196-5207. PubMed ID: 28774889
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells.
    Okamoto S; Miyano K; Kajikawa M; Yamauchi A; Kuribayashi F
    Biosci Biotechnol Biochem; 2020 Nov; 84(11):2319-2326. PubMed ID: 32799625
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ribosome Biogenesis: A Central Player in Cancer Metastasis and Therapeutic Resistance.
    Elhamamsy AR; Metge BJ; Alsheikh HA; Shevde LA; Samant RS
    Cancer Res; 2022 Jul; 82(13):2344-2353. PubMed ID: 35303060
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells.
    Turi Z; Senkyrikova M; Mistrik M; Bartek J; Moudry P
    Cell Cycle; 2018; 17(1):92-101. PubMed ID: 29143558
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.