BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 31353319)

  • 1. Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.
    Ehrnhoefer DE; Skotte NH; Reinshagen J; Qiu X; Windshügel B; Jaishankar P; Ladha S; Petina O; Khankischpur M; Nguyen YTN; Caron NS; Razeto A; Meyer Zu Rheda M; Deng Y; Huynh KT; Wittig I; Gribbon P; Renslo AR; Geffken D; Gul S; Hayden MR
    Cell Chem Biol; 2019 Sep; 26(9):1295-1305.e6. PubMed ID: 31353319
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.
    Graham RK; Deng Y; Carroll J; Vaid K; Cowan C; Pouladi MA; Metzler M; Bissada N; Wang L; Faull RL; Gray M; Yang XW; Raymond LA; Hayden MR
    J Neurosci; 2010 Nov; 30(45):15019-29. PubMed ID: 21068307
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.
    Graham RK; Deng Y; Pouladi MA; Vaid K; Ehrnhoefer D; Southwell AL; Bissada N; Franciosi S; Hayden MR
    J Huntingtons Dis; 2012; 1(2):243-60. PubMed ID: 25063333
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.
    Warby SC; Doty CN; Graham RK; Shively J; Singaraja RR; Hayden MR
    Mol Cell Neurosci; 2009 Feb; 40(2):121-7. PubMed ID: 18992820
    [TBL] [Abstract][Full Text] [Related]  

  • 5. p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
    Ehrnhoefer DE; Skotte NH; Ladha S; Nguyen YT; Qiu X; Deng Y; Huynh KT; Engemann S; Nielsen SM; Becanovic K; Leavitt BR; Hasholt L; Hayden MR
    Hum Mol Genet; 2014 Feb; 23(3):717-29. PubMed ID: 24070868
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
    Warby SC; Doty CN; Graham RK; Carroll JB; Yang YZ; Singaraja RR; Overall CM; Hayden MR
    Hum Mol Genet; 2008 Aug; 17(15):2390-404. PubMed ID: 18445618
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.
    Fox JH; Connor T; Stiles M; Kama J; Lu Z; Dorsey K; Lieberman G; Sapp E; Cherny RA; Banks M; Volitakis I; DiFiglia M; Berezovska O; Bush AI; Hersch SM
    J Biol Chem; 2011 May; 286(20):18320-30. PubMed ID: 21454633
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.
    Ehrnhoefer DE; Martin DDO; Schmidt ME; Qiu X; Ladha S; Caron NS; Skotte NH; Nguyen YTN; Vaid K; Southwell AL; Engemann S; Franciosi S; Hayden MR
    Acta Neuropathol Commun; 2018 Mar; 6(1):16. PubMed ID: 29510748
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
    Graham RK; Deng Y; Slow EJ; Haigh B; Bissada N; Lu G; Pearson J; Shehadeh J; Bertram L; Murphy Z; Warby SC; Doty CN; Roy S; Wellington CL; Leavitt BR; Raymond LA; Nicholson DW; Hayden MR
    Cell; 2006 Jun; 125(6):1179-91. PubMed ID: 16777606
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
    Riechers SP; Butland S; Deng Y; Skotte N; Ehrnhoefer DE; Russ J; Laine J; Laroche M; Pouladi MA; Wanker EE; Hayden MR; Graham RK
    Hum Mol Genet; 2016 Apr; 25(8):1600-18. PubMed ID: 26908611
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
    Hermel E; Gafni J; Propp SS; Leavitt BR; Wellington CL; Young JE; Hackam AS; Logvinova AV; Peel AL; Chen SF; Hook V; Singaraja R; Krajewski S; Goldsmith PC; Ellerby HM; Hayden MR; Bredesen DE; Ellerby LM
    Cell Death Differ; 2004 Apr; 11(4):424-38. PubMed ID: 14713958
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Compromised IGF signaling causes caspase-6 activation in Huntington disease.
    Skotte NH; Pouladi MA; Ehrnhoefer DE; Huynh K; Qiu X; Nielsen SMB; Nielsen TT; Nørremølle A; Hayden MR
    Exp Neurol; 2020 Oct; 332():113396. PubMed ID: 32622701
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.
    Landles C; Sathasivam K; Weiss A; Woodman B; Moffitt H; Finkbeiner S; Sun B; Gafni J; Ellerby LM; Trottier Y; Richards WG; Osmand A; Paganetti P; Bates GP
    J Biol Chem; 2010 Mar; 285(12):8808-23. PubMed ID: 20086007
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease.
    Bartl S; Xie Y; Potluri N; Kesineni R; Hencak K; Cengio LD; Balazs K; Oueslati A; Parth M; Salhat N; Siddu A; Smrzka O; Cicchetti F; Straffler G; Hayden MR; Southwell AL
    Neurobiol Dis; 2024 Jan; 190():106376. PubMed ID: 38092268
    [TBL] [Abstract][Full Text] [Related]  

  • 15. HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease.
    Fu Y; Sun X; Lu B
    Autophagy; 2018; 14(1):169-170. PubMed ID: 29130397
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
    Wellington CL; Ellerby LM; Gutekunst CA; Rogers D; Warby S; Graham RK; Loubser O; van Raamsdonk J; Singaraja R; Yang YZ; Gafni J; Bredesen D; Hersch SM; Leavitt BR; Roy S; Nicholson DW; Hayden MR
    J Neurosci; 2002 Sep; 22(18):7862-72. PubMed ID: 12223539
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific.
    Jansen AH; van Hal M; Op den Kelder IC; Meier RT; de Ruiter AA; Schut MH; Smith DL; Grit C; Brouwer N; Kamphuis W; Boddeke HW; den Dunnen WF; van Roon WM; Bates GP; Hol EM; Reits EA
    Glia; 2017 Jan; 65(1):50-61. PubMed ID: 27615381
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.
    Aharony I; Ehrnhoefer DE; Shruster A; Qiu X; Franciosi S; Hayden MR; Offen D
    Hum Mol Genet; 2015 May; 24(9):2604-14. PubMed ID: 25616965
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance.
    Martin DDO; Schmidt ME; Nguyen YT; Lazic N; Hayden MR
    FASEB J; 2019 Mar; 33(3):3190-3197. PubMed ID: 30423259
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.
    Schulze-Krebs A; Canneva F; Stemick J; Plank AC; Harrer J; Bates GP; Aeschlimann D; Steffan JS; von Hörsten S
    Int J Mol Sci; 2021 Aug; 22(16):. PubMed ID: 34445621
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.